12 research outputs found
COâ gasification of bio-char derived from conventional and microwave pyrolysis
Thermal-chemical processing of biomass is expected to provide renewable and clean energy and fuels in the future. Due to the nature of endothermic reactions, microwave and conventional heating have been applied to this technology. However, more studies need to be carried out to clarify the difference between these two heating technologies. In this work, we investigated two bio-char samples produced from conventional pyrolysis of wood biomass (yield of bio-char: 38.48 and 59.70 wt.%, respectively) and one bio-char produced from microwave pyrolysis with a yield of 45.16 wt.% from the same biomass sample at different process conditions. Various methodologies have been used to characterise the bio-chars. COâ gasification of bio-char has also been studied using a thermogravimetric analyser (TGA) and a fixed-bed reaction system. The results show that volatile and carbon contents of the bio-char derived from microwave pyrolysis were between the two conventional bio-chars. However, the microwave bio-char is more reactive for COâ gasification, as more CO was released during TGA experiments, and the CO release peak was narrower compared with the COâ gasification of the conventional bio-chars. It is suggested that the conventional bio-char is less reactive due to the presence of more secondary chars which are produced from secondary reactions of volatiles during the conventional biomass pyrolysis. While the microwave pyrolysis generates more uniform bio-chars with less secondary char, and therefore, has advantages of producing bio-char for downstream char gasification
The expression of Gli3, regulated by HOXD13, may play a role in idiopathic congenital talipes equinovarus
<p>Abstract</p> <p>Background</p> <p>Idiopathic congenital talipes equinovarus (ICTEV) is a congenital limb deformity. Based on extended transmission disequilibrium testing, <it>Gli-Kruppel family member 3 </it>(<it>Gli3</it>) has been identified as a candidate gene for ICTEV. Here, we verify the role of <it>Gli3 </it>in ICTEV development.</p> <p>Methods</p> <p>Using the rat ICTEV model, we analyzed the differences in <it>Gli3 </it>expression levels between model rats and normal control rats. We used luciferase reporter gene assays and ChIP/EMSA assays to analyze the regulatory elements of <it>Gli3</it>.</p> <p>Results</p> <p><it>Gli3 </it>showed higher expression levels in ICTEV model rats compared to controls (P < 0.05). We identified repressor and activator regions in the rat <it>Gli3 </it>promoter. The <it>Gli3 </it>promoter also contains two putative Hoxd13 binding sites. Using EMSA, the Hoxd13 binding site 2 was found to directly interact with Hoxd13 <it>in vitro</it>. ChIP assays of the Hoxd13-<it>Gli3 </it>promoter complex from a developing limb confirmed that endogenous Hoxd13 interacts with this region <it>in vivo</it>.</p> <p>Conclusion</p> <p>Our findings suggest that <it>HoxD13 </it>directly interacts with the promoter of <it>Gli3</it>. The increase of <it>Gli3 </it>expression in ICTEV model animal might result from the low expression of <it>HoxD13</it>.</p
Research on the Complexity and Chaos Control about a Closed-Loop Supply Chain with Dual-Channel Recycling and Uncertain Consumer Perception
Research on the Complexity and Chaos Control about a Closed-Loop Supply Chain with Dual-Channel Recycling and Uncertain Consumer Perception
According to game theory, chaotic dynamics theory, and complexity based on the literature review about the pricing strategy and recycling channels of the closed-loop supply chain, on the background of the widespread hybrid recycling channels in Chinese electronic products market, this paper builds a closed-loop supply chain model with dual-channel recycling composed of one manufacturer and one third-party. We assume that the consumer perception towards the remanufacturing products is uncertain and limited. We carry on theoretical analysis of this model and perform numerical simulations from the perspective of entropy theory. Results show that a precipitous speed of recycling price adjustment of the manufacturer or the third-party will both lead the system into a chaotic state and cause the entropy of the system to increase. The system is sensitive to initial conditions in this chaotic condition. Focusing on the harmful effects of chaotic system, we introduce adjustment parameter to efficiently control the chaos. The results have a strong reference value to practical problems, so it has a great value in both theory and application
The Impact of School Education on Depressive Symptoms in Chinese Adolescents: a Prospective Longitudinal Study
There is a growing but limited literature on psychological distress among Chinese students, especially the impact of the COVID-19 pandemic, using a longitudinal comparison between in school and at home. This study aimed to assess the psychological status of adolescents in school and related risk and protective factors. We surveyed 13,637 adolescents before the COVID-19 outbreak (T1) and 10,216 after two months of home confinement (T2). The 9-item Patient Health Questionnaire (PHQ-9) was used to assess depressive symptoms or the severity of depression among the adolescents. In addition, the Childhood Trauma Questionnaire and the Connor-Davidson Resilience Scales were also used to screen for experiences of abuse and neglect and to measure resilience in adolescents. At baseline, 22.34% reported depressive symptoms. At T2, this rate decreased to 14.86%. When adolescents were in school, age (P < .0001), gender (P < .0001), and experience of abuse (P < .0001) were risk factors, while parent-child relationship (P < .0001), and resilience (P < .0001) were protective factors for depressive symptoms. After leaving school, age and physical abuse were no longer risk factors for depression. The negative impact of school education on the mental health of adolescents in China exceeds even the impact of the pandemic and home isolation. The focus should be on those adolescents with abuse experience and poor parent-child relationships to prevent the onset of psychological and psychiatric disorders
Baseline BMI is associated with clinical symptom improvements in first-episode schizophrenia: a longitudinal study
Background: There is sufficient evidence of the high prevalence of obesity in schizophrenia (SZ) compared to the general population. Previous studies have reported that weight gain correlated with the response to antipsychotics in patients with SZ. Nonetheless, the relationship between body mass index (BMI) and therapeutic benefits remains unclear. This study was designed to investigate the association between baseline BMI and improvements in clinical symptoms after treatment with antipsychotics in first-episode and medication-naĂŻve SZ (FEMNS).Methods: A total of 241 FEMNS patients were enrolled and received risperidone over 12Â weeks. The severity of symptoms was assessed by the Positive and Negative Syndrome Scale (PANSS) and BMI was measured at baseline and 12-week follow-up.Results: We found that risperidone treatment raised the body weight of FEMNS patients and baseline BMI was negatively correlated with the improvement in negative symptoms (r = â0.14, p = 0.03) after 12-week treatment. Linear regression analysis indicated that baseline BMI was an independent predictor of response to risperidone in the early stage of SZ.Conclusion: The current study suggests a close relationship between baseline BMI and improvement in negative symptoms in SZ
A novel laboratory-based nomogram for assessing infection presence risk in acute-on-chronic liver failure patients
Abstract Accurate assessment of infection presence risk level, timely diagnosis, and effective control are critical for decreasing mortality of Acuteâonâchronic liver failure (ACLF). We aimed to develop and validate a novel diagnostic model to accurately assess infection presence risk level in ACLF patients. 185 ACLF patients with/without infection were enrolled, and their demographic, physical findings, immune-inflammatory, hepatic function, metabolism, and coagulation-fibrinolysis indicators were analyzed. Regression analysis was performed to identify the independent diagnostic parameters, which were further used to establish diagnostic models with a nomogram for visual. An area under receiver operating characteristic curve (AUROC), calibration plots, clinical impact curves, decision curve analysis, and net reclassification index were used to evaluate and identify the best model. An external validating cohort was introduced to verify the diagnostic accuracy. We screened out white blood cell (WBC) count, LYM%, blood urea nitrogen (BUN), and D-dimer for assessing infection presence risk levels in ACLF patients. WBD (WBCâ+âBUNâ+âD-dimer) was established and proposed as a novel diagnostic model for infection presence risk levels assessment in ACLF patients with an AUROC of 0.803 (95%CI 0.723â0.883), 0.885 (95%CI 0.786â0.984) in training and external cohorts, respectively. In stratification analysis by ACLF etiology and stages, WBD achieved an AUROC of 0.791 (95%CI 0.691â0.891) and 0.873 (95%CI 0.78â0.966) in HBV-related and early-stage patients, respectively. Whereas a higher AUROC of 0.905 (95%CI 0.807â1.00) in the early-stage of HBV-related ACLF patients indicated its optimum application scope. WBD, a novel laboratory-based nomogram, can serve as a decision-making support tool for clinicians to assess infection presence risk levels in ACLF patients
The Effects of Intensive Nutrition Education on Late Middle-Aged Adults with Type 2 Diabetes
Objective: Many patients with type 2 diabetes find it difficult to maintain good glycemic control. Undesirable glycemic control occurs greatly due to deficiencies of nutritional knowledge and difficulty in obtaining dietary prescriptions. The late middle-aged and elder individuals are the main populations that are affected by type 2 diabetes. The main purpose of this study was to investigate whether intensive nutrition education would make benefits for late middle-aged patients with type 2 diabetes. Method: 196 patients between 50 to 65 years old meeting type 2 diabetes criteria and eligible for the program were included in a single-blinded, 30-day centralized management of an education program in China. Participants in the program were randomly divided into a usual nutrition education group or an intensive nutrition education group. The usual nutrition education group was used as a control group and received only basic health advice and principles of diabetic diets at the beginning and the end of the study. Participants in the intensive nutrition education group were arranged to receive intensive nutritional lectures about diabetes for 30 days. The primary outcomes were the changes in weight, body mass index (BMI), fasting plasma glucose (FPG), 2-h postprandial plasma glucose (PG), glycosylated hemoglobin (HbA1c), total glycerin (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c). Results: After 30 days of intervention, FPG, PG, and HbA1c in the treatment group decreased significantly than the control group (p < 0.05). HbA1c reduced significantly by 0.6% in the intervention group. No significant differences in the change of blood lipids were observed between groups. However, TG, TC, and HDL-c made improvements compared with the baseline in the experimental group. Both groups had a reduction in weight and BMI within groups, especially in intensive nutrition education group. However, there was no statistical significance between groups. Conclusions: Intensive nutrition education has significant effects on blood glucose control in late middle-aged adults with type 2 diabetes. Intensive education can cultivate good diet habits and increase physical activity, which are important for diabetes patients in the short and long terms. These findings may contribute to improving education methodology and nutrition therapy in patients with type 2 diabetes
Modification of graphene oxide by ATRP: A pH-responsive additive in membrane for separation of salts, dyes and heavy metals
Incorporation of hydrophilic multifunctional compounds in to the polymeric membrane's matrix is one of the useful methods for modification of mixed matrix membranes. Therefore, in this study, preparation and properties of polyethersulfone (PES) mixed matrix membranes with hydrolyzed polymethylmethacrylate (PMMA(hyd)) grafted on graphene oxide (GO-PMMA(hyd)) is investigated as an effective additive to improve permeability and antifouling properties. In this respect, grafting of PMMA(hyd) on the GO surface is done by atom transfer radical polymerization (ATRP) technique and confirm by FTIR, H NMR, EDAX and thermogravimetric analysis (TGA). During membrane formation, the membrane surface porosity improves and the hydrophilic GO-PMMA(hyd) nanoparticles tend to migrate toward the membrane top surfaces which confirms by FE-SEM cross-section images. Moreover, contact angle measurements show that the surface hydrophilicity enhanced after introducing GO-PMMA(hyd). More importantly, prepared nanocomposite membranes show excellent performance in the separation of salts, dyes and heavy metal ions. Furthermore, it can be expected that by creating acid groups on graphene oxide plates, prepared mixed matrix membranes were pH-sensitive, so this claim is examined and proved in membranes