Unemployment Duration Before and After New Deal

A major active labour market policy - the New Deal for Young People (NDYP) - was introduced throughout the UK in 1998. We examine its effects on unemployment duration by estimating hazard functions for unemployment outflows before and after its introduction. We add value to existing evaluations in the following ways. First, we examine previously unused administrative data for Northern Ireland. Second, we examine NDYP effects at all unemployment durations. Third, we estimate separately by gender. Fourth, exits to employment, education and training and other benefits are identified separately. Since NDYP's introduction, young people are 25-50% less likely to experience year-long unemployment spells, with increased probabilities for all types of exit. NDYP is intended, however, to largely eradicate long term youth unemployment. We ask why this has not been the case in Northern Ireland.unemployment duration, new deal, hazard functions, young people

Agencies, ministers and civil servants in Britain

Huge variations exist in the relationships between politicians and agenciesin Britain, from very frequent contact in a politicised atmosphere to thecomplete absence of a direct relationship at all. The nature of therelationship appears to be determined less by agency status as such as bythe political sensitivity of particular policy issues. While politicians are notinvolved in the day-to-day running of most agencies, they have beenconcerned with operational matters in a small number of agencies. Whilemany agencies have no direct input into policy issues (and there are fewdirectly concerning them), in a limited number of cases the agency is themain source of policy advice because it is the repository of expertise, andin others the agency has the right to be consulted about any policyproposals affecting them, and to make policy proposals. The British NextSteps agency form, because of it relatively informal status, is relativelyadaptable to new purposes. Thus, agency status as such has provided littlehindrance to the new Labour government. Similarly, while agencies wereoriginally set up and largely operate with a vertical perspective on meetingtheir own targets, the form is adaptable to cross-organisational targets,though it cannot solve conflicting objectives or policies

Appreciative inquiry for stress management

Purpose: The purpose of this paper is to demonstrate the innovative application of an Appreciative Inquiry (AI) approach for the design and implementation of organizational stress management interventions, alongside a case study of the successful design and implementation of the approach. By utilizing the AI methodology to develop a “local stress theory” for the participating organization, the authors propose a model which can be utilized in other similar organizations. Design/methodology/approach: Stage 1: 35 participants completed up to ten daily logs by answering four positively framed questions regarding their working day. Stage 2: semi-structured interviews (n=13). The interview schedule was designed to further elaborate log findings, and begin looking into feasible organizational changes for improvement of stress. Stage 3: two focus groups (Stage 3, total 13 employees) verified interventions from logs and interviews and discuss how these can be implemented. Findings: The log phase identified two key themes for improvement: managerial/organizational support and communication. From these, interviews and focus groups led to workable proposals for simple but likely effective changes. The authors reported findings to management, emphasizing organizational change implementation, and these were subsequently implemented. Research limitations/implications: The study demonstrated the effectiveness of AI to identify and implement relatively simple but meaningful changes. The AI cycle was completed but allocating lengthy follow-up time for evaluation of outcomes was not possible, although initial responses were favorable. There are also issues of generalizability of the findings. Originality/value: This is the among first studies to utilize an AI approach for the design of stress management interventions

Diversity and environmental adaptation of phagocytic cell metabolism

Phagocytes are cells of the immune system that play important roles in phagocytosis, respiratory burst and degranulation-key components of innate immunity and response to infection. This diverse group of cells includes monocytes, macrophages, dendritic cells, neutrophils, eosinophils, and basophils-heterogeneous cell populations possessing cell and tissue-specific functions of which cellular metabolism comprises a critical underpinning. Core functions of phagocytic cells are diverse and sensitive to alterations in environmental- and tissue-specific nutrients and growth factors. As phagocytic cells adapt to these extracellular cues, cellular processes are altered and may contribute to pathogenesis. The considerable degree of functional heterogeneity among monocyte, neutrophil, and other phagocytic cell populations necessitates diverse metabolism. As we review our current understanding of metabolism in phagocytic cells, gaps are focused on to highlight the need for additional studies that hopefully enable improved cell-based strategies for counteracting cancer and other diseases

Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels

The importance of metabolism in macrophage function has been reported, but the in vivo relevance of the in vitro observations is still unclear. Here we show that macrophage metabolites are defined in a specific tissue context, and these metabolites are crucially linked to tissue-resident macrophage functions. We find the peritoneum to be rich in glutamate, a glutaminolysis-fuel that is exploited by peritoneal-resident macrophages to maintain respiratory burst during phagocytosis via enhancing mitochondrial complex-II metabolism. This niche-supported, inducible mitochondrial function is dependent on protein kinase C activity, and is required to fine-tune the cytokine responses that control inflammation. In addition, we find that peritoneal-resident macrophage mitochondria are recruited to phagosomes and produce mitochondrially derived reactive oxygen species, which are necessary for microbial killing. We propose that tissue-resident macrophages are metabolically poised in situ to protect and exploit their tissue-niche by utilising locally available fuels to implement specific metabolic programmes upon microbial sensing

Analysis of Binding of KIR3DS1*014 to HLA Suggests Distinct Evolutionary History of KIR3DS1

NK cell activity is regulated by the integration of positive and negative signals. One important source of these signals for human NK cells is the killer Ig-like receptor (KIR) family, which includes both members that transduce positive and those that generate negative signals. KIR3DL1 inhibits NK cell activity upon engagement by its ligand HLA-Bw4. The highly homologous KIR3DS1 is an activating receptor, which is implicated in the outcome of a variety of pathological situations. However, unlike KIR3DL1, direct binding of KIR3DS1+ cells to HLA has not been demonstrated. We analyzed four key amino acid differences between KIR3DL1*01502 and KIR3DS1*013 to determine their role in KIR binding to HLA. Single substitutions of these residues dramatically reduced binding by KIR3DL1. In the reciprocal experiment, we found that the rare KIR3DS1 allotype KIR3DS1*014 binds HLA-Bw4 even though it differs from KIR3DS1*013 at only one of these positions (position 138). This reactivity was unexpectedly dependent on residues at other variable positions, as HLA-Bw4 binding was lost in receptors with KIR3DL1-like residues at both positions 199 and 138. These data provide the first evidence, to our knowledge, for the direct binding of KIR3DS1+ cells to HLA-Bw4 and highlight the key role for position 138 in determining ligand specificity of KIR3DS1. They also reveal that KIR3DS1 reactivity and specificity is dictated by complex interactions between the residues in this region, suggesting a unique functional evolution of KIR3DS1 within the activating KIR family

Editorial: Metabolism Meets Function: Untangling the Cross-Talk Between Signaling and Metabolism

Tumor metabolism is a long established field in cancer biology, as the seminal findings of Otto Warburg date back to the 1920s. Since then, the discovery that oncogenes, besides promoting the Warburg effect, modulate anabolic pathways, has prompted scientists to re-evaluate the role that tumor metabolism plays in the neoplastic process. Today, metabolic reprogramming of neoplastic cells is considered a hallmark of cancer, with the discovery that flexibility in the acquisition of various cellular characteristics is supported by specific metabolic pathways. Clinical and pharmacological advances, for example the application of FDG-PET in the clinical setting (1) and the development of novel pharmacological strategies based on antimetabolites (2), provide further support and validation of the role of metabolism in cancer. Here, we present a collection of works with the aim of bringing together work from a variety of scientists across the field of tumor metabolism toward an understanding of how different metabolic pathways are activated in neoplastic and surrounding cells, the mechanisms linking altered metabolism to tumorigenesis and the potential for pharmacological applications

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis.

Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy. However, its role in macrophages remains elusive. We report that pharmacologic inhibition of GS skews M2-polarized macrophages toward the M1-like phenotype, characterized by reduced intracellular glutamine and increased succinate with enhanced glucose flux through glycolysis, which could be partly related to HIF1α activation. As a result of these metabolic changes and HIF1α accumulation, GS-inhibited macrophages display an increased capacity to induce T cell recruitment, reduced T cell suppressive potential, and an impaired ability to foster endothelial cell branching or cancer cell motility. Genetic deletion of macrophagic GS in tumor-bearing mice promotes tumor vessel pruning, vascular normalization, accumulation of cytotoxic T cells, and metastasis inhibition. These data identify GS activity as mediator of the proangiogenic, immunosuppressive, and pro-metastatic function of M2-like macrophages and highlight the possibility of targeting this enzyme in the treatment of cancer metastasis

Global changes in dryland vegetation dynamics (1988–2008) assessed by satellite remote sensing: comparing a new passive microwave vegetation density record with reflective greenness data

Drylands, covering nearly 30% of the global land surface, are characterized by high climate variability and sensitivity to land management. Here, two satellite-observed vegetation products were used to study the long-term (1988–2008) vegetation changes of global drylands: the widely used reflective-based Normalized Difference Vegetation Index (NDVI) and the recently developed passive-microwave-based Vegetation Optical Depth (VOD). The NDVI is sensitive to the chlorophyll concentrations in the canopy and the canopy cover fraction, while the VOD is sensitive to vegetation water content of both leafy and woody components. Therefore it can be expected that using both products helps to better characterize vegetation dynamics, particularly over regions with mixed herbaceous and woody vegetation. Linear regression analysis was performed between antecedent precipitation and observed NDVI and VOD independently to distinguish the contribution of climatic and non-climatic drivers in vegetation variations. Where possible, the contributions of fire, grazing, agriculture and CO₂ level to vegetation trends were assessed. The results suggest that NDVI is more sensitive to fluctuations in herbaceous vegetation, which primarily uses shallow soil water, whereas VOD is more sensitive to woody vegetation, which additionally can exploit deeper water stores. Globally, evidence is found for woody encroachment over drylands. In the arid drylands, woody encroachment appears to be at the expense of herbaceous vegetation and a global driver is interpreted. Trends in semi-arid drylands vary widely between regions, suggesting that local rather than global drivers caused most of the vegetation response. In savannas, besides precipitation, fire regime plays an important role in shaping trends. Our results demonstrate that NDVI and VOD provide complementary information and allow new insights into dryland vegetation dynamics