3,200 research outputs found
Determination of "structure-activity" relationship based on analysis of possible biological transformations of the "Triazavirin" drug
Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ ΡΠ΄ΠΎΠ±Π½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΡ
Π±ΠΈΠΎΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΉ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Β«Π’ΡΠΈΠ°Π·Π°Π²ΠΈΡΠΈΠ½Β», Π° ΡΠ°ΠΊΠΆΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° ΡΠ΅Π°ΠΊΡΠΈΡ Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ Π·Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π½ΠΈΡΡΠΎΠ³ΡΡΠΏΠΏΡ S- ΠΈ N-Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ»Π°ΠΌΠΈ. ΠΠΎΠΊΠ°Π·Π°Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π·Π°ΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π½ΠΈΡΡΠΎΠ³ΡΡΠΏΠΏΡ Π±ΠΈΠΎΠ³Π΅Π½Π½ΡΠΌΠΈ Π½ΡΠΊΠ»Π΅ΠΎΡΠΈΠ»Π°ΠΌΠΈ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΠΏΡΠ΅Π²ΡΠ°ΡΠ΅Π½ΠΈΡ Β«Π’ΡΠΈΠ°Π·Π°Π²ΠΈΡΠΈΠ½Π°Β» ΠΈ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ.Convenient methods for the preparation of possible biotransformation products of "Triazavirin" were developed, and biological activity of these compounds was investigated. The reaction of nitro-group nucleophilic substitution by S-and N-nucleophiles was studied. The possibility of nitro group substitution by biogenic nucleophilic agents was shown. The oxidative conversion of "Triazavirin" and the chemical properties of the products of oxidation were studied.ΠΡΠΎΠ³ΡΠ°ΠΌΠΌΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ Π£ΡΠ€Π£ Π½Π° 2013 Π³ΠΎΠ΄ (ΠΏ.2.1.2.1
Tuning the properties of complex transparent conducting oxides: role of crystal symmetry, chemical composition and carrier generation
The electronic properties of single- and multi-cation transparent conducting
oxides (TCOs) are investigated using first-principles density functional
approach. A detailed comparison of the electronic band structure of
stoichiometric and oxygen deficient InO, - and
-GaO, rock salt and wurtzite ZnO, and layered InGaZnO
reveals the role of the following factors which govern the transport and
optical properties of these TCO materials: (i) the crystal symmetry of the
oxides, including both the oxygen coordination and the long-range structural
anisotropy; (ii) the electronic configuration of the cation(s), specifically,
the type of orbital(s) -- , or -- which form the conduction band;
and (iii) the strength of the hybridization between the cation's states and the
p-states of the neighboring oxygen atoms. The results not only explain the
experimentally observed trends in the electrical conductivity in the
single-cation TCO, but also demonstrate that multicomponent oxides may offer a
way to overcome the electron localization bottleneck which limits the charge
transport in wide-bandgap main-group metal oxides. Further, the advantages of
aliovalent substitutional doping -- an alternative route to generate carriers
in a TCO host -- are outlined based on the electronic band structure
calculations of Sn, Ga, Ti and Zr-doped InGaZnO. We show that the
transition metal dopants offer a possibility to improve conductivity without
compromising the optical transmittance
Global gyrokinetic simulations of intrinsic rotation in ASDEX Upgrade Ohmic L-mode plasmas
Non-linear, radially global, turbulence simulations of ASDEX Upgrade (AUG)
plasmas are performed and the nonlinear generated intrinsic flow shows
agreement with the intrinsic flow gradients measured in the core of Ohmic
L-mode plasmas at nominal parameters. Simulations utilising the kinetic
electron model show hollow intrinsic flow profiles as seen in a predominant
number of experiments performed at similar plasma parameters. In addition,
significantly larger flow gradients are seen than in a previous flux-tube
analysis (Hornsby et al {\it Nucl. Fusion} (2017)). Adiabatic electron model
simulations can show a flow profile with opposing sign in the gradient with
respect to a kinetic electron simulation, implying a reversal in the sign of
the residual stress due to kinetic electrons. The shaping of the intrinsic flow
is strongly determined by the density gradient profile. The sensitivity of the
residual stress to variations in density profile curvature is calculated and
seen to be significantly stronger than to neoclassical flows (Hornsby et al
{\it Nucl. Fusion} (2017)). This variation is strong enough on its own to
explain the large variations in the intrinsic flow gradients seen in some AUG
experiments. Analysis of the symmetry breaking properties of the turbulence
shows that profile shearing is the dominant mechanism in producing a finite
parallel wave-number, with turbulence gradient effects contributing a smaller
portion of the parallel wave-vector
Model of Economic Phenomenon
As is known, economic phenomena represent the most important part of the subject of economic science. However, modern economic theory avoids a clear definition of this category. Thus, it remains unclear what is economic phenomena, and thus the economy is in its essence as suc
Tunable Conductivity and Conduction Mechanism in a UV light activated electronic conductor
A tunable conductivity has been achieved by controllable substitution of a
novel UV light activated electronic conductor. The transparent conducting oxide
system H-doped Ca12-xMgxAl14O33 (x = 0; 0.1; 0.3; 0.5; 0.8; 1.0) presents a
conductivity that is strongly dependent on the substitution level and
temperature. Four-point dc-conductivity decreases with x from 0.26 S/cm (x = 0)
to 0.106 S/cm (x = 1) at room temperature. At each composition the conductivity
increases (reversibly with temperature) until a decomposition temperature is
reached; above this value, the conductivity drops dramatically due to hydrogen
recombination and loss. The observed conductivity behavior is consistent with
the predictions of our first principles density functional calculations for the
Mg-substituted system with x=0, 1 and 2. The Seebeck coefficient is essentially
composition- and temperature-independent, the later suggesting the existence of
an activated mobility associated with small polaron conduction. The optical gap
measured remains constant near 2.6 eV while transparency increases with the
substitution level, concomitant with a decrease in carrier content.Comment: Submitted for publicatio
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