Region-Specific Vulnerability of the Amygdala to Injury-Induced Spreading Depolarization

Spreading depolarization (SD), a self-propagated wave of transient depolarization, regularly occurs in the cortex after acute brain insults and is now referred as an important diagnostic and therapeutic target in patients with acute brain injury. Here, we show that the amygdala, the limbic structure responsible for post-injury neuropsychological symptoms, exhibits strong regional heterogeneity in vulnerability to SD with high susceptibility of its basolateral (BLA) region and resilience of its centromedial (CMA) region to triggering SD by acute focal damage. The BLA micro-injury elicited SD twice as often compared with identical injury of the CMA region (71% vs. 33%). Spatiotemporal features of SDs triggered in the amygdala indicated diverse patterns of the SD propagation to the cortex. Our results suggest that even relatively small cerebral structures can exhibit regional gradients in their susceptibility to SD and the heterogeneity may contribute to the generation of complex SD patterns in the injured brain

Search for heavy neutral lepton production in K+K^+ decays

A search for heavy neutral lepton production in $K^+$ decays using a data sample collected with a minimum bias trigger by the NA62 experiment at CERN in 2015 is reported. Upper limits at the $10^{-7}$ to $10^{-6}$ level are established on the elements of the extended neutrino mixing matrix $|U_{\ell 4}|^2$ ($\ell=e,\mu$) for heavy neutral lepton mass in the range $170-448~{\rm MeV}/c^2$. This improves on the results from previous production searches in $K^+$ decays, setting more stringent limits and extending the mass range.A search for heavy neutral lepton production in K+ decays using a data sample collected with a minimum bias trigger by the NA62 experiment at CERN in 2015 is reported. Upper limits at the 10−7 to 10−6 level are established on the elements of the extended neutrino mixing matrix |Ue4|2 and |Uμ4|2 for heavy neutral lepton mass in the ranges 170–448 MeV/ c2 and 250–373 MeV/ c2 , respectively. This improves on the previous limits from HNL production searches over the whole mass range considered for |Ue4|2 , and above 300 MeV/ c2 for |Uμ4|2

First search for K+→π+ννˉK^+\rightarrow\pi^+\nu\bar{\nu} using the decay-in-flight technique

International audienceThe NA62 experiment at the CERN SPS reports the first search for K+→π+νν¯ using the decay-in-flight technique, based on a sample of 1.21×1011 K+ decays collected in 2016. The single event sensitivity is 3.15×10−10 , corresponding to 0.267 Standard Model events. One signal candidate is observed while the expected background is 0.152 events. This leads to an upper limit of 14×10−10 on the K+→π+νν¯ branching ratio at 95% CL

A search for the K+→μ−νe+e+K^+\to\mu^-\nu e^+e^+ decay

A search for the $K^+\to\mu^-\nu e^+e^+$ decay, forbidden within the Standard Model by either lepton number or lepton flavour conservation depending on the flavour of the emitted neutrino, has been performed using the dataset collected by the NA62 experiment at CERN in 2016--2018. An upper limit of $8.1\times 10^{-11}$ is obtained for the decay branching fraction at 90% CL, improving by a factor of 250 over the previous search

Search for lepton number and flavour violation in K+K^+ and π0\pi^0 decays

Searches for the lepton number violating $K^+ \to \pi^− \mu^+ e^+$ decay and the lepton flavour violating $K^+ \to \pi^+ \mu^- e^+$ and $\pi^0 \to \mu^- e^+$ decays are reported using data collected by the NA62 experiment at CERN in 2017$-$2018. No evidence for these decays is found and upper limits of the branching ratios are obtained at 90% confidence level: B($K^+ \to \pi^− \mu^+ e^+$) $K+→π-μ+e+ decay and the lepton flavor violating K+→π+μ-e+ and π0→μ-e+ decays are reported using data collected by the NA62 experiment at CERN in 2017–2018. No evidence for these decays is found and upper limits of the branching ratios are obtained at 90$K^{+} \rightarrow \pi^{-} \mu^{+} e^{+}$decay and the lepton flavour violating$K^{+} \rightarrow \pi^{+} \mu^{-} e^{+}$and$\pi^{0} \rightarrow \mu^{-} e^{+}$decays are reported using data collected by the NA62 experiment at CERN in$2017$-$2018$. No evidence for these decays is found and upper limits of the branching ratios are obtained at 90$\mathcal{B}(K^{+}\rightarrow\pi^{-}\mu^{+}e^{+})<4.2\times 10^{-11}$,$\mathcal{B}(K^{+}\rightarrow\pi^{+}\mu^{-}e^{+})<6.6\times10^{-11}$and$\mathcal{B}(\pi^{0}\rightarrow\mu^{-}e^{+})<3.2\times 10^{-10}$. These results improve by one order of magnitude over previous results for these decay modes

A search for the K+→μ−νe+e+K^+\to\mu^-\nu e^+e^+ decay

A search for the $K^+\to\mu^-\nu e^+e^+$ decay, forbidden within the Standard Model by either lepton number or lepton flavour conservation depending on the flavour of the emitted neutrino, has been performed using the dataset collected by the NA62 experiment at CERN in 2016--2018. An upper limit of $8.1\times 10^{-11}$ is obtained for the decay branching fraction at 90% CL, improving by a factor of 250 over the previous search

Measurement of the very rare K+→π+ννˉK^+\rightarrow\pi^+\nu\bar{\nu} decay

The NA62 experiment reports the branching ratio measurement BR$(K^+ \rightarrow \pi^+ \nu\bar{\nu}) = (10.6^{+4.0}_{-3.4} |_{\rm stat} \pm 0.9_{\rm syst}) \times 10 ^{-11}$ at 68% CL, based on the observation of 20 signal candidates with an expected background of 7.0 events from the total data sample collected at the CERN SPS during 2016-2018. This provides evidence for the very rare $K^+ \rightarrow \pi^+ \nu\bar{\nu}$ decay, observed with a significance of 3.4$\sigma$. The experiment achieves a single event sensitivity of $(0.839\pm 0.054)\times 10^{-11}$, corresponding to 10.0 events assuming the Standard Model branching ratio of $(8.4\pm1.0)\times10^{-11}$. This measurement is also used to set limits on BR($K^+ \to \pi^+ X$), where $X$ is a scalar or pseudo-scalar particle. Details are given of the analysis of the 2018 data sample, which corresponds to about 80% of the total data sample

Search for π0\pi^0 decays to invisible particles

The NA62 experiment at the CERN SPS reports a study of a sample of $4 \times 10^9$ tagged $\pi^0$ mesons from $K^+ \to \pi^+ \pi^0 (\gamma)$, searching for the decay of the $\pi^0$ to invisible particles. No signal is observed in excess of the expected background fluctuations. An upper limit of $4.4 \times 10^{-9}$ is set on the branching ratio at 90% confidence level, improving on previous results by a factor of 60. This result can also be interpreted as a model-independent upper limit on the branching ratio for the decay $K^+ \to \pi^+ X$ where $X$ is a particle escaping detection with mass in the range $0.110–0.155$ GeV/$c^2$ and rest lifetime greater than 100 ps. Model- dependent upper limits are obtained assuming $X$ to be an axion-like particle with dominant fermion couplings or a dark scalar mixing with the Standard Model Higgs.The NA62 experiment at the CERN SPS reports a study of a sample of $4 \times10^{9}$ tagged $\pi^0$ mesons from $K^+ \to \pi^+ \pi^0 (\gamma)$, searching for the decay of the $\pi^0$ to invisible particles. No signal is observed in excess of the expected background fluctuations. An upper limit of $4.4 \times10^{-9}$ is set on the branching ratio at 90% confidence level, improving on previous results by a factor of 60. This result can also be interpreted as a model-independent upper limit on the branching ratio for the decay $K^+ \to \pi^+ X$, where $X$ is a particle escaping detection with mass in the range 0.110-0.155 GeV$/c^2$ and rest lifetime greater than 100 ps. Model-dependent upper limits are obtained assuming $X$ to be an axion-like particle with dominant fermion couplings or a dark scalar mixing with the Standard Model Higgs boson

Searches for lepton number violating K+→π−(π0)e+e+K^+\to\pi^-(\pi^0)e^+e^+ decays

Searches for lepton number violating $K^+\to\pi^-e^+e^+$ and $K^+\to\pi^-\pi^0e^+e^+$ decays have been performed using the complete dataset collected by the NA62 experiment at CERN in 2016-2018. Upper limits of $5.3\times 10^{-11}$ and $8.5\times 10^{-10}$ are obtained on the decay branching fractions at 90% confidence level. The former result improves the limit by a factor of four over the previous best limit, while the latter result represents the first limit on the $K^+\to\pi^-\pi^0e^+e^+$ decay rate.Searches for lepton number violating K+→π−e+e+ and K+→π−π0e+e+ decays have been performed using the complete dataset collected by the NA62 experiment at CERN in 2016–2018. Upper limits of 5.3×10−11 and 8.5×10−10 are obtained on the decay branching fractions at 90% confidence level. The former result improves by a factor of four over the previous best limit, while the latter result represents the first limit on the K+→π−π0e+e+ decay rate.Searches for lepton number violating $K^+\to\pi^-e^+e^+$ and $K^+\to\pi^-\pi^0e^+e^+$ decays have been performed using the complete dataset collected by the NA62 experiment at CERN in 2016-2018. Upper limits of $5.3\times 10^{-11}$ and $8.5\times 10^{-10}$ are obtained on the decay branching fractions at 90% confidence level. The former result improves by a factor of four over the previous best limit, while the latter result represents the first limit on the $K^+\to\pi^-\pi^0e^+e^+$ decay rate

Search for K+K^+ decays to a muon and invisible particles

The NA62 experiment at CERN reports searches for $K^+\to\mu^+N$ and $K^+\to\mu^+\nu X$ decays, where $N$ and $X$ are massive invisible particles, using the 2016-2018 data set. The $N$ particle is assumed to be a heavy neutral lepton, and the results are expressed as upper limits of ${\cal O}(10^{-8})$ of the neutrino mixing parameter $|U_{\mu4}|^2$ for $N$ masses in the range 200-384 MeV/$c^2$ and lifetime exceeding 50 ns. The $X$ particle is considered a scalar or vector hidden sector mediator decaying to an invisible final state, and upper limits of the decay branching fraction for $X$ masses in the range 10-370 MeV/$c^2$ are reported for the first time, ranging from ${\cal O}(10^{-5})$ to ${\cal O}(10^{-7})$. An improved upper limit of $1.0\times 10^{-6}$ is established at 90% CL on the $K^+\to\mu^+\nu\nu\bar\nu$ branching fraction.The NA62 experiment at CERN reports searches for K+→μ+N and K+→μ+νX decays, where N and X are massive invisible particles, using the 2016–2018 data set. The N particle is assumed to be a heavy neutral lepton, and the results are expressed as upper limits of O(10−8) of the neutrino mixing parameter |Uμ4|2 for N masses in the range 200–384 MeV/ c2 and lifetime exceeding 50 ns. The X particle is considered a scalar or vector hidden sector mediator decaying to an invisible final state, and upper limits of the decay branching fraction for X masses in the range 10–370 MeV/ c2 are reported for the first time, ranging from O(10−5) to O(10−7) . An improved upper limit of 1.0×10−6 is established at 90% CL on the K+→μ+ννν¯ branching fraction.The NA62 experiment at CERN reports searches for $K^+\to\mu^+N$ and $K^+\to\mu^+\nu X$ decays, where $N$ and $X$ are massive invisible particles, using the 2016-2018 data set. The $N$ particle is assumed to be a heavy neutral lepton, and the results are expressed as upper limits of ${\cal O}(10^{-8})$ of the neutrino mixing parameter $|U_{\mu4}|^2$ for $N$ masses in the range 200-384 MeV/$c^2$ and lifetime exceeding 50 ns. The $X$ particle is considered a scalar or vector hidden sector mediator decaying to an invisible final state, and upper limits of the decay branching fraction for $X$ masses in the range 10-370 MeV/$c^2$ are reported for the first time, ranging from ${\cal O}(10^{-5})$ to ${\cal O}(10^{-7})$. An improved upper limit of $1.0\times 10^{-6}$ is established at 90% CL on the $K^+\to\mu^+\nu\nu\bar\nu$ branching fraction