Development and Implementation of a Remote- Sensing and In-situ Data Assimilating Version of CMAQ for Operational PM\u3csub\u3e2.5\u3c/sub\u3e Forecasting Part 1: MODIS Aerosol Optical Depth (AOD) Data- Assimilation Design and Testing

Air quality forecasts are now routinely used to understand when air pollution may reach unhealthy levels. For the first time, an operational air quality forecast model that includes the assimilation of remotely-sensed aerosol optical depth and ground based PM2.5 observations is being used. The assimilation enables quantifiable improvements in model forecast skill, which improves confidence in the accuracy of the officially-issued forecasts. This helps air quality stakeholders be more effective in taking mitigating actions (reducing power consumption, ridesharing, etc.) and avoiding exposures that could otherwise result in more serious air quality episodes or more deleterious health effects

Development and Implementation of a Remote- Sensing and In-situ Data Assimilating Version of CMAQ for Operational PM\u3csub\u3e2.5\u3c/sub\u3e Forecasting Part 1: MODIS Aerosol Optical Depth (AOD) Data- Assimilation Design and Testing

Air quality forecasts are now routinely used to understand when air pollution may reach unhealthy levels. For the first time, an operational air quality forecast model that includes the assimilation of remotely-sensed aerosol optical depth and ground based PM2.5 observations is being used. The assimilation enables quantifiable improvements in model forecast skill, which improves confidence in the accuracy of the officially-issued forecasts. This helps air quality stakeholders be more effective in taking mitigating actions (reducing power consumption, ridesharing, etc.) and avoiding exposures that could otherwise result in more serious air quality episodes or more deleterious health effects

Narrow-band imaging versus white light for the detection of proximal colon serrated lesions: a randomized, controlled trial

Background The value of narrow-band imaging (NBI) for detecting serrated lesions is unknown. Objective To assess NBI for the detection of proximal colon serrated lesions. Design Randomized, controlled trial. Setting Two academic hospital outpatient units. Patients Eight hundred outpatients 50 years of age and older with intact colons undergoing routine screening, surveillance, or diagnostic examinations. Interventions Randomization to colon inspection in NBI versus white-light colonoscopy. Main Outcome Measurements The number of serrated lesions (sessile serrated polyps plus hyperplastic polyps) proximal to the sigmoid colon. Results The mean inspection times for the whole colon and proximal colon were the same for the NBI and white-light groups. There were 204 proximal colon lesions in the NBI group and 158 in the white light group (P = .085). Detection of conventional adenomas was comparable in the 2 groups. Limitations Lack of blinding, endoscopic estimation of polyp location. Conclusion NBI may increase the detection of proximal colon serrated lesions, but the result in this trial did not reach significance. Additional study of this issue is warranted. (Clinical trial registration number: NCT01572428.

The Human Phenotype Ontology in 2024: phenotypes around the world.

The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similarity and machine learning algorithms. The HPO has widespread applications in clinical diagnostics and translational research, including genomic diagnostics, gene-disease discovery, and cohort analytics. In recent years, groups around the world have developed translations of the HPO from English to other languages, and the HPO browser has been internationalized, allowing users to view HPO term labels and in many cases synonyms and definitions in ten languages in addition to English. Since our last report, a total of 2239 new HPO terms and 49235 new HPO annotations were developed, many in collaboration with external groups in the fields of psychiatry, arthrogryposis, immunology and cardiology. The Medical Action Ontology (MAxO) is a new effort to model treatments and other measures taken for clinical management. Finally, the HPO consortium is contributing to efforts to integrate the HPO and the GA4GH Phenopacket Schema into electronic health records (EHRs) with the goal of more standardized and computable integration of rare disease data in EHRs

Case Reports1. A Late Presentation of Loeys-Dietz Syndrome: Beware of TGFβ Receptor Mutations in Benign Joint Hypermobility

Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations in the transforming growth factor beta (TGFβ) receptor genes TGFBR1 and TGFBR2. Mean age at death is 26.1 years, most often due to aortic dissection. We report an unusually late presentation of LDS, diagnosed following elective surgery in a female with a long history of joint hypermobility. Methods: A 51-year-old Caucasian lady complained of chest pain and headache following a dural leak from spinal anaesthesia for an elective ankle arthroscopy. CT scan and echocardiography demonstrated a dilated aortic root and significant aortic regurgitation. MRA demonstrated aortic tortuosity, an infrarenal aortic aneurysm and aneurysms in the left renal and right internal mammary arteries. She underwent aortic root repair and aortic valve replacement. She had a background of long-standing joint pains secondary to hypermobility, easy bruising, unusual fracture susceptibility and mild bronchiectasis. She had one healthy child age 32, after which she suffered a uterine prolapse. Examination revealed mild Marfanoid features. Uvula, skin and ophthalmological examination was normal. Results: Fibrillin-1 testing for Marfan syndrome (MFS) was negative. Detection of a c.1270G > C (p.Gly424Arg) TGFBR2 mutation confirmed the diagnosis of LDS. Losartan was started for vascular protection. Conclusions: LDS is a severe inherited vasculopathy that usually presents in childhood. It is characterized by aortic root dilatation and ascending aneurysms. There is a higher risk of aortic dissection compared with MFS. Clinical features overlap with MFS and Ehlers Danlos syndrome Type IV, but differentiating dysmorphogenic features include ocular hypertelorism, bifid uvula and cleft palate. Echocardiography and MRA or CT scanning from head to pelvis is recommended to establish the extent of vascular involvement. Management involves early surgical intervention, including early valve-sparing aortic root replacement, genetic counselling and close monitoring in pregnancy. Despite being caused by loss of function mutations in either TGFβ receptor, paradoxical activation of TGFβ signalling is seen, suggesting that TGFβ antagonism may confer disease modifying effects similar to those observed in MFS. TGFβ antagonism can be achieved with angiotensin antagonists, such as Losartan, which is able to delay aortic aneurysm development in preclinical models and in patients with MFS. Our case emphasizes the importance of timely recognition of vasculopathy syndromes in patients with hypermobility and the need for early surgical intervention. It also highlights their heterogeneity and the potential for late presentation. Disclosures: The authors have declared no conflicts of interes

Global Earth Observation System (GEOS): System Capabilities and the Role for U.S. EPA: Final Report

This report puts forth the recommendations of a community panel on global Earth Observation System (GEOS)

A paleoclimatic reconstruction of the Carboniferous-Permian paleovalley fill in the eastern Paganzo Basin: Insights into glacial extent and deglaciation of southwestern Gondwana

During the mid-Carboniferous, ice centers located in present-day western Argentina disappeared until the late Cenozoic with glaciation of the Andes. The disappearance of mid-Carboniferous glaciers and the subsequent climate shift, recorded in the Paganzo Basin, has been attributed to global events and drivers, such as increased atmospheric CO2 concentrations and the shifting position of Gondwana across the South Pole. However, glaciers continued at the same paleolatitude in eastern South America and did not disappear from Gondwana until the Late Permian. This study investigates links to local drivers that acted in combination with other global drivers to explain the early deglaciation along the western margin of Gondwana. To do this, several outcrops within the eastern portion of the Paganzo Basin in western Argentina were sampled for the Chemical Index of Alteration (CIA) geochemical analyses. Here, we test the applicability of the CIA as a paleoclimate proxy on strata in the Olta-Malanzán paleovalley that historically was thought to have been glaciated. A recent study by the authors has shown that the paleovalley was not glaciated, but owes its origin to extension and excavation by fluvial processes. However, the late Paleozoic stratigraphy of this paleovalley system is similar to the rest of the Paganzo Basin. The results from the paleovalley samples show that this area was intermittently humid and arid through time, but with an overall arid profile. This signature is predominantly due to the nature of the paleovalley, which was subjected to rapid burial from frequent rock falls, progradation alluvial fans/fan deltas, and lacustrine sediment gravity flows (Malanzán Fm.), which prevented any significant chemical weathering. While the overall Pennsylvanian climatic signature appears to be relatively arid (Malanzán, Loma Larga, and Solca Fms.), it seems that the climate during the deposition of the late Pennsylvanian and Permian La Colina Formation was more humid than previously thought.Fil: Pauls, Kathryn N.. University of Wisconsin; Estados UnidosFil: Isbell, John L.. University of Wisconsin; Estados UnidosFil: McHenry, Lindsay. University of Wisconsin; Estados UnidosFil: Limarino, Carlos Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; ArgentinaFil: Moxness, Levi D.. University of Wisconsin; Estados UnidosFil: Schencman, Laura Jazmín. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Geológicas. Área de Sedimentología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; Argentin