Monitoring and Implementation of Children's Rights

Effective Protection of Fundamental Rights in a pluralist worl

Mono-Energy Coronary Angiography with a Compact Synchrotron Source

X-ray coronary angiography is an invaluable tool for the diagnosis of coronary artery disease. However, the use of iodine-based contrast media can be contraindicated for patients who present with chronic renal insufficiency or with severe iodine allergy. These patients could benefit from a reduced contrast agent concentration, possibly achieved through application of a mono-energetic x-ray beam. While large-scale synchrotrons are impractical for daily clinical use, the technology of compact synchrotron sources strongly advanced during the last decade. Here we present a quantitative analysis of the benefits a compact synchrotron source can offer in coronary angiography. Simulated projection data from quasi-mono-energetic and conventional x-ray tube spectra is used for a CNR comparison. Results show that compact synchrotron spectra would allow for a significant reduction of contrast media. Experimentally, we demonstrate the feasibility of coronary angiography at the Munich Compact Light Source, the first commercial installation of a compact synchrotron source

Direct quantitative material decomposition employing grating-based X-ray phase-contrast CT

Abstract Dual-energy CT has opened up a new level of quantitative X-ray imaging for many diagnostic applications. The energy dependence of the X-ray attenuation is the key to quantitative material decomposition of the volume under investigation. This material decomposition allows the calculation of virtual native images in contrast enhanced angiography, virtual monoenergetic images for beam-hardening artifact reduction and quantitative material maps, among others. These visualizations have been proven beneficial for various diagnostic questions. Here, we demonstrate a new method of ‘virtual dual-energy CT’ employing grating-based phase-contrast for quantitative material decomposition. Analogue to the measurement at two different energies, the applied phase-contrast measurement approach yields dual information in form of a phase-shift and an attenuation image. Based on these two image channels, all known dual-energy applications can be demonstrated with our technique. While still in a preclinical state, the method features the important advantages of direct access to the electron density via the phase image, simultaneous availability of the conventional attenuation image at the full energy spectrum and therefore inherently registered image channels. The transfer of this signal extraction approach to phase-contrast data multiplies the diagnostic information gained within a single CT acquisition. The method is demonstrated with a phantom consisting of exemplary solid and fluid materials as well as a chicken heart with an iodine filled tube simulating a vessel. For this first demonstration all measurements have been conducted at a compact laser-undulator synchrotron X-ray source with a tunable X-ray energy and a narrow spectral bandwidth, to validate the quantitativeness of the processing approach

Towards a comprehensive legal aid system in Bangladesh: the need for early access to legal aid in criminal proceedings

The government-funded legal aid system in Bangladesh has been undergoing development. Bangladesh has guaranteed the right to legal assistance in different laws and particularly in the Legal Aid Services Act (LASA) with specific and greater detail. Moreover, it acceded to the International Covenant on Civil and Political Rights (ICCPR) in 2000. In this context, the purpose of this article is to examine the current practice of the country with respect to the granting of early access to legal aid in criminal proceedings in light of international human rights standards. The article indicates that the prevailing problem of arbitrary arrest and pre-trial detention of those who are living in poverty is a matter of grave concern in Bangladesh. The author, therefore, recommends a mechanism to ensure early access to legal aid in the government-operated legal aid framework, as a fundamental aspect of a comprehensive system, for the protection of the interests of those who have been arrested or detained prior to being interviewed and formally charged of a criminal offence