Economic Credit in Renaissance Florence

What were the social and institutional factors that led to, and reinforced, the precocious emergence of Florentine commercial capitalism,3 especially in the domain of international merchant-banking? The dominant stream of answers, emphasized by economic historians and by economists, focuses on the invention in late-medieval and Renaissance Italy of a variety of innovative business techniques – bills of exchange, double-entry bookkeeping, partnership contracts, commercial courts. If these impressive organizational inventions are interpreted as facets of a broader rise of impersonal market rationality, then a tension emerges in Florentine, and indeed in European, historiography between economic historians and the work of social and political historians, who emphasize the deeply personalistic – mainly familial and clientelist – character of social relationships of the period. But were early-capitalist business techniques really the leading edge of a breakthrough of the market from its traditional social shackles, as the master narrative of modernization would have it? Or instead were economic relations in the market embedded in, and hence reflective of, trends in the surrounding social and political networks of the time, as anthropologically and sociologically oriented economic historians like Karl Polanyi4 have argued? Renaissance Florentine businessmen were not only businessmen, after all, they were also fathers, neighbors, politicians, friends and enemies, and patrons of the arts. But what implications, if any, did this overlap in roles have for the organization and operation of economic markets? In this article, we address these historical questions through both statistical and textual analyses of Florentine commercial credit in the early Quattrocento. Our conclusion will be that commercial credits among Florentine companies were indeed highly correlated with a wide range of non-economic, social relationships among the partners of these companies. Correlations between economic and social relations were highest in the merchant-banking pinnacle of the Florentine economy – precisely in the industries where reliance upon advanced capitalist business techniques was greatest. New capitalist business techniques thus did not displace the oligarchic social networks of the time, but rather built upon and formalized these relationships into markets. In particular, family and neighborhood provided strong ‘traditionalist’ foundations to Renaissance Florentine credit markets. But then republicanism, especially in the institutional form of its elected city council, provided the political scaffolding for personalistic social networks (and thus the economic credit networks built upon them) topologically to ‘open out’ toward expansive liquidity and growth, instead of to close inward into cliques and corruption. Three mechanisms for this institutional impact of republicanism on the emergence of credit markets are discussed: public certification of reputation (onore) through co-optative elections, and both performative and network incorporations of carefully filtered newcomers into relatively open elites5 of merchant-politicians

Energy Audit of a Fitness/Leisure Centre

This paper aims to investigate the energy performance of a fitness/leisure centre. A detailed energy audit has been conducted to determine the energy consumption of the building. Through the collection and analysis of data, the energy performance and Energy Performance Indicators (EnPIs) have been identified. This research indicates that an energy audit can lead to identifying significant energy savings potential in a building. Energy saving opportunities have been identified with a potential to save 158,906kWh of electricity, 81,201kg of CO2 and potentially saving up to e51,230 per annum. A combined heat and power (CHP) plant could yield savings of up to e28,522 annually. A lighting upgrade offers potential savings of 122,976kWh of electricity and e19,373 annually. Due to their high energy demand, commercial buildings have the potential for significant energy savings. The fitness centre was built in 2004 to a high standard and is a well maintained building. Nevertheless, this paper demonstrates the significant potential for energy reduction in buildings such as fitness centres

Topical glyceryl trinitrate for the treatment of tendinopathies: a systematic review

Objective: To produce a best evidence synthesis of the clinical effects of topical glyceryl trinitrate (GTN) in the treatment of tendinopathies. Design: A systematic review of published randomised controlled trials (RCTs) of the use of GTN in patients with tendinopathy. Data sources: MEDLINE, Embase, Scopus and CINAHL from database inception to January 2018. Methods: We examined RCTs comparing the effects of topical GTN with either placebo or other treatments on tendinopathy. Overall quality of each eligible study was determined based on a combined assessment of internal validity, external validity and precision. The level of evidence for each assessed parameter was rated based on the system by van Tulder et al. Results: A total of 10 eligible RCTs were identified including patients with tendinopathy of the rotator cuff (n=4), wrist extensors (n=3), Achilles (n=2) and patellar (n=1) tendons. For all tendinopathies, improvements in pain were significant when comparing GTN versus placebo in the short term (<8 weeks; poor evidence). Significant improvements in midterm outcomes for treatment with GTN versus placebo included the following: patient satisfaction (strong evidence); chances of being asymptomatic with activities of daily living (strong evidence); range of movement (moderate evidence); strength (moderate evidence); pain (at night and with activity; poor evidence) and local tenderness (poor evidence). Patients treated with topical GTN reported a higher incidence of headaches than those who received placebo (moderate evidence). Conclusions and relevance: Treatment of tendinopathies with topical GTN for up to 6 months appears to be superior to placebo and may therefore be a useful adjunct to the treating healthcare professions

Symplectic cohomology and q-intersection numbers

Given a symplectic cohomology class of degree 1, we define the notion of an equivariant Lagrangian submanifold. The Floer cohomology of equivariant Lagrangian submanifolds has a natural endomorphism, which induces a grading by generalized eigenspaces. Taking Euler characteristics with respect to the induced grading yields a deformation of the intersection number. Dehn twists act naturally on equivariant Lagrangians. Cotangent bundles and Lefschetz fibrations give fully computable examples. A key step in computations is to impose the "dilation" condition stipulating that the BV operator applied to the symplectic cohomology class gives the identity. Equivariant Lagrangians mirror equivariant objects of the derived category of coherent sheaves.Comment: 32 pages, 9 figures, expanded introduction, added details of example 7.5, added discussion of sign

The 2020 Five Domains Model: Including Human-Animal Interactions in Assessments of Animal Welfare

Throughout its 25-year history, the Five Domains Model for animal welfare assessment has been regularly updated to include at each stage the latest authenticated developments in animal welfare science thinking. The domains of the most up-to-date Model described here are: 1 Nutrition, 2 Physical Environment, 3 Health, 4 Behavioural Interactions and 5 Mental State. The first four domains focus attention on factors that give rise to specific negative or positive subjective experiences (affects), which contribute to the animal’s mental state, as evaluated in Domain 5. More specifically, the first three domains focus mainly on factors that disturb or disrupt particular features of the body’s internal stability. Each disturbed or disrupted feature generates sensory inputs which are processed by the brain to form specific negative affects. These affects are associated with behaviours that act to restore the body’s internal stability. Each such behaviour is essential for the survival of the animal

Extrapleural pneumonectomy for malignant pleural mesothelioma: Outcomes of treatment and prognostic factors

ObjectiveThis study aimed to evaluate the perioperative and long-term outcomes associated with extrapleural pneumonectomy for patients with malignant pleural mesothelioma.MethodsFrom October 1994 to April 2008, 70 patients were selected for extrapleural pneumonectomy. Univariate analysis was performed using the Kaplan–Meier method and compared using the log-rank test. Multivariate analysis with entering and removing limits of P less than .10 and P greater than .05, respectively, was used. The prognostic factors included age, gender, side of disease, asbestos exposure, histology, positron emission tomography, date of surgery, neoadjuvant chemotherapy, completeness of cytoreduction, lymph node involvement, perioperative morbidity, adjuvant radiotherapy, and pemetrexed-based chemotherapy.ResultsThe mean age of patients was 55 years (standard deviation = 10). Fifty-eight patients had epithelial tumors. Six patients received neoadjuvant chemotherapy, 28 patients received adjuvant radiotherapy, and 16 patients received postoperative pemetrexed-based chemotherapy. Forty-four patients had no lymph node involvement. The perioperative morbidity and mortality were 37% and 5.7%, respectively. Complications included hemothorax (n = 7), atrial fibrillation (n = 6), empyema (n = 4), bronchopulmonary fistula (n = 3), right-sided heart failure (n = 2), pneumonia (n = 1), constrictive pericarditis (n = 1), acute pulmonary edema (n = 1), small bowel herniation (n = 1), and disseminated intravascular coagulopathy (n = 1). The median survival was 20 months, with a 3-year survival of 30%. Asbestos exposure, negative lymph node involvement, and receipt of adjuvant radiation or postoperative pemetrexed-based chemotherapy were associated with improved survival on both univariate and multivariate analyses.ConclusionThe present study supports the use of extrapleural pneumonectomy-based multimodal therapy in carefully selected patients with malignant pleural mesothelioma

Shallow seismic reflection profile of the Meers fault, Comanche County, Oklahoma

This is the publisher's version, also available electronically from “http://onlinelibrary.wiley.com”.A high-resolution seismic-reflection survey was conducted across the Meers fault in Comanche County, Oklahoma, in an attempt to determine the shallow structure associated with the fault zone. A downhole .50-caliber rifle was used as the seismic-energy source. Two 100-Hz geophones were connected in series at each receiver station. A 1.22-m station spacing was used for both source and receiver. Field recording parameters were set to optimize seismic reflections in the 40–150 millisecond range. A pre-analog-to-digital low-cut filter (24 dB/octave rolloff with −3 dB point of 220 Hz) resulted in dominant frequencies in excess of 150 Hz. Several interpretable reflection events between 40 and 120 msec on the processed seismic section provide a clear picture of the shallow structure. Reverse faulting is evident not only at the scarp itself but also on both the upthrown (north) and downthrown (south) portions of the line. This suggests the fault zone extends at least 180 m in both directions (north and south) from the scarp itself. Recent movement appears only to have occurred along the major fault associated with the scarp. The northern portion of the seismic line is characterized by gentle folding, which is not present on the southern portion

The effectiveness and satisfaction of web-based physiotherapy in people with spinal cord injury: a pilot randomised controlled trial

Study Design: Pilot randomised controlled trial. Objectives: The aims of this study were to evaluate the effectiveness and participant satisfaction of web-based physiotherapy for people with Spinal Cord Injury (SCI). Setting: Community patients of a national spinal injury unit in a university teaching hospital, Scotland, UK. Methods: Twenty-four participants were recruited and randomised to receive eight weeks of web-based physiotherapy (intervention), twice per week, or usual care (control). Individual exercise programmes were prescribed based upon participant’s abilities. The intervention was delivered via a website (www.webbasedphysio.com) and monitored and progressed remotely by the physiotherapist. Results: Participants logged on to the website an average of 1.4±0.8 times per week. Between-group differences, although not significant were more pronounced for the 6 minute walk test. Participants were positive about using web-based physiotherapy and stated they would be happy to use it again and would recommend it to others. Overall it was rated as either good or excellent. Conclusions: Web-based physiotherapy was feasible and acceptable for people with SCI. Participants achieved good compliance with the intervention, rated the programme highly and beneficial for health and well-being at various states post injury. The results of this study warrant further work with a more homogenous sample

A large geometric distortion in the first photointermediate of rhodopsin, determined by double-quantum solid-state NMR

Double-quantum magic-angle-spinning NMR experiments were performed on 11,12-C-13(2)-retinylidene-rhodopsin under illumination at low temperature, in order to characterize torsional angle changes at the C11-C12 photoisomerization site. The sample was illuminated in the NMR rotor at low temperature (similar to 120 K) in order to trap the primary photointermediate, bathorhodopsin. The NMR data are consistent with a strong torsional twist of the HCCH moiety at the isomerization site. Although the HCCH torsional twist was determined to be at least 40A degrees, it was not possible to quantify it more closely. The presence of a strong twist is in agreement with previous Raman observations. The energetic implications of this geometric distortion are discussed