A combinatorial investigation of sputtered Ta-Al-C thin films

We describe a combinatorial experiment investigating the Ta–Al–C material system, conducted with the aim of determining why the tantalum-containing Mn + 1AXn phases have so far proved to be not amenable to thin-film synthesis. Samples were deposited onto (0001) Al2O3 wafers at 850 °C and characterized by X-ray diffraction wafer maps, scanning electron microscopy, and surface optical scattering. Elemental Ta, the binary phases TaC, Ta2C, and TaAl3, and the ternary phases Ta3Al2C and Ta5Al3C were identified. The morphology, phase composition and preferred orientation of the films deposited were found to be highly sensitive to the Ta fraction of the incident flux during deposition. No MAX phase material was observed, indicating that the Ta-containing MAX phases do not form under the deposition conditions investigated. Explanations associated with inadequate coverage of stochiometries, preferential sputtering, and thermodynamic instability have been ruled out. An explanation based on reduced surface diffusion of Ta during growth is proposed. A substantially higher substrate temperature during deposition is likely to be required to synthesize Ta-containing MAX phases

Exact solution at integrable coupling of a model for the Josephson effect between small metallic grains

A model is introduced for two reduced BCS systems which are coupled through the transfer of Cooper pairs between the systems. The model may thus be used in the analysis of the Josephson effect arising from pair tunneling between two strongly coupled small metallic grains. At a particular coupling strength the model is integrable and explicit results are derived for the energy spectrum, conserved operators, integrals of motion, and wave function scalar products. It is also shown that form factors can be obtained for the calculation of correlation functions. Further, a connection with perturbed conformal field theory is made.Comment: 12 pages, latex, no figure

Propulsion System Modeling and Takeoff Distance Calculations for a Powered-Lift Aircraft with Circulation-Control Wing Aerodynamics

The computation of takeoff distance for powered-lift aircraft is complicated because of the coupling of aerodynamic performance (lift, drag and moment coefficients) with forward speed. Cal Poly has developed an analysis procedure to capture this coupling, and the development of this procedure is continuing. In the past year, Cal Poly has completed a Phase I NRA contract from the NASA for the configuration development and modeling of CESTOL aircraft. The primary objective of this contract was to identify an aircraft configuration in enough detail to proceed into a Phase II contract to design and construct a large scale wind tunnel model followed by a wind tunnel test to measure both aerodynamic performance and noise. Four aircraft configurations have been developed, and all but one of the configurations use circulation control wing aerodynamics (CCW) to produce powered-lift aerodynamic effect for the wing. The aircraft configuration selected for the Phase II contract makes extensive use of CCW to develop high lift aerodynamics for takeoff and initial climb and again for final descent and landing. An additional goal for the Phase I project was the CFD modeling of the aerodynamics of a CESTOL aircraft, and to use the CFD results to develop a new aerodynamic meta-model. In addition, a meta-model for propulsion performance was to be developed and the two meta-models were to be integrated into an upgraded takeoff code written in MATLAB. These models all combined were to demonstrate an up-graded version of the Cal Poly takeoff performance procedure. However, at present, the aerodynamics meta-model is not yet complete and work will continue on into Phase II. Thus, no specific takeoff performance is demonstrated in this paper. However, in this paper details of the aircraft configurations are presented, the options available to proceed high pressure air to the wing slots to produce CCW aerodynamics are discussed, the propulsion metamodel is defined, the analysis procedure for the aerodynamics meta-model is discussed and the up-graded takeoff program is discussed

Solvable models of Bose-Einstein condensates: a new algebraic Bethe ansatz scheme

A new algebraic Bethe ansatz scheme is proposed to diagonalise classes of integrable models relevant to the description of Bose-Einstein condensates in dilute alkali gases. This is achieved by introducing the notion of Z-graded representations of the Yang-Baxter algebra.Comment: 14 pages, latex, no figure

Integrability and exact spectrum of a pairing model for nucleons

A pairing model for nucleons, introduced by Richardson in 1966, which describes proton-neutron pairing as well as proton-proton and neutron-neutron pairing, is re-examined in the context of the Quantum Inverse Scattering Method. Specifically, this shows that the model is integrable by enabling the explicit construction of the conserved operators. We determine the eigenvalues of these operators in terms of the Bethe ansatz, which in turn leads to an expression for the energy eigenvalues of the Hamiltonian.Comment: 14 pages, latex, no figure

Ladder operator for the one-dimensional Hubbard model

The one-dimensional Hubbard model is integrable in the sense that it has an infinite family of conserved currents. We explicitly construct a ladder operator which can be used to iteratively generate all of the conserved current operators. This construction is different from that used for Lorentz invariant systems such as the Heisenberg model. The Hubbard model is not Lorentz invariant, due to the separation of spin and charge excitations. The ladder operator is obtained by a very general formalism which is applicable to any model that can be derived from a solution of the Yang-Baxter equation.Comment: 4 pages, no figures, revtex; final version to appear in Phys. Rev. Let

Superconducting correlations in metallic nanoparticles: exact solution of the BCS model by the algebraic Bethe ansatz

Superconducting pairing of electrons in nanoscale metallic particles with discrete energy levels and a fixed number of electrons is described by the reduced BCS model Hamiltonian. We show that this model is integrable by the algebraic Bethe ansatz. The eigenstates, spectrum, conserved operators, integrals of motion, and norms of wave functions are obtained. Furthermore, the quantum inverse problem is solved, meaning that form factors and correlation functions can be explicitly evaluated. Closed form expressions are given for the form factors that describe superconducting pairing.Comment: revised version, 5 pages, revtex, no figure

Algebraic Bethe ansatz method for the exact calculation of energy spectra and form factors: applications to models of Bose-Einstein condensates and metallic nanograins

In this review we demonstrate how the algebraic Bethe ansatz is used for the calculation of the energy spectra and form factors (operator matrix elements in the basis of Hamiltonian eigenstates) in exactly solvable quantum systems. As examples we apply the theory to several models of current interest in the study of Bose-Einstein condensates, which have been successfully created using ultracold dilute atomic gases. The first model we introduce describes Josephson tunneling between two coupled Bose-Einstein condensates. It can be used not only for the study of tunneling between condensates of atomic gases, but for solid state Josephson junctions and coupled Cooper pair boxes. The theory is also applicable to models of atomic-molecular Bose-Einstein condensates, with two examples given and analysed. Additionally, these same two models are relevant to studies in quantum optics. Finally, we discuss the model of Bardeen, Cooper and Schrieffer in this framework, which is appropriate for systems of ultracold fermionic atomic gases, as well as being applicable for the description of superconducting correlations in metallic grains with nanoscale dimensions. In applying all of the above models to physical situations, the need for an exact analysis of small scale systems is established due to large quantum fluctuations which render mean-field approaches inaccurate.Comment: 49 pages, 1 figure, invited review for J. Phys. A., published version available at http://stacks.iop.org/JPhysA/36/R6

Synthesis and activity of a novel Autotaxin inhibitor-Icodextrin conjugate

© Copyright 2018 American Chemical Society. Autotaxin is an extracellular phospholipase D that catalyses the hydrolysis of lysophosphatidyl choline (LPC) to generate the bioactive lipid lysophosphatidic acid (LPA). Autotaxin has been implicated in many pathological processes relevant to cancer. Intraperitoneal administration of an autotaxin inhibitor may benefit patients with ovarian cancer, however low molecular mass compounds are known to be rapidly cleared from the peritoneal cavity. Icodextrin is a polymer that is already in clinical use because it is slowly eliminated from the peritoneal cavity. Herein we report conjugation of the autotaxin inhibitor HA-155 to icodextrin. The conjugate inhibits autotaxin activity (IC50 = 0.86 ± 0.13 μg mL-1) and reduces cell migration. Conjugation of the inhibitor increased its solubility, decreased its membrane permeability and improved its intraperitoneal retention in mice. These observations demonstrate the first application of icodextrin as a covalently-bonded drug delivery platform with potential use in the treatment of ovarian cancer

A Systematic Mapping Approach of 16q12.2/FTO and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study

Genetic variants in intron 1 of the fat mass- and obesity-associated (FTO) gene have been consistently associated with body mass index (BMI) in Europeans. However, follow-up studies in African Americans (AA) have shown no support for some of the most consistently BMI-associated FTO index single nucleotide polymorphisms (SNPs). This is most likely explained by different race-specific linkage disequilibrium (LD) patterns and lower correlation overall in AA, which provides the opportunity to fine-map this region and narrow in on the functional variant. To comprehensively explore the 16q12.2/FTO locus and to search for second independent signals in the broader region, we fine-mapped a 646-kb region, encompassing the large FTO gene and the flanking gene RPGRIP1L by investigating a total of 3,756 variants (1,529 genotyped and 2,227 imputed variants) in 20,488 AAs across five studies. We observed associations between BMI and variants in the known FTO intron 1 locus: the SNP with the most significant p-value, rs56137030 (8.3×10-6) had not been highlighted in previous studies. While rs56137030was correlated at r2>0.5 with 103 SNPs in Europeans (including the GWAS index SNPs), this number was reduced to 28 SNPs in AA. Among rs56137030 and the 28 correlated SNPs, six were located within candidate intronic regulatory elements, including rs1421085, for which we predicted allele-specific binding affinity for the transcription factor CUX1, which has recently been implicated in the regulation of FTO. We did not find strong evidence for a second independent signal in the broader region. In summary, this large fine-mapping study in AA has substantially reduced the number of common alleles that are likely to be functional candidates of the known FTO locus. Importantly our study demonstrated that comprehensive fine-mapping in AA provides a powerful approach to narrow in on the functional candidate(s) underlying the initial GWAS findings in European populations