AIoTES: Setting the principles for semantic interoperable and modern IoT-enabled reference architecture for Active and Healthy Ageing ecosystems

[EN] The average life expectancy of the world's population is increasing and the healthcare systems sooner than later will be compromised by its reduced capacity and its highly economic cost; in addition, the age distribution of the population is leading towards the older spectrum. This trend will lead to immeasurable and unexpected economic problems and social changes. In order to face up this challenge and complex economic and social problem, it is necessary to rely on the appropriate digital tools and technological infrastructures for ensuring that the elderly are properly cared in their everyday living environments and they can live independently for longer. This article presents ACTIVAGE IoT Ecosystem Suite (AIoTES), a concrete reference architecture and its implementation process that addresses these issues and that was designed within the first European Large Scale Pilot, ACTIVAGE, a H2020 funded project by the European Commission with the objective of creating sustainable ecosystems for Active and Healthy Ageing (AHA) based on Internet of Things and big data technologies. AIoTES offers platform level semantic interoperability, with security and privacy, as well as Big Data and Ecosystem tools. AIoTES enables and promotes the creation, exchange and adoption of crossplatform services and applications for AHA. The number of existing AHA services and solutions are quite large, especially when state-of-the-art technology is introduced, however a concrete architecture such as AIoTES gains more importance and relevance by providing a vision for establishing a complete ecosystem, that looks for supporting a larger variety of AHA services, rather than claiming to be a unique solution for all the AHA domain problems. AIoTES has been successfully validated by testing all of its components, individually, integrated, and in real-world environments with 4345 direct users. Each validation is contextualized in 11 Deployment Sites (DS) with 13 Validation Scenarios covering the heterogeneity of the AHA-IoT needs. These results also show a clear path for improvement, as well as the importance for standardization efforts in the ever-evolving AHA-IoT domain.We thank to all the people who have participated in the development and validation of AIoTES. This work has been developed under the framework of the ACTIVAGE project. The project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 732679.Valero-López, CI.; Medrano-Gil, A.; González-Usach, R.; Julián-Seguí, M.; Fico, G.; Arredondo, MT.; Stavropoulos, TG.... (2021). AIoTES: Setting the principles for semantic interoperable and modern IoT-enabled reference architecture for Active and Healthy Ageing ecosystems. Computer Communications. 177:96-111. https://doi.org/10.1016/j.comcom.2021.06.0109611117

Neuromarketing Applied to Education. Analysis of face-to-face versus online teaching

[EN] The use of new technologies applied to e-learning has created a few issues related to the attention, as well as the improvement (or the lack) of learning. Thanks to the knowledge and technologies applied in neuromarketing, it has been proven that the levels of attention and commitment to learning, as well as the emotional intensity felt, are greater in a face-to-face classroom compared to a deferred broadcast of a class. Therefore, all this reconsiders a new field of study where distance education can be as effective as face-to-face education.[ES] El uso de las nuevas tecnologías aplicadas a la educación a distancia ha generado una serie de interrogantes respecto a la atención, así como el mejoramiento o no del aprendizaje. Gracias a los conocimientos y tecnologías aplicados en neuromarketing, se ha comprobado que los niveles de atención y compromiso con el aprendizaje, así como la intensidad emocional sentida, son mayores en un aula presencial frente a una retransmisión de una clase en diferido. Por lo que todo esto replantea un nuevo campo de estudio donde la educación a distancia pueda ser tan efectiva como la presencial.Bellido García, I.; Lomello, M.; Serrano Agudelo, D.; Olarte Valencia, MS.; Pérez Micharet, P.; Larios De Medrano Gutiérrez, A.; Gil Escobedo, J.... (2022). Neuromarketing Aplicado a la Educación. Análisis de la enseñanza presencial versus la enseñanza online. Editorial Universitat Politècnica de València. 1359-1373. https://doi.org/10.4995/INRED2022.2022.159171359137

BIOVID: Micro espacios audiovisuales sobre biodiversidad

Se han realizado, editado y publicado microespacios de video alojados en la web www.ucm.es/segbiodiversidad/videos sobre aspectos relacionados con la biodiversidad, ecología y metodologías de seguimiento de aves, murciélagos, artrópodos y flora del campus de la Universidad Complutense de Madrid

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Gestión del conocimiento. Perspectiva multidisciplinaria. Volumen 7

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, volumen 7, de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro es una publicación internacional, seriada, continua, arbitrada de acceso abierto a todas las áreas del conocimiento, que cuenta con el esfuerzo de investigadores de varios países del mundo, orientada a contribuir con procesos de gestión del conocimiento científico, tecnológico y humanístico que consoliden la transformación del conocimiento en diferentes escenarios, tanto organizacionales como universitarios, para el desarrollo de habilidades cognitivas del quehacer diario. La gestión del conocimiento es un camino para consolidar una plataforma en las empresas públicas o privadas, entidades educativas, organizaciones no gubernamentales, ya sea generando políticas para todas las jerarquías o un modelo de gestión para la administración, donde es fundamental articular el conocimiento, los trabajadores, directivos, el espacio de trabajo, hacia la creación de ambientes propicios para el desarrollo integral de las instituciones

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

PhDAY 2020 -FOO (Facultad de Óptica y Optometría)

Por cuarto año consecutivo los doctorandos de la Facultad de Óptica y Optometría de la Universidad Complutense de Madrid cuentan con un congreso propio organizado por y para ellos, el 4º PhDAY- FOO. Se trata de un congreso gratuito abierto en la que estos jóvenes científicos podrán presentar sus investigaciones al resto de sus compañeros predoctorales y a toda la comunidad universitaria que quiera disfrutar de este evento. Apunta en tu agenda: el 15 de octubre de 2020. En esta ocasión será un Congreso On-line para evitar que la incertidumbre asociada a la pandemia Covid-19 pudiera condicionar su celebración

Development methodology for semantic and distributed systems, with emphasis in Ambient Assisted Living Domain

Semantic technologies are used to share data, link data, and perform high level abstraction and reasoning over data. Distributed computer systems take advantage of networks to split the computing, storage, sensing, and networking workloads over di_erent nodes. Semantic and Distributed systems are systems which combine both paradigms, enabling ubiquitous computing and semantic interoperability between heterogeneous components. Ambient Assisted Living (AAL) is a technological paradigm where the user becomes the centre of the system, and the system is the environment the user lives in. AAL not only de_nes heterogeneous environments, services and technologies, it is also must address the complete spectrum of possible users. One particular area AAL is used extensively is in Active and Healthy Ageing, or the application of technologies to facilitate the ageing process of individuals, their relatives, as well as positively impacting society as a whole. In this context a model for AAL oriented Semantic and Distributed systems is proposed, examining 9 simultaneous perspectives for the analysis and design of said systems considering all complex scenarios they may entail. In order to validate Semantic and Distributed Systems, from the multiple perspectives of the di_erent stakeholders involved in AAL, as well as itemizing concrete technological values of the system a value oriented multi-dimension evaluation methodology is proposed. This methodology is used to determine and analyse the required values from AAL semantic and distributed platforms. A cocreation methodology is proposed for the overall development of semantic and distributed systems, combining both the proposed model and methodology. The model validated by applying it to 3 distinct and unique AAL related concept projects, showing the extents the model could be used for. The AAL platform values are evaluated and analysed thoroughly through the participation of up to 60 individuals, covering all involved stakeholders. The model, and AAL platform values, are analysed to produce a set of improvements over existing AAL platform (universAAL IoT), this process is used as validation of the _tness of the proposed model and methodology; as well as the validation of the AAL platform itself. The Cocreation Methodology is reviewed for its application of 2 large scale projects, analysing the concrete experiences, results, and lessons learned in each one. ----------RESUMEN---------- Las tecnologías semánticas se utilizan para compartir datos, vincular datos y realizar abstracciones y razonamientos de alto nivel sobre los mismos datos. Los sistemas informáticos distribuidos aprovechan las redes de computadoras para dividir las cargas de trabajo de computación, almacenamiento, detección y red entre diferentes nodos. Los sistemas semánticos y distribuidos son sistemas que combinan ambos paradigmas, permitiendo la computación ubicua y la interoperabilidad semántica entre componentes heterogéneos. Ambient Assisted Living (AAL) es un paradigma tecnológico en el que el usuario se convierte en el centro del sistema, y el sistema es el entorno en el que vive el usuario. AAL no solo define entornos, servicios y tecnologías heterogéneas, sino que también debe abordar el espectro completo de posibles usuarios. Un área particular que AAL se usa ampliamente es el Envejecimiento Activo y Saludable (AHA), o la aplicación de tecnologías para facilitar el proceso de envejecimiento con salud y bienestar de las personas, sus familiares produciendo un impacto positivo en la sociedad en su conjunto. En este contexto, se propone un modelo para sistemas semánticos y distribuidos orientados a AAL, que examinan 9 perspectivas simultáneas para el análisis y diseño de dichos sistemas considerando todos los escenarios complejos que puedan originarse. Para validar los sistemas semánticos y distribuidos desde las múltiples perspectivas de los diferentes actores involucrados en AAL, así como para detallar los valores tecnológicos concretos del sistema, se propone una metodología de evaluación multidimensional orientada al valor. Esta metodología se utiliza para determinar y analizar los valores requeridos de las plataformas semánticas y distribuidas en AAL. Se propone una metodología de cocreación para el desarrollo general de sistemas semánticos y distribuidos, que combina el modelo propuesto y la metodología propuesta. El modelo se validó aplicándolo a tres proyectos conceptuales relacionados con AAL, distintos y únicos, que muestran ejemplos de la extensión de aplicación del modelo. Los valores de la plataforma AAL se evalúan y analizan exhaustivamente a través de la participación de hasta 60 personas, que cubren a todos los roles involucrados en el AAL. El modelo y los valores de la plataforma AAL se analizan para producir un conjunto de mejoras sobre una plataforma AAL existente (universAAL IoT), este proceso se utiliza como validación de la idoneidad del modelo y la metodología propuestos; así como la validación de la plataforma AAL en sí. La Metodología de Creación se revisa para su aplicación en dos proyectos de despliegue a gran escala, analizando las experiencias concretas, los resultados y las lecciones aprendidas en cada uno