Alien Registration- Mckenney, Laura L. (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/23349/thumbnail.jp

Characterization, deployment, and in-flight performance of the BLAST-TNG cryogenic receiver

The Next Generation Balloon-borne Large Aperture Submillimeter Telescope (BLAST-TNG) is a submillimeter polarimeter designed to map interstellar dust and galactic foregrounds at 250, 350, and 500 microns during a 24-day Antarctic flight. The BLAST-TNG detector arrays are comprised of 918, 469, and 272 MKID pixels, respectively. The pixels are formed from two orthogonally oriented, crossed, linear-polarization sensitive MKID antennae. The arrays are cooled to sub 300mK temperatures and stabilized via a closed cycle $^3$He sorption fridge in combination with a $^4$He vacuum pot. The detectors are read out through a combination of the second-generation Reconfigurable Open Architecture Computing Hardware (ROACH2) and custom RF electronics designed for BLAST-TNG. The firmware and software designed to readout and characterize these detectors was built from scratch by the BLAST team around these detectors, and has been adapted for use by other MKID instruments such as TolTEC and OLIMPO. We present an overview of these systems as well as in-depth methodology of the ground-based characterization and the measured in-flight performance.Comment: Presented at SPIE Millimeter, Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy X, December 13-18, 202

Diagnosis and management of Cornelia de Lange syndrome:first international consensus statement

Cornelia de Lange syndrome (CdLS) is an archetypical genetic syndrome that is characterized by intellectual disability, well-defined facial features, upper limb anomalies and atypical growth, among numerous other signs and symptoms. It is caused by variants in any one of seven genes, all of which have a structural or regulatory function in the cohesin complex. Although recent advances in next-generation sequencing have improved molecular diagnostics, marked heterogeneity exists in clinical and molecular diagnostic approaches and care practices worldwide. Here, we outline a series of recommendations that document the consensus of a group of international experts on clinical diagnostic criteria, both for classic CdLS and non-classic CdLS phenotypes, molecular investigations, long-term management and care planning

Alien Registration- Mckenney, Laura L. (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/23349/thumbnail.jp

Alien Registration- Mckenney, Laura L. (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/23349/thumbnail.jp

Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline

This report summarizes the identification and synthesis of novel LpxC inhibitors aided by computational methods that leveraged numerous crystal structures. This effort led to the identification of oxazolidinone and isoxazoline inhibitors with potent in vitro activity against P. aeruginosa and other Gram-negative bacteria. Representative compound 13f demonstrated efficacy against P. aeruginosa in a mouse neutropenic thigh infection model. The antibacterial activity against K. pneumoniae could be potentiated by Gram-positive antibiotics rifampicin (RIF) and vancomycin (VAN) in both in vitro and in vivo models