Requirement of a new substation based protective relay coordination

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The Role of Public Urban Spaces in Creating a Vivacious Society: A Case Study in Tabriz, Iran

Public spaces are an arena for displaying the flow of human life. Social interactions with triple classifications including compulsory, optional and social activities take place in these spaces. The issue that we will review in the present discussion refers to lack of public lively spaces for doing optional-recreative activities in Tabriz. First, public urban spaces and necessity of their existence in creating a lively and spirited environment will be described. Second, we will discuss the subject of virtual world and its impact on redefining of social relations, and disruption of the recent generation from the past one. Then with reviewing the available spaces in the city and their analysis, and also regarding different factors, we will try to provide appropriate solutions and new ideas in creating new spaces which will altogether take into account the issues of recreation, welfare, peace, interaction, art and virtual world. The results show that the inadequacy of the public spaces with a recreational approach is felt in urban arena and inside the dense context of Tabriz regarding its large scale in comparison with other megalopolises

The Role of Public Urban Spaces in Creating a Vivacious Society: A Case Study in Tabriz, Iran

Public spaces are an arena for displaying the flow of human life. Social interactions with triple classifications including compulsory, optional and social activities take place in these spaces. The issue that we will review in the present discussion refers to lack of public lively spaces for doing optional-recreative activities in Tabriz. First, public urban spaces and necessity of their existence in creating a lively and spirited environment will be described. Second, we will discuss the subject of virtual world and its impact on redefining of social relations, and disruption of the recent generation from the past one. Then with reviewing the available spaces in the city and their analysis, and also regarding different factors, we will try to provide appropriate solutions and new ideas in creating new spaces which will altogether take into account the issues of recreation, welfare, peace, interaction, art and virtual world. The results show that the inadequacy of the public spaces with a recreational approach is felt in urban arena and inside the dense context of Tabriz regarding its large scale in comparison with other megalopolises

Triage Systems in Mass Casualty Incidents and Disasters: A Review Study with A Worldwide Approach

BACKGROUND: Injuries caused by emergencies and accidents are increasing in the world. To prioritise patients to provide them with proper services and to optimally use the resources and facilities of the medical centres during accidents, the use of triage systems, which are one of the key principles of accident management, seems essential. AIM: This study is an attempt to identify available triage systems and compare the differences and similarities of the standards of these systems during emergencies and disasters through a review study. METHODS: This study was conducted through a review of the triage systems used in emergencies and disasters throughout the world. Accordingly, all articles published between 1990 and 2018 in both English and Persian journals were searched based on several keywords including Triage, Disaster, Mass Casualty Incidents, in the Medlib, Scopus, Web of Science, Pubmed, Cochrane Library, Science Direct, Google scholar, Irandoc, Magiran, Iranmedex, and SID databases in isolation and in combination using both and/ or conjunctions. RESULTS: Based on the search done in these databases, twenty different systems were identified in the primary adult triage field including START, Homebush triage Standard, Sieve, Care Flight, STM, Military, CESIRA Protocol, MASS, Revers, CBRN Triage, Burn Triage, META Triage, Mass Gathering Triage, SwiFT Triage, MPTT, TEWS Triage, Medical Triage, SALT, mSTART and ASAV. There were two primary triage systems including Jump START and PTT for children, and also two secondary triage systems encompassing SAVE and Sort identified in this respect. ESI and CRAMS were two other cases distinguished for hospital triage systems. CONCLUSION: There are divergent triage systems in the world, but there is no general and universal agreement on how patients and injured people should be triaged. Accordingly, these systems may be designed based on such criteria as vital signs, patient's major problems, or the resources and facilities needed to respond to patients’ needs. To date, no triage system has been known as superior, specifically about the patients’ clinical outcomes, improvement of the scene management or allocation of the resources compared to other systems. Thus, it is recommended that different countries such as Iran design their triage model for emergencies and disasters by their native conditions, resources and relief forces

High carrier frequency of the GJB2 mutation (35delG) in the north of Iran

Objective: Mutations in the GJB2 gene are a major cause of autosomal recessive and sporadic non-syndromic hearing loss in many populations. A single mutation of this gene (35delG) accounts for approximately 70% of mutations in Caucasians with a carrier frequency of 2-4% in Europe. This study aims to determine the rate of 35delG carrier frequency in Iran. Methods: Genomic DNA was extracted from a total of 550 unaffected unrelated subjects from 4 provinces of Iran following the standard phenol chloroform procedure. The one base pair deletion (35delG) was analysed using a nested PCR procedure; 35delG mutation carriers were subsequently confirmed by sequence analysis. Moreover, using the Binomial probability distribution, we compared the 35delG carrier frequency of Iranian population with the various Middle Eastern and overall European populations. Results: Of the four populations studied, we found a high carrier frequency of 2.8% in Gilan province in the north of Iran. The overall 35delG carrier frequency was found to be 1.25% in the populations studied (our present and previous data) which is similar to the overall 35delG carrier frequency detected in Middle Eastern populations, but Significantly tower than that identified in European populations. (c) 2007 Elsevier Ireland Ltd. All rights reserved

Molecular characterization of familial hypercholesterolemia in Iranian patients

Abstract Familial hypercholesterolemia (FH) is an autosomal dominant disorder of lipoprotein metabolism caused mainly by mutations in the low-density lipoprotein receptor (LDLR) and apolipoprotein B 100 (APOB) genes. Until now, the molecular basis of FH has been demonstrated in detail in many populations, but there is still very limited Molecular data concerning FH in Iran. The aim of this study was to characterize the LDLR and APOB gene mutations in an Iranian population. A total of 30 non-related Iranian possible FH subjects were studied. Diagnosis of FH was based on the Dutch Lipid Clinic Network diagnostic criteria. All samples were initially tested for three common APOB gene mutations including R3500Q, R3500 W and R3531C using PCR-RFLP assay. Subsequently, promoter and coding region of the LDLR gene was screened by PCRSSCP analysis and positive results were confirmed by DNA sequencing. Four previously reported polymorphisms 1413G [A, 1725C [T, 1773T [C and 2140 ? 5G[A were found in *17% (5/30) of population studied. Moreover, no variation was found in APOB gene. Our data indicated that LDLR and APOB gene mutations have not contribution to possible FH in Iranian population studied here. However, we examined three common APOB mutations and LDLR in only 30 patients, and to determine the role of these genes in developing FH in Iran, more FH samples and populations needed to be investigated for the mutations of the related gene

Molecular pathology of 6 novel GJB2 allelic variants detected in familial and sporadic Iranian non syndromic hearing loss cases

Background: Mutations of GJB2 gene encoding connexion 26 are the most common cause of hearing loss in many populations. A very wide spectrum of GJB2 gene mutations associated with hearing loss have been detected but pathogenic role has been tested only for a part of them. In this study, we have provided genetic evidence on the pathogenicity of our previously reported novel GJB2 allelic variants. Methods: The pathogenic role of GJB2 allelic variants were assessed using co segregation of each allelic variant with hearing loss in family members, absence of the allelic variants in control populations, coexistence with a second GJB2 mutation, nature of the amino acid substitution and evolutionary conservation of the appropriate amino acid. Results: The GJB2 allelic variants including 363delC, 327delGGinsA, H16R and G200R have been co segregated with autosomal recessive non syndromic hearing loss in five families and are not found in control subjects. The G130V and K102Q were found in heterozygous state in two deaf individuals. G130V results in an exchange a residue highly conserved among all the connexins but was found with a rate of 1% in control subjects and K102Q results in an exchange a residue not conserved among all the connexins and not identified in control subjects. Conclusion: We conclude that, 363delC, 327delGGinsA, H16R and G200R may be pathogenic. However, the pathogenicity and inheritance of K102Q and G130V can not be assessed clearly and remains to be identified

Study of two common P53 gene mutations in gastric cancer using PCR-RFLP in Chaharmahal va Bakhtiari province, Iran, 2003

Background and aim: Gastric cancer is the most common cause of cancer death world wide after lung cancer. Genetic factors including oncogenes and tumor suppressor genes are always involved in progression of this cancer. The P53 tumor suppressor gene is believed to have a broad role in the cell such as programmed cell death and stop cell replicating damaged DNA which has been summarized as the guardian of the genome. This study aims to determine the frequency of two common P53 gene mutations using PCR-RFLP in gastric cancer in Chaharmahal va Bakhtiari province. Methods: This descriptive – lab based study describes the mutation analysis of paraffin embedded gastric samples from 38 patients in Chaharmahal va Bakhtiari province. We have investigated the frequency of P53 gene mutation in exons 7 and 8 by PCR-RFLP to detect alteration in two common hot spots in codon 248 and 282. Results: We determined no mutation in P53 gene hot spots in codon 248 and 282. Conclusion: We conclude that association of P53 gene mutations with gastric cancer is very low in Chaharmahal va Bakhtiari province. However we have examined only 38 gastric samples and more samples need to be investigated to reveal the contribution of P53 gene mutation in causing gastric cancer in this province. Also it is necessary to study the entire coding region and promoter of the gene in patients from different population and ethnic groups

Bushehr Elderly Health (BEH) Programme, phase I (cardiovascular system)

Purpose: The main objective of the Bushehr Elderly Health Programme, in its first phase, is to investigate the prevalence of cardiovascular risk factors and their association with major adverse cardiovascular events. Participants: Between March 2013 and October 2014, a total of 3000 men and women aged ≥60 years, residing in Bushehr, Iran, participated in this prospective cohort study ( participation rate=90.2%). Findings to date: Baseline data on risk factors, including demographic and socioeconomic status, smoking and medical history, were collected through a modified WHO MONICA questionnaire. Vital signs and anthropometric measures, including systolic and diastolic blood pressure, weight, height, and waist and hip circumference, were also measured. 12-lead electrocardiography and echocardiography were conducted on all participants, and total of 10 cc venous blood was taken, and sera was separated and stored at –80°C for possible future use. Preliminary data analyses showed a noticeably higher prevalence of risk factors among older women compared to that in men. Future plans: Risk factor assessments will be repeated every 5 years, and the participantswill be followed during the study to measure the occurrence of major adverse cardiac events. Moreover, the second phase, which includes investigation of bone health and cognition in the elderly, was started in September 2015. Data are available at the Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran, for any collaboratio