Measuring the Economic Impact of Recurrent Flooding on Workforce Productivity and Property

From the Executive Summary: This research draws upon expertise across multiple disciplines and fields. Leveraged are natural systems data and social-behavioral data. The high-level objective is to advance our understanding of how very recent recurrent flooding has impacted residents within the City of Portsmouth, and then forecast these impacts under projections of sea level rise. While this research draws upon data for the City of Portsmouth, the findings may be generalized to the broader Hampton Roads region

An optimal ALMA image of the Hubble Ultra Deep Field in the era of JWST: obscured star formation and the cosmic far-infrared background

We combine archival ALMA data targeting the Hubble Ultra Deep Field (HUDF) to produce the deepest currently attainable 1-mm maps of this key, extragalactic survey field. Combining all existing data in Band 6, our deepest map covers 4.2arcmin^2, with a beamsize of 1.49"x1.07" at an effective frequency of 243GHz (1.23mm). It reaches an rms of 4.6uJy/beam, with 1.5arcmin^2 below 9.0uJy/beam, an improvement of >5% over the best previously published map and 50% improvement in some regions. We also make a wider, but shallower map, covering 25.4arcmin^2. We detect 45 galaxies in the deep map down to 3.6sigma, including 10 more 1-mm sources than previously detected. 38 of these galaxies have a JWST ID from the JADES NIRCam imaging and the new sources are typically faint and red. A stacking analysis on the positions of ALMA-undetected JADES galaxies yields detections for z<4 and stellar masses from 10^(8.4) to 10^(10.4)Msun, extracting 10% of additional stacked signal from our map compared to previous analyses. Detected sources and stacking contribute (10.0+/-0.5)Jy/deg^2 of the cosmic infrared background (CIB) at 1.23mm. Although this is short of the (uncertain) background level of about 20Jy/deg^2, after taking into account intrinsic fluctuations in the CIB, our measurement is consistent with the background if the HUDF is a mild (~2sigma) negative fluctuation. This suggests that within the HUDF, JWST may have detected essentially all of the galaxies that contribute to the CIB. Our stacking analysis predicts that the field contains around 60 additional galaxies with 1.23mm flux densities averaging around 15uJy, and over 300 galaxies at the few uJy level. However, the contribution of these fainter more modestly-obscured objects to the background is small, and converging, as anticipated from the now well-established strong correlation between galaxy stellar mass and obscured star formation.Comment: Submitted to MNRA

Accounting for Cosmic Variance in Studies of Gravitationally-Lensed High-Redshift Galaxies in the Hubble Frontier Field Clusters

Strong gravitational lensing provides a powerful means for studying faint galaxies in the distant universe. By magnifying the apparent brightness of background sources, massive clusters enable the detection of galaxies fainter than the usual sensitivity limit for blank fields. However, this gain in effective sensitivity comes at the cost of a reduced survey volume and, in this {\it Letter}, we demonstrate there is an associated increase in the cosmic variance uncertainty. As an example, we show that the cosmic variance uncertainty of the high redshift population viewed through the Hubble Space Telescope Frontier Field cluster Abell 2744 increases from ~35% at redshift z~7 to >~65% at z~10. Previous studies of high redshift galaxies identified in the Frontier Fields have underestimated the cosmic variance uncertainty that will affect the ultimate constraints on both the faint end slope of the high-redshift luminosity function and the cosmic star formation rate density, key goals of the Frontier Field program.Comment: 5 pages, 3 figures. Version accepted by ApJ

Teleneurology service provided via tablet technology: 3-year outcomes and physician satisfaction

© James Cook University. Introduction: This study aimed to demonstrate that teleneurology consultations conducted via tablet technology are an efficient and cost-effective means of managing acute neurologic emergencies at community-based hospitals and that utilizing such technology yields high community physician satisfaction. Method: During a 39-month period, Vanderbilt University Medical Center in Tennessee USA, provided teleneurology services to 10 community-based hospitals that lacked adequate neurology coverage. Hospitalists at one community-based hospital were not comfortable treating any patient with a neurologic symptom, resulting in 100% of those patients being transferred. This facility now retains more than 60% of neurology patients. For less than US$1200, these hospitals were able to meet the only capital expenditure required to launch this service: the purchase of handheld tablet computers. Real-time teleneurology consultations were conducted via tablet using two-way video conferencing, radiologic image sharing, and medical record documentation. Community physicians were regularly surveyed to assess satisfaction. Results: From February 2014 to May 2017, 3626 teleneurology consultations were conducted. Community physicians, in partnership with neurologists, successfully managed 87% of patients at the community-based hospital. Only 13% of patients required transfer to another facility for a higher level of care. The most common diagnoses included stroke (34%), seizure (11%), and headache/migraine (6%). The average time for the neurologist to answer a request for consultation page and connect with the community physician was 10.6 minutes. Ninety-one percent of community physicians were satisfied or somewhat satisfied with the overall service. Conclusion: In the assessment of neurology patients, tablets are a more cost-effective alternative to traditional telehealth technologies. The devices promote efficiency in consultations through ease of use and low transfer rates, and survey results indicate community physician satisfaction

Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1

The functional assembly of the synaptic release machinery is well understood; however, how signalling factors modulate this process remains unknown. Recent studies suggest that Wnts play a role in presynaptic function. To examine the mechanisms involved, we investigated the interaction of release machinery proteins with Dishevelled-1 (Dvl1), a scaffold protein that determines the cellular locale of Wnt action. Here we show that Dvl1 directly interacts with Synaptotagmin-1 (Syt-1) and indirectly with the SNARE proteins SNAP25 and Syntaxin (Stx-1). Importantly, the interaction of Dvl1 with Syt-1, which is regulated by Wnts, modulates neurotransmitter release. Moreover, presynaptic terminals from Wnt signalling-deficient mice exhibit reduced release probability and are unable to sustain high-frequency release. Consistently, the readily releasable pool size and formation of SNARE complexes are reduced. Our studies demonstrate that Wnt signalling tunes neurotransmitter release and identify Syt-1 as a target for modulation by secreted signalling proteins.Fil: Ciani, Lorenza. University College London; Estados UnidosFil: Marzo, Aude. University College London; Estados UnidosFil: Boyle, Kieran. University College London; Estados UnidosFil: Stamatakou, Eleanna. University College London; Estados UnidosFil: Lopes, Douglas M.. University College London; Estados UnidosFil: Anane, Derek. University College London; Estados UnidosFil: McLeod, Faye. University College London; Estados UnidosFil: Rosso, Silvana Beatriz. University College London; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gibb, Alasdair. University College London; Estados UnidosFil: Salinas, Patricia C.. University College London; Estados Unido

Effect of consuming endophyte-infected fescue seed on transcript abundance in the mammary gland of lactating and dry cows, as assessed by RNA sequencing

Ergot alkaloids in endophyte-infected grasses inhibit prolactin secretion and reduce milk production in lactating cows. However, we previously showed that prepartum consumption of infected seed throughout the dry period did not inhibit subsequent milk production and prior exposure to bromocriptine (ergot peptide) actually increased production in the next lactation. To identify changes in the transcriptome and molecular pathways mediating the mammary gland's response to ergot alkaloids in the diet, RNA sequencing (RNA-seq) was performed on mammary tissues obtained from 22 multiparous Holstein cows exposed to 1 of 3 treatments. Starting at 90 ± 4 d prepartum, cows were fed endophyte-free fescue seed (control; CON), endophyte-free fescue seed plus 3×/wk subcutaneous injections of bromocriptine (BROMO; 0.1 mg/kg of BW), or endophyte-infected fescue seed (INF) as 10% of the diet. Cows were dried off 60 ± 2 d prepartum. Mammary biopsies from 4 (BROMO, INF) or 5 (CON) cows/treatment at each of the 3 phases were obtained: 7 d before dry off during the initial lactation (L1), mid-dry period (D), and 10 d postpartum (L2). Although tissue from the same cow was preferentially used at 3 phases (L1, D, L2), tissue from additional cows were used to as necessary to provide RNA of sufficient quality. Individual samples were used to generate individual RNA-seq libraries. Normalized reads of the RNA-seq data were organized into technical and biological replicates before processing with the RSEM software package. Each lactation phase was processed separately and genes that differed between any of 3 treatments were identified. A large proportion of genes differentially expressed in at least 1 treatment (n = 866) were found to be similarly expressed in BROMO and INF treatments, but differentially expressed from CON (n = 575, total for 3 phases). Of genes differentially expressed compared with CON, 104 genes were common to the L1 and L2 phases. Consistent with the production findings, networks most affected by treatments in L1 and L2 included lipid metabolism, small molecule biochemistry, and molecular transport, whereas networks related more to developmental and cellular functions and maintenance were evident during D phase. Similar patterns of expression in BROMO and INF during late and early lactation suggest involvement of similar cell signaling pathways or mechanisms of action for BROMO and INF and the importance of prolactin messaging pathways

A massive quiescent galaxy at redshift 4.658

A. C. Carnall thanks the Leverhulme Trust for their support via a Leverhulme Early Career Fellowship. R. J. McLure, J. S. Dunlop, D. J. McLeod, V. Wild, R. Begley, C. T. Donnan and M. L. Hamadouche acknowledge the support of the Science and Technology Facilities Council. F. Cullen acknowledges support from a UKRI Frontier Research Guarantee Grant (grant reference EP/X021025/1). A. Cimatti acknowledges support from the grant PRIN MIUR 2017 - 20173ML3WW 001.The extremely rapid assembly of the earliest galaxies during the first billion years of cosmic history is a major challenge for our understanding of galaxy formation physics (1; 2; 3; 4; 5). The advent of JWST has exacerbated this issue by confirming the existence of galaxies in significant numbers as early as the first few hundred million years (6; 7; 8). Perhaps even more surprisingly, in some galaxies, this initial highly efficient star formation rapidly shuts down, or quenches, giving rise to massive quiescent galaxies as little as 1.5 billion years after the Big Bang (9; 10), however, due to their faintness and red colour, it has proven extremely challenging to learn about these extreme quiescent galaxies, or to confirm whether any exist at earlier times. Here we report the spectroscopic confirmation of a massive quiescent galaxy, GS-9209, at redshift, z = 4.658, just 1.25 billion years after the Big Bang, using JWST NIRSpec. From these data we infer a stellar mass of M∗ = 3.8 ± 0.2 × 1010 M⊙, which formed over a ≃ 200 Myr period before this galaxy quenched its star formation activity at z=6.5+0.2−0.5, when the Universe was ≃ 800 million years old. This galaxy is both a likely descendent of the highest-redshift submillimetre galaxies and quasars, and a likely progenitor for the dense, ancient cores of the most massive local galaxies.PostprintPeer reviewe

Survey of the quality of experimental design, statistical analysis and reporting of research using animals

For scientific, ethical and economic reasons, experiments involving animals should be appropriately designed, correctly analysed and transparently reported. This increases the scientific validity of the results, and maximises the knowledge gained from each experiment. A minimum amount of relevant information must be included in scientific publications to ensure that the methods and results of a study can be reviewed, analysed and repeated. Omitting essential information can raise scientific and ethical concerns. We report the findings of a systematic survey of reporting, experimental design and statistical analysis in published biomedical research using laboratory animals. Medline and EMBASE were searched for studies reporting research on live rats, mice and non-human primates carried out in UK and US publicly funded research establishments. Detailed information was collected from 271 publications, about the objective or hypothesis of the study, the number, sex, age and/or weight of animals used, and experimental and statistical methods. Only 59% of the studies stated the hypothesis or objective of the study and the number and characteristics of the animals used. Appropriate and efficient experimental design is a critical component of high-quality science. Most of the papers surveyed did not use randomisation (87%) or blinding (86%), to reduce bias in animal selection and outcome assessment. Only 70% of the publications that used statistical methods described their methods and presented the results with a measure of error or variability. This survey has identified a number of issues that need to be addressed in order to improve experimental design and reporting in publications describing research using animals. Scientific publication is a powerful and important source of information; the authors of scientific publications therefore have a responsibility to describe their methods and results comprehensively, accurately and transparently, and peer reviewers and journal editors share the responsibility to ensure that published studies fulfil these criteria

HST Imaging of the Ionizing Radiation from a Star-forming Galaxy at z = 3.794

We report on the HST detection of the Lyman-continuum (LyC) radiation emitted by a galaxy at redshift z=3.794, dubbed Ion1 (Vanzella et al. 2012). The LyC from Ion1 is detected at rest-frame wavelength 820$\sim$890 \AA with HST WFC3/UVIS in the F410M band ($m_{410}=27.60\pm0.36$ magnitude (AB), peak SNR = 4.17 in a circular aperture with radius r = 0.12'') and at 700$\sim$830 \AA with the VLT/VIMOS in the U-band ($m_U = 27.84\pm0.19$ magnitude (AB), peak SNR = 6.7 with a r = 0.6'' aperture). A 20-hr VLT/VIMOS spectrum shows low- and high-ionization interstellar metal absorption lines, the P-Cygni profile of CIV and Ly$\alpha$ in absorption. The latter spectral feature differs from what observed in known LyC emitters, which show strong Ly$\alpha$ emission. An HST far-UV color map reveals that the LyC emission escapes from a region of the galaxy that is bluer than the rest, presumably because of lower dust obscuration. The F410M image shows that the centroid of the LyC emission is offset from the centroid of the non-ionizing UV emission by 0.12''$\pm$0.03'', corresponding to 0.85$\pm$0.21 kpc (physical), and that its morphology is likely moderately resolved. These morphological characteristics favor a scenario where the LyC photons produced by massive stars escape from low HI column-density "cavities" in the ISM, possibly carved by stellar winds and/or supernova. We also collect the VIMOS U-band images of a sample of 107 Lyman-break galaxies with spectroscopic redshifts at $3.40<z<3.95$, i.e. sampling the LyC, and stack them with inverse-variance weights. No LyC emission is detected in the stacked image, resulting in a 32.5 magnitude (AB) flux limit (1$\sigma$) and an upper limit of absolute LyC escape fraction $f_{esc}^{abs} < 0.63\%$. LyC emitters like Ion1 are very likely at the bright-end of the LyC luminosity function.Comment: 24 pages, 13 figures, accepted for publication in Ap