Manufacturing Biocomposites Using Black Pine Bark and Oak Bark

Bark as a biowaste has a huge availability throughout the world and has had limited use in industrial applications. Black pine bark and oak bark were considered in this work. The aim was to manufacture a new biocomposite with different combination of black pine bark, oak bark, polypropylene, polyethylene, and a coupling agent, and to determine some physical and mechanical properties of the manufactured biocomposites. Density, thickness swelling, water absorption, tension strength, modulus of rapture and modulus of elasticity in bending and tension of the biocomposites were determined. According to the results, thickness swelling and water absorption properties were improved up to 80% when compared with wood-plastic composites (WPC) produced with wood flour. Although the new biocomposites displayed lower mechanical performance in comparison of biocomposites made with wood flour, the observed results were satisfactory. Based on the results of this study, black pine bark and oak bark can be used as filler materials in WPCs production. Hereby, these bark materials can be the raw material for value-added products. Bark use in biocomposite production also can contribute to reduced requirements of wood material and petroleum products

Manufacturing Biocomposites Using Black Pine Bark and Oak Bark

Bark as a biowaste has a huge availability throughout the world and has had limited use in industrial applications. Black pine bark and oak bark were considered in this work. The aim was to manufacture a new biocomposite with different combination of black pine bark, oak bark, polypropylene, polyethylene, and a coupling agent, and to determine some physical and mechanical properties of the manufactured biocomposites. Density, thickness swelling, water absorption, tension strength, modulus of rapture and modulus of elasticity in bending and tension of the biocomposites were determined. According to the results, thickness swelling and water absorption properties were improved up to 80% when compared with wood-plastic composites (WPC) produced with wood flour. Although the new biocomposites displayed lower mechanical performance in comparison of biocomposites made with wood flour, the observed results were satisfactory. Based on the results of this study, black pine bark and oak bark can be used as filler materials in WPCs production. Hereby, these bark materials can be the raw material for value-added products. Bark use in biocomposite production also can contribute to reduced requirements of wood material and petroleum products

Relation between serum sodium levels and clinical outcomes in Turkish patients hospitalized for heart failure: a multi-center retrospective observational study

Objective: The purpose of the study was to analyze the prevalence of hyponatremia and related 1-year outcomes of patients hospitalized for decompensated heart failure with reduced ejection fraction (HFrEF) in Turkish patients. Methods: A total of 500 hospitalized patients with HFrEF were consecutively included in a retrospective study at 19 participating hospitals. Patients were categorized according to their serum sodium levels (sNa) on admission day as normonatremic (135-145 mEq/L) and hyponatremic (< 135 mEq/L). One-year all-cause mortality, re-hospitalization rates, and the impact of the changes in sNa at the time of discharge to clinical outcomes were examined. Results: Hyponatremia was observed in 29% of patients. Patients with hyponatremia had lower blood pressures, creatinine clearance, and left ventricular ejection fraction and higher serum creatinine and BUN levels on admission compared with those with normonatremia. Hyponatremia was associated with higher 1-year all-cause mortality (14% vs. 2.6%, p= 135 mEq/L). Those with persistent hyponatremia had the highest all-cause mortality (p< 0.001). Conclusion: In this study, it is demonstrated that hyponatremia is relatively common and is associated with increased 1-year all-cause mortality and re-hospitalization rates among Turkish patients hospitalized with HFrEF. Approximately 50% of the patients with initial low sNa had persistent hyponatremia at discharge, and these patients had the worst clinical outcomes

Risk assessment and survival of patients with pulmonary hypertension: Multicenter experience in Turkey

Objective: Risk stratification continues to evolve in pulmonary arterial hypertension (PAH). Our aim was to further confirm the risk assessment strategy in our cohort and to determine the most reliable model

Predictors of Complex Aortic Plaques in Patients Undergoing Transoesophageal Echocardiography

Introduction: Atrial fibrillation (AF) is one of the most important causes of ischaemic stroke according to the TOAST classification. The CHA(2)DS(2)-VASc score is a widely used scoring system for estimating systemic thromboembolism in patients with non-valvular AF. TOAST classification indicates that an ischaemic stroke may also be due to large artery atherosclerosis. Since some of the atherosclerotic risk factors also occur in the CHA(2)DS(2)-VASc scoring system, we hypothesised that this scoring system can also predict the presence of complex aortic plaques and their stroke risk

Circulating miR-21 and eNOS in subclinical atherosclerosis in patients with hypertension

Objectives: The aim of this study is to evaluate the relationship of miR-21, nitric oxide (NOx) and endothelial nitric oxide synthase (eNOS) with subclinical atherosclerosis in carotid arteries by measuring carotid intima media thickness (CIMT) in patients with hypertension and healthy controls. Design and Methods: A total of 28 hypertensive and 28 healthy controls were enrolled. MiR-21 expression was analyzed by quantitative reverse transcription-PCR and NOx, and eNOS levels were measured by ELISA assay. CIMT was evaluated by ultrasonography and CIMT0.8mm was accepted as increased CIMT (iCIMT). Results: C-reactive protein (CRP) level, plasma miR-21 expression level and CIMT were found to be significantly higher in the hypertension group when compared to the control group (p=0.009, p=0.002 and p<0.001, respectively). NOx and eNOS levels were significantly lower in the hypertension group compared to the control group (p<0.001, both). MiR-21 level was positively correlated with the clinical systolic blood pressure, clinical diastolic blood pressure, CRP and CIMT. MiR-21 was also negatively correlated with NOx and eNOS. Eighteen patients with hypertension had iCIMT. MiR-21 and CRP levels were significantly higher (p<0.001 and p=0.001), whereas NOx and eNOS levels were significantly lower in patients with iCIMT (p<0.001, both). Conclusion: The decreased levels of NOx and eNOS found in this study indicate the co-existence of endothelial dysfunction and hypertension once more. In the absence of microalbuminuria, the increased miR-21 expression in patients with iCIMT made us conclude that this miRNA might be involved in the early stages of atherosclerotic process in hypertensive patients

Sunitinib for Patients with Metastatic Non-clear Cell Renal Cell Carcinoma: A Multicenter Retrospective Turkish Oncology Group Trial

Aim: This study aimed to assess the clinical efficacy and toxicity of sunitinib, a targeted-agent, for non-clear cell renal cell carcinoma. Patients and Methods: Sixty-three patients with complete clinical data from 13 oncology Centers were retrospectively evaluated. Outcomes analyzed were objective response rate (ORR), progression-free survival (PFS), overall survival (OS) and adverse events. Results: The median age of all patients, 38 men (60.3%) and 25 women (39.7%), was 63 years (range=25-82 years). Histological subtypes included 46 (88%) cases of papillary RCC, 10 of chromophobe, and 7 unclassified cases. Median treatment duration was seven months (range=2-86 months). At the time of this analysis, 52 patients had discontinued treatment, 33 of whom had died. Treatment discontinuation was due to disease progression in 43 patients, and toxicity in nine. Dose interruption was necessary in 22 (34.9%) patients, and dose reduction in 27 (42.9%). The objective response rate and disease control rate were 11.1% and 63.5%, respectively. The median PFS and OS were 7.6 months (95% confidence interval (CI)=5.5-9.7 months) and 22.0 months (95% CI=13.4-30.6 months), respectively, with 1-year rates of 64.7% and 33.7%, respectively. Conclusion: Clinical outcome of the metastatic non-clear cell RCC patients with sunitinib treatment seemed to be worse than the historical data of clear cell RCC patients, in terms of PFS, OS and objective response. New and more effective targeted-therapies and better understanding of the underlying molecular processes are necessary to improve survival outcome for these patients