8 research outputs found
Aesthetics and Politics of Feminist Tragic Narratives at the Turn of the Nineteenth-Century into the Twentieth
Abstract My dissertation focusses on American feminist tragic novels between 1890 and 1925, which deal with women’s tragic lives in a patriarchal society. I will show that the thematic and structural similarities among them are evident to the extent that they seem to build a particular literary tradition different from other similar genres, such as sentimental novels, naturalist novels, and classic tragedies. Based on the field of generic criticism, I define the new tradition as the genre of feminist tragic novels in which a feminist consciousness is manifested in terms of tragic vision and contentious structure. The specific generic approach to these novels leads to an analysis of their genre-unique aesthetic values, which justify their status as artistic works. For this purpose, I clarify the historical long-held aversion of critics to women writers’ realistic work through the variety of critical and aesthetics lenses. I explore how the male dominated process of American literary canonization, centering on Romance theory and masculine myths on one side and traditional aesthetics such as Genius theory and Disinterestedness on the other, have hindered women’s tragic novels from being interpreted aesthetically or rhetorically. These clarifications show how these feminist tragic novels, and their authors, create counter-discourse to previous genres by making gendered claims not only on the patriarchal society they live in, but also on the genre they write in. To show this, I begin with two novels that end with the suicide of the female protagonists: Kate Chopin’s The Awakening (1899) and Edith Wharton’s The House of Mirth (1905). In the first chapter, I will show how women’s suicides serve as a vehicle to let readers experience the emancipation of ethics, rather than that of emotion. In the second chapter, I deal with the issues of women’s mental breakdown in feminist tragic fiction by Charlotte Perkins Gilman, “The Yellow Wallpaper” (1892), and Gertrude Stein, “Melanctha” (1909), focusing on the way linguistic devices and narratology draw attention to the chasm between women’s desire and social oppression. In the third chapter, by closely reading Edith Summers Kelley’s Weeds (1923) and Ellen Glasgow’s Barren Ground (1925), I show how women’s adversities in the feminist tragic novels are depicted in a way that raises readers’ social consciousness, rather than allowing them to transcend or sublimate it, drawing on the aesthetic of dissensus. In each case, I define the feminist tragic novels as cultural products that represent their materiality, while simultaneously becoming a source from which new meaning is produced in both a dialectical and a revolutionary way
Association between Unplanned Conversion and Patient Survival after Laparoscopic Liver Resection for Hepatocellular Carcinoma: A Propensity Score Matched Analysis
Unplanned conversion (UPC) is considered to be a predictor of poor postoperative outcomes. However, the effects of UPC on the survival of patients with hepatocellular carcinoma (HCC) remain controversial. The aim of this study is to compare the outcomes between patients who underwent laparoscopic liver resection (LLR) and those who underwent UPC for HCC. Among 1029 patients with HCC who underwent hepatectomy between 2004 and 2021, 251 were eligible for the study. Of 251 patients who underwent hepatectomy for HCC in PS segments, 29 (26.0%) required UPC, and 222 underwent LLR. After 1:5 PSM, 25 patients were selected for the UPC group and 125 for the LLR group. Blood loss, transfusion rate, hospital stay, and postoperative complication were higher in the UPC group. Regarding oncologic outcomes, although the 5-year overall survival rate was similar in both groups (p = 0.544), the recurrence-free survival rate was lower in the UPC group (p < 0.001). UPC was associated with poor short-term as well as inferior long-term outcomes compared with LLR for HCC in PS segments. Therefore, surgeons must carefully select patients and consider early conversion if unexpected bleeding occurs to maintain safety and oncologic outcomes
A Prospective Analysis of the Effects of a Powder-Type Hemostatic Agent on the Short-Term Outcomes after Liver Resection
Background and Objectives: Postoperative bleeding is a significant cause of morbidity and mortality following liver resection. Therefore, it is crucial to minimize bleeding during liver resection and effectively manage it when it occurs. Arista® AH (Becton, Dickinson and Company, Franklin Lakes, NJ, USA) is a microporous polysaccharide hemosphere (MPH), a new plant-derived polysaccharide powder hemostat that can be applied to the entire surgical field. This study prospectively assessed the effectiveness of Arista for bleeding control when applied intraoperatively to the liver resection surface. Materials and Methods: Data were collected at Seoul National University Bundang Hospital for patients who underwent liver resection owing to malignant hepatocellular carcinoma or benign liver diseases. We compared the outcomes between 45 patients managed with Arista® AH (data were prospectively collected between September 2022 and May 2023) and 156 patients managed without the use of Arista® AH (data were retrospectively collected between January 2021 and December 2021). Results: There were no significant differences in patient characteristics between the two groups. The estimated blood loss (EBL) was significantly lower in the Arista® AH group compared with the control group (495.56 ± 672.7 mL vs. 691.9 ± 777.5 mL, p = 0.049). The mean postoperative hospital stay was significantly shorter in the Arista® AH group (5.93 ± 1.88 days vs. 6.94 ± 4.17 days, p = 0.024). The time to Jackson-Pratt drain removal was also significantly shorter in the Arista® AH group (4.64 ± 1.31 days vs. 5.30 ± 2.87 days, p = 0.030). The patient subgroup was divided into four categories based on the type of resection and the presence or absence of cirrhosis. Within the subgroup of major resections in non-cirrhotic patients, the Arista® AH group demonstrated significantly better outcomes compared to the control group, showed lower EBL, reduced need for blood transfusions, decreased volume of drain fluid collected within 48 h, earlier removal of drains, and shorter hospital stays. In contrast, for the other subgroups such as minor resection (both non-cirrhotic and cirrhotic) and major resection with cirrhosis, the differences between the Arista® AH and control groups in various parameters like EBL, blood transfusion rates, drain fluid volume, time to drain removal, and duration of hospital stay were not statistically significant. Conclusions: Arista® AH significantly improved intraoperative blood management and postoperative recovery in patients undergoing liver resection, particularly in non-cirrhotic patients who underwent major resection
Comparative Study of Long-Term Outcomes of Laparoscopic Liver Resection versus Radiofrequency Ablation for Single Small Hepatocellular Carcinoma Located in Left Lateral Segments of the Liver
Background and Objectives: Laparoscopic liver resection (LLR) is now widely recognized as the primary surgical option for hepatocellular carcinomas (HCC) smaller than 3 cm located in the left lateral segment of the liver. Nevertheless, there is a scarcity of studies comparing laparoscopic liver resection with radiofrequency ablation (RFA) in these cases. Materials and Methods: We retrospectively compared the short- and long-term outcomes of Child–Pugh class A patients who underwent LLR (n = 36) or RFA (n = 40) for a newly diagnosed single small (≤3 cm) HCC located in the left lateral segment of the liver. Results: Overall survival (OS) was not significantly different between the LLR and RFA groups (94.4% vs. 80.0%, p = 0.075). However, disease-free survival (DFS) was better in the LLR group than in the RFA group (p p p = 0.031) and DFS (68.8% vs. 20.0%, p = 0.002) rates were greater in the LLR group. Conclusions: LLR showed superior OS and DFS compared to RFA in patients with a single small HCC situated in the left lateral segment of the liver. LLR can be considered for patients with an α-fetoprotein level of ≥20 ng/mL
Development and Validation of a Difficulty Scoring System for Laparoscopic Liver Resection to Treat Hepatolithiasis
Background and Objectives: A difficulty scoring system was previously developed to assess the difficulty of laparoscopic liver resection (LLR) for liver tumors; however, we need another system for hepatolithiasis. Therefore, we developed a novel difficulty scoring system (nDSS) and validated its use for predicting postoperative outcomes. Materials and Methods: This was a retrospective study. We used clinical data of 123 patients who underwent LLR for hepatolithiasis between 2003 and 2021. We analyzed the data to determine which indices were associated with operation time or estimated blood loss (EBL) to measure the surgical difficulty. We validated the nDSS in terms of its ability to predict postoperative outcomes, namely red blood cell (RBC) transfusion, postoperative hospital stay (POHS), and major complications defined as grade ≥IIIa according to the Clavien–Dindo classification (CDC). Results: The nDSS included five significant indices (range: 5–17; median: 8). The RBC transfusion rate (p p = 0.002), and major complication rate (p = 0.002) increased with increasing nDSS score. We compared the two groups of patients divided by the median nDSS (low: 5–7; high: 8–17). The operation time (210.7 vs. 240.7 min; p p p p = 0.001), and major complication rate (8.8% vs. 25.8%; p = 0.014) were greater in the high group. Conclusions: The nDSS can predict the surgical difficulty and outcomes of LLR for hepatolithiasis and may help select candidates for the procedure and surgical approach
Oncogenic function of p34SEI-1 via NEDD4-1-mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway
Semantic analysis on social networks: A survey
As social networks are getting more and more popular day by day, large numbers of users becoming constantly active social network users. In this way, there is a huge amount of data produced by users in social networks. While social networking sites and dynamic applications of these sites are actively used by people, social network analysis is also receiving an increasing interest. Moreover, semantic understanding of text, image, and video shared in a social network has been a significant topic in the network analysis research. To the best of the author's knowledge, there has not been any comprehensive survey of social networks, including semantic analysis. In this survey, we have reviewed over 200 contributions in the field, most of which appeared in recent years. This paper not only aims to provide a comprehensive survey of the research and application of social network analysis based on semantic analysis but also summarizes the state-of-the-art techniques for analyzing social media data. First of all, in this paper, social networks, basic concepts, and components related to social network analysis were examined. Second, semantic analysis methods for text, image, and video in social networks are explained, and various studies about these topics are examined in the literature. Then, the emerging approaches in social network analysis research, especially in semantic social network analysis, are discussed. Finally, the trending topics and applications for future directions of the research are emphasized; the information on what kind of studies may be realized in this area is given.WOS:0005265666000012-s2.0-8508344754