3,610 research outputs found
Beyond Diagnosis: Evolving Prostate Biopsy in the Era of Focal Therapy
Despite decades of use as the âgold standardâ in the detection of prostate cancer, the optimal biopsy regimen is still not universally agreed upon. While important aspects such as the need for laterally placed biopsies and the importance of apical cancer are known, repeated studies have shown significant patients with cancer on subsequent biopsy when the original biopsy was negative and an ongoing suspicion of cancer remained. Attempts to maximise the effectiveness of repeat biopsies have given rise to the alternate approaches of saturation biopsy and the transperineal approach. Recent interest in focal treatment of prostate cancer has further highlighted the need for accurate detection of prostate cancer, and in response, the introduction of transperineal template-guided biopsy. While the saturation biopsy approach and the transperineal template approach increase the detection rate of cancer in men with a previous negative biopsy and appear to have acceptable morbidity, there is a lack of clinical trials evaluating the different biopsy strategies. This paper reviews the evolution of prostatic biopsy and current controversies
A Coherent Study of Emission Lines from Broad-Band Photometry: Specific Star-Formation Rates and [OIII]/H{\beta} Ratio at 3 < z < 6
We measure the H{\alpha} and [OIII] emission line properties as well as
specific star-formation rates (sSFR) of spectroscopically confirmed 3<z<6
galaxies in COSMOS from their observed colors vs. redshift evolution. Our model
describes consistently the ensemble of galaxies including intrinsic properties
(age, metallicity, star-formation history), dust-attenuation, and optical
emission lines. We forward-model the measured H{\alpha} equivalent-widths (EW)
to obtain the sSFR out to z~6 without stellar mass fitting. We find a strongly
increasing rest-frame H{\alpha} EW that is flattening off above z~2.5 with
average EWs of 300-600A at z~6. The sSFR is increasing proportional to
(1+z)^2.4 at z<2.2 and (1+z)^1.5 at higher redshifts, indicative of a fast mass
build-up in high-z galaxies within e-folding times of 100-200Myr at z~6. The
redshift evolution at z>3 cannot be fully explained in a picture of cold
accretion driven growth. We find a progressively increasing
[OIII]{\lambda}5007/H{\beta} ratio out to z~6, consistent with the ratios in
local galaxies selected by increasing H{\alpha} EW (i.e., sSFR). This
demonstrates the potential of using "local high-z analogs" to investigate the
spectroscopic properties and relations of galaxies in the re-ionization epoch.Comment: 18 pages, 11 figures, 3 table
Rest-UV Absorption Lines as Metallicity Estimator: the Metal Content of Star-Forming Galaxies at z~5
We measure a relation between the depth of four prominent rest-UV absorption
complexes and metallicity for local galaxies and verify it up to z~3. We then
apply this relation to a sample of 224 galaxies at 3.5 = 4.8) in
COSMOS, for which unique UV spectra from DEIMOS and accurate stellar masses
from SPLASH are available. The average galaxy population at z~5 and log(M/Msun)
> 9 is characterized by 0.3-0.4 dex (in units of 12+log(O/H)) lower
metallicities than at z~2, but comparable to z~3.5. We find galaxies with
weak/no Ly-alpha emission to have metallicities comparable to z~2 galaxies and
therefore may represent an evolved sub-population of z~5 galaxies. We find a
correlation between metallicity and dust in good agreement with local galaxies
and an inverse trend between metallicity and star-formation rate (SFR)
consistent with observations at z~2. The relation between stellar mass and
metallicity (MZ relation) is similar to z~3.5, however, there are indications
of it being slightly shallower, in particular for the young, Ly-alpha emitting
galaxies. We show that, within a "bathtub" approach, a shallower MZ relation is
expected in the case of a fast (exponential) build-up of stellar mass with an
e-folding time of 100-200 Myr. Due to this fast evolution, the process of dust
production and metal enrichment as a function of mass could be more stochastic
in the first billion years of galaxy formation compared to later times.Comment: 20 pages, 13 figures, 4 tables; Submitted to Ap
A robust morphological classification of high-redshift galaxies using support vector machines on seeing limited images. II. Quantifying morphological k-correction in the COSMOS field at 1<z<2: Ks band vs. I band
We quantify the effects of \emph{morphological k-correction} at by
comparing morphologies measured in the K and I-bands in the COSMOS area.
Ks-band data have indeed the advantage of probing old stellar populations for
, enabling a determination of galaxy morphological types unaffected by
recent star formation. In paper I we presented a new non-parametric method to
quantify morphologies of galaxies on seeing limited images based on support
vector machines. Here we use this method to classify
selected galaxies in the COSMOS area observed with WIRCam at CFHT. The obtained
classification is used to investigate the redshift distributions and number
counts per morphological type up to and to compare to the results
obtained with HST/ACS in the I-band on the same objects from other works. We
associate to every galaxy with and a probability between 0 and
1 of being late-type or early-type. The classification is found to be reliable
up to . The mean probability is . It decreases with redshift
and with size, especially for the early-type population but remains above
. The classification is globally in good agreement with the one
obtained using HST/ACS for . Above , the I-band classification
tends to find less early-type galaxies than the Ks-band one by a factor
1.5 which might be a consequence of morphological k-correction effects.
We argue therefore that studies based on I-band HST/ACS classifications at
could be underestimating the elliptical population. [abridged]Comment: accepted for publication in A&A, updated with referee comments, 12
pages, 10 figure
A proto-cluster at z=2.45
We present the spectroscopic confirmation of a proto-cluster. Its
member galaxies lie within a radius of 1.4Mpc (physical) on the sky and within
km/s along the line of sight. We estimate an overdensity of
10, suggesting that the structure has made the turn-around but is not assembled
yet. Comparison to the Millennium simulation suggests that analogous structures
evolve into M/h type dark matter haloes by
qualifying the notion of "proto-cluster". The search for the complete census of
mock progenitor galaxies at of these massive mock clusters
reveals that they are widely spread over areas with a diameter of 3-20Mpc. This
suggests that the optical selection of such proto-clusters can result in a rich
diversity regarding their descendants. We also searched for signs of
environmental differentiation in this proto-cluster. Whilst we see a weak trend
for more massive and more quiescent galaxies in the proto-cluster, this is not
statistically significant.Comment: submitted to Ap
Dark energy constraints and correlations with systematics from CFHTLS weak lensing, SNLS supernovae Ia and WMAP5
We combine measurements of weak gravitational lensing from the CFHTLS-Wide
survey, supernovae Ia from CFHT SNLS and CMB anisotropies from WMAP5 to obtain
joint constraints on cosmological parameters, in particular, the dark energy
equation of state parameter w. We assess the influence of systematics in the
data on the results and look for possible correlations with cosmological
parameters.
We implement an MCMC algorithm to sample the parameter space of a flat CDM
model with a dark-energy component of constant w. Systematics in the data are
parametrised and included in the analysis. We determine the influence of
photometric calibration of SNIa data on cosmological results by calculating the
response of the distance modulus to photometric zero-point variations. The weak
lensing data set is tested for anomalous field-to-field variations and a
systematic shape measurement bias for high-z galaxies.
Ignoring photometric uncertainties for SNLS biases cosmological parameters by
at most 20% of the statistical errors, using supernovae only; the parameter
uncertainties are underestimated by 10%. The weak lensing field-to-field
variance pointings is 5%-15% higher than that predicted from N-body
simulations. We find no bias of the lensing signal at high redshift, within the
framework of a simple model. Assuming a systematic underestimation of the
lensing signal at high redshift, the normalisation sigma_8 increases by up to
8%. Combining all three probes we obtain -0.10<1+w<0.06 at 68% confidence
(-0.18<1+w<0.12 at 95%), including systematic errors. Systematics in the data
increase the error bars by up to 35%; the best-fit values change by less than
0.15sigma. [Abridged]Comment: 14 pages, 10 figures. Revised version, matches the one to be
published in A&A. Modifications have been made corresponding to the referee's
suggestions, including reordering of some section
The VIPERS Multi-Lambda Survey. I. UV and NIR Observations, multi-color catalogues and photometric redshifts
We present observations collected in the CFHTLS-VIPERS region in the
ultraviolet (UV) with the GALEX satellite (far and near UV channels) and the
near infrared with the CFHT/WIRCam camera (-band) over an area of 22 and
27 deg, respectively. The depth of the photometry was optimized to measure
the physical properties (e.g., SFR, stellar masses) of all the galaxies in the
VIPERS spectroscopic survey. The large volume explored by VIPERS will enable a
unique investigation of the relationship between the galaxy properties and
their environment (density field and cosmic web) at high redshift (0.5 < z <
1.2). In this paper, we present the observations, the data reductions and the
build-up of the multi-color catalogues. The CFHTLS-T0007 (gri-{\chi}^2) images
are used as reference to detect and measure the -band photometry, while
the T0007 u-selected sources are used as priors to perform the GALEX photometry
based on a dedicated software (EMphot). Our final sample reaches ~25
(at 5{\sigma}) and ~22 (at 3{\sigma}). The large spectroscopic sample
(~51,000 spectroscopic redshifts) allows us to highlight the robustness of our
star/galaxy separation, and the reliability of our photometric redshifts with a
typical accuracy 0.04 and a catastrophic failure rate {\eta} <
2% down to i~23. We present various tests on the band completeness and
photometric redshift accuracy by comparing with existing, overlapping deep
photometric catalogues. Finally, we discuss the BzK sample of passive and
active galaxies at high redshift and the evolution of galaxy morphology in the
(NUV-r) vs (r-K_s) diagram at low redshift (z < 0.25) thanks to the high image
quality of the CFHTLS. The images, catalogues and photometric redshifts for 1.5
million sources (down to 25 or 22) are released and
available at this URL: http://cesam.lam.fr/vipers-mls/Comment: 14 pages, 16 figures. Accepted for publication in A&A. Version to be
publishe
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