Designing biodegradable alternatives to commodity polymers

The development and widespread adoption of commodity polymers changed societal landscapes on a global scale. Without the everyday materials used in packaging, textiles, construction and medicine, our lives would be unrecognisable. Through decades of use, however, the environmental impact of waste plastics has become grimly apparent, leading to sustained pressure from environmentalists, consumers and scientists to deliver replacement materials. The need to reduce the environmental impact of commodity polymers is beyond question, yet the reality of replacing these ubiquitous materials with sustainable alternatives is complex. In this tutorial review, we will explore the concepts of sustainable design and biodegradability, as applied to the design of synthetic polymers intended for use at scale. We will provide an overview of the potential biodegradation pathways available to polymers in different environments, and highlight the importance of considering these pathways when designing new materials. We will identify gaps in our collective understanding of the production, use and fate of biodegradable polymers: from identifying appropriate feedstock materials, to considering changes needed to production and recycling practices, and to improving our understanding of the environmental fate of the materials we produce. We will discuss the current standard methods for the determination of biodegradability, where lengthy experimental timescales often frustrate the development of new materials, and highlight the need to develop better tools and models to assess the degradation rate of polymers in different environments

Donepezil Effects on Mood in Patients with Schizophrenia and Schizoaffective Disorder

Donepezil, 5 mg/d for 6 wk then 10 mg/d for 6 wk, and placebo daily for 12 wk in a double-blind cross-over paradigm, was added to the therapeutic regimen of 13 patients with schizophrenia or schizoaffective disorders, clinically stable on atypical antipsychotic medications. Patients had varying degrees of depressive symptoms, ranging from no depression to clinically significant depression. There was no worsening or induction of depression in individual patients or the group as a whole. In addition there was a statistically significant antidepressant effect in the group as a whole during the donepezil condition and a clinically significant antidepressant effect in the patients with clinically significant depressive symptoms, although there were not enough depressed patients in the group to conclude that donepezil may have antidepressant effects. Thus, in this study, donepezil did not induce or worsen depressive symptoms in schizophrenic and schizoaffective disorder patients

A Data Driven Approach to Audiovisual Speech Mapping

The concept of using visual information as part of audio speech processing has been of significant recent interest. This paper presents a data driven approach that considers estimating audio speech acoustics using only temporal visual information without considering linguistic features such as phonemes and visemes. Audio (log filterbank) and visual (2D-DCT) features are extracted, and various configurations of MLP and datasets are used to identify optimal results, showing that given a sequence of prior visual frames an equivalent reasonably accurate audio frame estimation can be mapped

Foley Music: Learning to Generate Music from Videos

In this paper, we introduce Foley Music, a system that can synthesize plausible music for a silent video clip about people playing musical instruments. We first identify two key intermediate representations for a successful video to music generator: body keypoints from videos and MIDI events from audio recordings. We then formulate music generation from videos as a motion-to-MIDI translation problem. We present a Graph$-$Transformer framework that can accurately predict MIDI event sequences in accordance with the body movements. The MIDI event can then be converted to realistic music using an off-the-shelf music synthesizer tool. We demonstrate the effectiveness of our models on videos containing a variety of music performances. Experimental results show that our model outperforms several existing systems in generating music that is pleasant to listen to. More importantly, the MIDI representations are fully interpretable and transparent, thus enabling us to perform music editing flexibly. We encourage the readers to watch the demo video with audio turned on to experience the results.Comment: ECCV 2020. Project page: http://foley-music.csail.mit.ed

Adaptive Optics Imaging of QSOs with Double-Peaked Narrow Lines: Are they Dual AGNs?

Active galaxies hosting two accreting and merging super-massive black holes (SMBHs) -- dual Active Galactic Nuclei (AGN) -- are predicted by many current and popular models of black hole-galaxy co-evolution. We present here the results of a program that has identified a set of probable dual AGN candidates based on near Infra-red (NIR) Laser Guide-Star Adaptive Optics (LGS AO) imaging with the Keck II telescope. These candidates are selected from a complete sample of radio-quiet Quasi-stellar Objects (QSOs) drawn from the Sloan Digital Sky Survey (SDSS), which show double-peaked narrow AGN emission lines. Of the twelve AGNs imaged, we find six with double galaxy structure, of which four are in galaxy mergers. We measure the ionization of the two velocity components in the narrow AGN lines to test the hypothesis that both velocity components come from an active nucleus. The combination of a well-defined parent sample and high-quality imaging allows us to place constraints on the fraction of SDSS QSOs that host dual accreting black holes separated on kiloparsec (kpc) scales: ~0.3%-0.65%. We derive from this fraction the time spent in a QSO phase during a typical merger and find a value that is much lower than estimates that arise from QSO space densities and galaxy merger statistics. We discuss possible reasons for this difference. Finally, we compare the SMBH mass distributions of single and dual AGN and find little difference between the two within the limited statistics of our program, hinting that most SMBH growth happens in the later stages of a merger process.Comment: 9 pages, 4 figures, 1 table; accepted to the Astrophysical Journa