Effect of berberine chloride on caspase-3 dependent apoptosis and antioxidant capacity in the hippocampus of the chronic cerebral hypoperfusion rat model

Objective(s): The main goal of the current research was to examine the effects of Berberine (BBR) on apoptotic signaling and hippocampal oxidative stress induced by common carotid artery occlusion. Materials and Methods: Chronic cerebral hypoperfusion (CCH) model was created by occluding the two common carotid arteries (two-vessel occlusion 2VO) permanently. BBR (50 and 100 mg/kg/daily) was intra-gastrically administered to ischemic rats. Neuronal survival was evaluated by Nissl staining. The levels of malondialdehyde (MDA) and antioxidant enzymes, including catalase (CAT) and superoxide dismutase (SOD), along with the activities of caspase 3 were estimated in the hippocampus 2 month after treating the rats with 2VO. Results: According to findings of the present research, the BBR therapy inhibited the neurodegeneration of hippocampus. BBR also significantly decreased the amount of MDA and activity of caspase 3 in the hippocampus. Furthermore, the administration of BBR alleviated the lowered activities of SOD and CAT after 2VO surgery. Conclusion: The antioxidant and antiapoptotic properties of BBR might play important roles in improving functional outcomes and might have significant neuroprotective effects on the CCH damage. © 2019, Mashhad University of Medical Sciences. All rights reserved

Effect of berberine chloride on caspase-3 dependent apoptosis and antioxidant capacity in the hippocampus of the chronic cerebral hypoperfusion rat model

Objective(s): The main goal of the current research was to examine the effects of Berberine (BBR) on apoptotic signaling and hippocampal oxidative stress induced by common carotid artery occlusion. Materials and Methods: Chronic cerebral hypoperfusion (CCH) model was created by occluding the two common carotid arteries (two-vessel occlusion 2VO) permanently. BBR (50 and 100 mg/kg/daily) was intra-gastrically administered to ischemic rats. Neuronal survival was evaluated by Nissl staining. The levels of malondialdehyde (MDA) and antioxidant enzymes, including catalase (CAT) and superoxide dismutase (SOD), along with the activities of caspase 3 were estimated in the hippocampus 2 month after treating the rats with 2VO. Results: According to findings of the present research, the BBR therapy inhibited the neurodegeneration of hippocampus. BBR also significantly decreased the amount of MDA and activity of caspase 3 in the hippocampus. Furthermore, the administration of BBR alleviated the lowered activities of SOD and CAT after 2VO surgery. Conclusion: The antioxidant and antiapoptotic properties of BBR might play important roles in improving functional outcomes and might have significant neuroprotective effects on the CCH damage. © 2019, Mashhad University of Medical Sciences. All rights reserved

Model of optimization of mining complex for the planning of flow of quarry production of limestone in multiple products and with elements for the analysis of the capacity

Activities in mining complexes contain multiple decisions that affect the operations of the system for the extraction, transformation, transport and storage of various subsoil components. The purpose of this research is the planning of continuous flow production systems for mixed products, in non-metallic mining extraction processes, considering bottlenecks and capacity planning. This paper presents a model for production, based on mathematical optimization, that facilitates the planning and management of operations in the area of extraction, crushing and transformation of a quarry of aggregates for construction, considering the resources and the constraints that allow to define effective strategies in the increase of the productivity of the lines of low production environment by scenarios. This research develops an analysis of bottlenecks and contrasts the nature of the production system by means of a mathematical model of optimization, which considers the capacities and balances in the flows of the Limestone production line. The mathematical model that maximizes profits can be adapted to systems of continuous flow production in mining complexes where their products are part of a reverse logistics process, analysis of alternatives of extraction, transformation and transport