Discovery of a New Nearby Star

We report the discovery of a nearby star with a very large proper motion of 5.06 +/- 0.03 arcsec/yr. The star is called SO025300.5+165258 and referred to herein as HPMS (high proper motion star). The discovery came as a result of a search of the SkyMorph database, a sensitive and persistent survey that is well suited for finding stars with high proper motions. There are currently only 7 known stars with proper motions > 5 arcsec/yr. We have determined a preliminary value for the parallax of 0.43 +/- 0.13 arcsec. If this value holds our new star ranks behind only the Alpha Centauri system (including Proxima Centauri) and Barnard's star in the list of our nearest stellar neighbors. The spectrum and measured tangential velocity indicate that HPMS is a main-sequence star with spectral type M6.5. However, if our distance measurement is correct, the HPMS is underluminous by 1.2 +/- 0.7 mag.Comment: 5 pages, 3 figures. Submitted to ApJ Letter

Is the biology of breast cancer changing? A study of hormone receptor status 1984-1986 and 1996-1997

Using archived tumours, those from 1984-1986 and 1996-1997 underwent immunohistochemistry for hormone receptors and grade analysis. A significant shift towards more ER-positive and low-grade disease was found; this appears to reflect screening practices, but could still influence survival

The frontier of darkness: the cases of GRB 040223, GRB 040422, GRB 040624

Understanding the reasons for the faintness of the optical/near-infrared afterglows of the so-called dark bursts is essential to assess whether they form a subclass of GRBs, and hence for the use of GRBs in cosmology. With VLT and other ground-based telescopes, we searched for the afterglows of the INTEGRAL bursts GRB 040223, GRB 040422 and GRB 040624 in the first hours after the triggers. A detection of a faint afterglow and of the host galaxy in the K band was achieved for GRB 040422, while only upper limits were obtained for GRB 040223 and GRB 040624, although in the former case the X-ray afterglow was observed. A comparison with the magnitudes of a sample of afterglows clearly shows the faintness of these bursts, which are good examples of a population that an increasing usage of large diameter telescopes is beginning to unveil.Comment: 4 pages, 2 figures. To appear in the proceedings of the 16th Annual October Astrophysics Conference in Maryland "Gamma Ray Bursts in the Swift Era", eds. S. Holt, N. Gehrels & J. Nouse

Risk of testicular germ-cell tumours in relation to childhood physical activity

The US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) case–control study of testicular germ-cell tumours (TGCTs) enrolled participants and their mothers in 2002–2005. Hours of sports or vigorous childhood physical activity per week were ascertained for three time periods; 1st–5th grades, 6th–8th grades and 9th–12th grades. Son- and mother-reports were analysed separately and included 539 control son–mother pairs and 499 case son–mother pairs. Odds ratios and 95% confidence intervals were produced. The analysis of the sons' responses found no relationship between childhood physical activity and TGCT, while the mothers' analysis found an inverse association, which was solely due to nonseminoma. Future studies should seek to validate responses further using recorded information sources such as school records

Reversal of the Charge Transfer between Host and Dopant Atoms in Semiconductor Nanocrystals

We present ab initio density functional calculations that show P (Al) dopant atoms in small hydrogen-terminated Si crystals to be negatively (positively) charged. These signs of the dopant charges are reversed relative to the same dopants in bulk Si. We predict this novel reversal of the dopant charge (and electronic character of the doping) to occur at crystal sizes of order 100 Si atoms. We explain it as a result of competition between fundamental principles governing charge transfer in bulk semiconductors and molecules and predict it to occur in nanocrystals of most semiconductors.Comment: 4 pages, 4 figures (3 in color), 2 table

ruvA Mutants that resolve Holliday junctions but do not reverse replication forks

RuvAB and RuvABC complexes catalyze branch migration and resolution of Holliday junctions (HJs) respectively. In addition to their action in the last steps of homologous recombination, they process HJs made by replication fork reversal, a reaction which occurs at inactivated replication forks by the annealing of blocked leading and lagging strand ends. RuvAB was recently proposed to bind replication forks and directly catalyze their conversion into HJs. We report here the isolation and characterization of two separation-of-function ruvA mutants that resolve HJs, based on their capacity to promote conjugational recombination and recombinational repair of UV and mitomycin C lesions, but have lost the capacity to reverse forks. In vivo and in vitro evidence indicate that the ruvA mutations affect DNA binding and the stimulation of RuvB helicase activity. This work shows that RuvA's actions at forks and at HJs can be genetically separated, and that RuvA mutants compromised for fork reversal remain fully capable of homologous recombination

Dissipationless Collapse of Spherical Protogalaxies and the Fundamental Plane

Following on from the numerical work of Capelato, de Carvalho & Carlberg (1995, 1997), where dissipationless merger simulations were shown to reproduce the "Fundamental Plane" (FP) of elliptical galaxies, we investigate whether the end products of pure, spherically symmetric, one-component dissipationless {\it collapses} could also reproduce the FP. Past numerical work on collisionless collapses have addressed important issues on the dynamical/structural characteristics of collapsed equilibrium systems. However, the study of collisionless collapse in the context of the nature of the FP has not been satisfactorily addressed yet. Our aim in this paper is to focus our attention on the resulting collapse of simple one-component spherical models with a range of different initial virial coefficients. We find that the characteristic correlations of the models are compatible with virialized, centrally homologous systems. Our results strengthen the idea that merging may be a fundamental ingredient in forming non-homologous objects.Comment: 9 pages, 4 Postscript figures, Astronomy & Astrophysics in press (2002). Abstract placement correcte

Preliminary INTEGRAL Analysis of GRB040106

On January 6th 2004, the IBAS burst alert system triggered the 8th gamma-ray burst (GRB) to be detected by the INTEGRAL satellite. The position was determined and publicly distributed within 12s, enabling ESA's XMM-Newton to take advantage of a ToO observation just 5 hours later during which the x-ray afterglow was detected. Observations at optical wavelengths also revealed the existence of a fading optical source. The GRB is ~52s long with 2 distinct peaks separated by ~24s. At gamma-ray energies the burst was the weakest detected by INTEGRAL up to that time with a flux in the 20-200 keV band of 0.57 photons/cm^2/s. Nevertheless, it was possible to determine its position and extract spectra and fluxes. Here we present light curves and the results of imaging, spectral and temporal analyses of the prompt emission and the onset of the afterglow from INTEGRAL data.Comment: 4 pages. To appear in proceedings of the 5th INTEGRAL Workshop, "The INTEGRAL Universe", February 16-20, 2004, Munich. (Typos corrected in author addresses, some refs added