655 research outputs found
“The Future is Medieval”: Orality and Musical Borrowing in the Middle Ages and Online Remix Culture
This thesis re-situates sampling and the mashup in a broader tradition of musical borrowing and oral practice. Musical creators in the West borrowed throughout history; the variety and quantity of this borrowing remains dependent on the proprietary status of music. Copyright was first applied to music to protect printed scores, and is thus ill equipped to accommodate works that borrow recorded elements. Taking Ong’s concept of “secondary orality” as applied to hip hop by Tricia Rose, this thesis connects techniques of musical borrowing in the Middle Ages with those in the late-20th and 21st centuries through several close readings of representative works. By necessity, these orally circulating works are shared within a knowing community, one that understands the references and values continuing dialogue more than the contributions of individuals. Finally, this thesis makes recommendations for copyright reform, seeking to ensure that music with borrowed parts can continue to circulate in both commercial and non-commercial spheres
The Role of High-Dimensional Diffusive Search, Stabilization, and Frustration in Protein Folding
Proteins are polymeric molecules with many degrees of conformational freedom whose internal energetic interactions are typically screened to small distances. Therefore, in the high-dimensional conformation space of a protein, the energy landscape is locally relatively flat, in contrast to low-dimensional representations, where, because of the induced entropic contribution to the full free energy, it appears funnel-like. Proteins explore the conformation space by searching these flat subspaces to find a narrow energetic alley that we call a hypergutter and then explore the next, lower-dimensional, subspace. Such a framework provides an effective representation of the energy landscape and folding kinetics that does justice to the essential characteristic of high-dimensionality of the search-space. It also illuminates the important role of nonnative interactions in defining folding pathways. This principle is here illustrated using a coarse-grained model of a family of three-helix bundle proteins whose conformations, once secondary structure has formed, can be defined by six rotational degrees of freedom. Two folding mechanisms are possible, one of which involves an intermediate. The stabilization of intermediate subspaces (or states in low-dimensional projection) in protein folding can either speed up or slow down the folding rate depending on the amount of native and nonnative contacts made in those subspaces. The folding rate increases due to reduced-dimension pathways arising from the mere presence of intermediate states, but decreases if the contacts in the intermediate are very stable and introduce sizeable topological or energetic frustration that needs to be overcome. Remarkably, the hypergutter framework, although depending on just a few physically meaningful parameters, can reproduce all the types of experimentally observed curvature in chevron plots for realizations of this fold
Phase Separation in Binary Fluid Mixtures with Continuously Ramped Temperature
We consider the demixing of a binary fluid mixture, under gravity, which is
steadily driven into a two phase region by slowly ramping the temperature. We
assume, as a first approximation, that the system remains spatially isothermal,
and examine the interplay of two competing nonlinearities. One of these arises
because the supersaturation is greatest far from the meniscus, creating
inversion of the density which can lead to fluid motion; although isothermal,
this is somewhat like the Benard problem (a single-phase fluid heated from
below). The other is the intrinsic diffusive instability which results either
in nucleation or in spinodal decomposition at large supersaturations.
Experimental results on a simple binary mixture show interesting oscillations
in heat capacity and optical properties for a wide range of ramp parameters. We
argue that these oscillations arise under conditions where both nonlinearities
are important
All the colours of the rainbow.
Our perception of colour has always been a source of fascination, so it's little wonder that studies of the phenomenon date back hundreds of years. What, though, can modern scientists learn from medieval literature — and how do we go about it
Small angle neutron scattering observation of chain retraction after a large step deformation
The process of retraction in entangled linear chains after a fast nonlinear stretch was detected from time-resolved but quenched small angle neutron scattering (SANS) experiments on long, well-entangled polyisoprene chains. The statically obtained SANS data cover the relevant time regime for retraction, and they provide a direct, microscopic verification of this nonlinear process as predicted by the tube model. Clear, quantitative agreement is found with recent theories of contour length fluctuations and convective constraint release, using parameters obtained mainly from linear rheology. The theory captures the full range of scattering vectors once the crossover to fluctuations on length scales below the tube diameter is accounted for
Unfolding dynamics of proteins under applied force
Understanding the mechanisms of protein folding is a major challenge that is being addressed effectively by collaboration between researchers in the physical and life sciences. Recently, it has become possible to mechanically unfold proteins by pulling on their two termini using local force probes such as the atomic force microscope. Here, we present data from experiments in which synthetic protein polymers designed to mimic naturally occurring polyproteins have been mechanically unfolded. For many years protein folding dynamics have been studied using chemical denaturation, and we therefore firstly discuss our mechanical unfolding data in the context of such experiments and show that the two unfolding mechanisms are not the same, at least for the proteins studied here. We also report unexpected observations that indicate a history effect in the observed unfolding forces of polymeric proteins and explain this in terms of the changing number of domains remaining to unfold and the increasing compliance of the lengthening unstructured polypeptide chain produced each time a domain unfolds
Kramers rate theory of ionization and dissociation of bound states
Calculating the microscopic dissociation rate of a bound state, such as a
classical diatomic molecule, has been difficult so far. The problem was that
standard theories require an energy barrier over which the bound particle (or
state) escapes into the preferred low-energy state. This is not the case when
the long-range repulsion responsible for the barrier is either absent or
screened (as in Cooper pairs, ionized plasma, or biomolecular complexes). We
solve this classical problem by accounting for entropic memory at the
microscopic level. The theory predicts dissociation rates for arbitrary
potentials and is successfully tested on the example of plasma, where it yields
an estimate of ionization in the core of Sun in excellent agreement with
experiments. In biology, the new theory accounts for crowding in
receptor-ligand kinetics and protein aggregation
‘‘Lozenge’’ contour plots in scattering from polymer networks
We present a consistent explanation for the appearance of “lozenge” shapes in contour plots of the two dimensional scattering intensity from stretched polymer networks. By explicitly averaging over quenched variables in a tube model, we show that lozenge patterns arise as a result of chain material that is not directly deformed by the stretch. We obtain excellent agreement with experimental data
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