TREATMENT FOR PERSONS WITH HEROIN ADDICTION

Heroin addiction is devastating to both the person addicted and to society. Attempts to treat heroin addiction have proved difficult due to the extreme addictive qualities of the drug. Medication-assisted recovery or pharmacotherapy, such as methadone and buprenorphine, are controversial in that it is providing a medication that has similar qualities of heroin itself. Behavioral treatments alone have limited success due to many factors. The literature presented will provide a look at heroin and heroin addiction, as well as a comprehensive study of outpatient treatments that are currently being used. The purpose of this study is to determine the most effective way to treat heroin addiction as the number of overdoses and death are on the rise

Embedded Relative Navigation Sensor Fusion Algorithms for Autonomous Rendezvous and Docking Missions

bd Systems (a subsidiary of SAIC) has developed a suite of embedded relative navigation sensor fusion algorithms to enable NASA autonomous rendezvous and docking (AR&D) missions. Translational and rotational Extended Kalman Filters (EKFs) were developed for integrating measurements based on the vehicles' orbital mechanics and high-fidelity sensor error models and provide a solution with increased accuracy and robustness relative to any single relative navigation sensor. The filters were tested tinough stand-alone covariance analysis, closed-loop testing with a high-fidelity multi-body orbital simulation, and hardware-in-the-loop (HWIL) testing in the Marshall Space Flight Center (MSFC) Flight Robotics Laboratory (FRL)

A Randomized Controlled Trial of Interleukin-1 Receptor Antagonist in a Rabbit Model of Ascending Infection in Pregnancy

Objective: To determinewhether treatment with interleukin-1 receptor antagonist (IL1-ra) would affect amniotic fluid concentrations of tumor necrosis factor alpha (TNF-α) and prostaglandins or clinical or microbiological outcomes in a model of ascending bacterial infection in pregnancy. Methods: Timed pregnant New Zealand white rabbits at 70% of gestation underwent endoscopic inoculation of the cervices with 10(6)–10(6) cfu Escherichia coli . Animals were randomly assigned in a blinded manner to a 5-h intravenous infusion of human IL1-ra (10 mg/kg) or placebo beginning 1 – 2 h after inoculation. Blood was drawn fromthe does for assay of serum IL1-ra concentration before inoculation, at mid-infusion, after the infusion ended and at necropsy. At necropsy, temperature and cultures were taken, and aspirated amniotic fluid was pooled for assays of TNF-α, prostaglandin E(2) (PGE(2)) and IL1-ra. Results: Serum IL1-ra concentrations rose to a mean of 2 mg/ml at mid-infusion and fell markedly after the infusion to concentrations barely detectable at necropsy. Between the two groups, there were no significant differences in the rates of fever or positive cultures or in amniotic fluid concentrations of PGE(2) or TNF-α.One unique finding was the demonstration that administration of human IL1-ra to the does resulted inmeasurable concentrationsof human IL1-ra in the amniotic fluid. Conclusions: Treatment with an intravenous infusion of human IL1-ra after cervical inoculation with E. coli did not affect clinical or microbiological outcomes or amniotic fluid concentrations of TNF-α or PGE(2). This experiment provides the first demonstration of passageof human IL1-ra from the maternal bloodstreamto the amniotic fluid

Gender Differences Concerning Physical Activity Beliefs and Practices among Fourth and Fifth Graders in Rural Virginia

Cardiovascular disease is the leading cause of death in the United States. Physical activity (PA) is a known preventative factor. It is recommended that children participate in 60 minutes of PA daily, but most do not meet these guidelines. Further, boys, aged 8-17 years, spend more time in PA than girls of the same age. The purposes of this study were to identify gender differences in PA beliefs and practices among fourth and fifth graders and to determine when gender disparities in self-confidence regarding PA and fitness occur.  Subjects were 41 fourth (19 boys; 22 girls) and 33 fifth (16 boys; 17 girls) graders in a public elementary school in the rural northwest. They participated in the FitnessGram, a nationwide assessment of flexibility, aerobic capacity, and muscular strength and endurance, and a proctored survey about their PA beliefs, self-confidence, and participation. There were no differences in FitnessGram data between boys and girls for aerobic capacity or muscular strength and endurance, but girls had increased flexibility when compared to boys in both grades. Importantly, survey results showed fifth grade girls had less confidence they could improve their physical fitness (p = 0.002) or their overall health (p = 0.004) when compared to fourth grade girls. Research is needed to determine how these changes in self-confidence contribute to the gender gap in time spent in PA. We recommend physical education programs throughout all grades teach healthy behaviors, including time spent in PA, and work to build and maintain self-confidence in girls

Tropospheric sources and sinks of gas-phase acids in the Colorado Front Range

We measured organic and inorganic gas-phase acids in the Front Range of Colorado to better understand their tropospheric sources and sinks using a high-resolution time-of-flight chemical ionization mass spectrometer. Measurements were conducted from 4 to 13 August 2014 at the Boulder Atmospheric Observatory during the Front Range Air Pollution and Photochemistry Éxperiment. Diurnal increases in mixing ratios are consistent with photochemical sources of HNO3, HNCO, formic, propionic, butyric, valeric, and pyruvic acid. Vertical profiles taken on the 300&thinsp;m tower demonstrate net surface-level emissions of alkanoic acids, but net surface deposition of HNO3 and pyruvic acid. The surface-level alkanoic acid source persists through both day and night, and is thus not solely photochemical. Reactions between O3 and organic surfaces may contribute to the surface-level alkanoic acid source. Nearby traffic emissions and agricultural activity are a primary source of propionic, butyric, and valeric acids, and likely contribute photochemical precursors to HNO3 and HNCO. The combined diel and vertical profiles of the alkanoic acids and HNCO are inconsistent with dry deposition and photochemical losses being the only sinks, suggesting additional loss mechanisms.</p

Ethnicity and incidence of Hodgkin lymphoma in Canadian population

<p>Abstract</p> <p>Background</p> <p>Research has shown that ethnicity is a significant predictor of Hodgkin lymphoma (HL). Variations in cancer incidence among ethnic groups in the same country can lead to important information in the search for etiological factors. Other risk factors important in the etiology of HL are medical history and exposure to pesticides. In this report we investigated the association between ethnicity and HL in the presence of medical history, and exposure to pesticides.</p> <p>Methods</p> <p>The data resulting from a matched population-based case-control study conducted in six provinces of Canada (Ontario, Quebec, Manitoba, Saskatchewan, Alberta, and British Columbia) was analyzed to determine whether or not there was any association between ethnicity and incidence of HL when adjusted for personal medical history and pesticide exposure. Information on ethnicity, personal medical history, and pesticide exposure was collected by questionnaires via mail on 316 men diagnosed with HL; and on 1506 controls. A conditional logistic regression was utilized and results were presented as odds ratios and 95% confidence intervals.</p> <p>Results</p> <p>In our study population, the distribution of ethnic groups was: 38.5% North American, 15% British, 8.4% Western European, 8.2% Eastern European, 1.7% Asian, 1.4% Scandinavian and 27% of other ethnic origin. Compared to North Americans (i) the risk of HL was greater among the Eastern European descendents (Odds Ratio (OR_adj): 1.82; 95% confidence interval (CI): 1.02, 3.25) and Western European (OR_adj: 1.62; 95% CI: 0.95–2.76) descent population (borderline significance at 5% level); and (ii) the risk of HL was lower in Asian descents. Diagnosis with measles (OR_adj: 0.72, 95% C.I.: 0.53–0.98) and/or positive history of allergy desensitization shots (OR_adj: 0.55, 95% C.I.: 0.30–0.99) were negatively associated with the incidence of HL, while diagnosis with acne (OR_adj: 2.12, 95% C.I.: 1.19–3.78), shingles (OR_adj: 2.41, 95% C.I.: 1.38–4.22) and positive family history of cancer (OR_adj: 1.93, 95% C.I.: 1.40–2.65) increased the risk of HL. Exposure to individual herbicide dichlorprop showed an increased risk of HL (OR_adj: 6.35, 95% C.I.: 1.56–25.92).</p> <p>Conclusion</p> <p>In Canada, compared to North Americans descendents, the risk of HL was significantly greater among the Eastern European and Western European descent population. Our results related to association between ethnicity and HL support the findings reported by other researchers. Our data showed that subjects who were diagnosed with measles or had allergy desensitization shots negatively associated with the incidence of HL; and other medical conditions, ever diagnosed with acne, and positive family history of cancer were positively associated with the incidence of HL.</p

Sources and Secondary Production of Organic Aerosols in the Northeastern United States during WINTER

Most intensive field studies investigating aerosols have been conducted in summer, and thus, wintertime aerosol sources and chemistry are comparatively poorly understood. An aerosol mass spectrometer was flown on the National Science Foundation/National Center for Atmospheric Research C‐130 during the Wintertime INvestigation of Transport, Emissions, and Reactivity (WINTER) 2015 campaign in the northeast United States. The fraction of boundary layer submicron aerosol that was organic aerosol (OA) was about a factor of 2 smaller than during a 2011 summertime study in a similar region. However, the OA measured in WINTER was almost as oxidized as OA measured in several other studies in warmer months of the year. Fifty‐eight percent of the OA was oxygenated (secondary), and 42% was primary (POA). Biomass burning OA (likely from residential heating) was ubiquitous and accounted for 33% of the OA mass. Using nonvolatile POA, one of two default secondary OA (SOA) formulations in GEOS‐Chem (v10‐01) shows very large underpredictions of SOA and O/C (5×) and overprediction of POA (2×). We strongly recommend against using that formulation in future studies. Semivolatile POA, an alternative default in GEOS‐Chem, or a simplified parameterization (SIMPLE) were closer to the observations, although still with substantial differences. A case study of urban outflow from metropolitan New York City showed a consistent amount and normalized rate of added OA mass (due to SOA formation) compared to summer studies, although proceeding more slowly due to lower OH concentrations. A box model and SIMPLE perform similarly for WINTER as for Los Angeles, with an underprediction at ages \u3c6 hr, suggesting that fast chemistry might be missing from the models

Advancing the estimation of future climate impacts within the United States

Evidence of the physical and economic impacts of climate change is a critical input to policy development and decision-making. In addition to the magnitude of potential impacts, detailed estimates of where, when, and to whom those damages may occur; the types of impacts that will be most damaging; uncertainties in these damages; and the ability of adaptation to reduce potential risks are all interconnected and important considerations. This study utilizes the reduced-complexity model, the Framework for Evaluating Damages and Impacts (FrEDI), to rapidly project economic and physical impacts of climate change across 10 000 future scenarios for multiple impact sectors, regions, and populations within the contiguous United States (US). Results from FrEDI show that net national damages increase overtime, with mean climate-driven damages estimated to reach USD 2.9 trillion (95 % confidence interval (CI): USD 510 billion to USD 12 trillion) annually by 2090. Detailed FrEDI results show that for the analyzed sectors the majority of annual long-term (e.g., 2090) damages are associated with climate change impacts to human health, including mortality attributable to climate-driven changes in temperature and air pollution (O3 and PM2.5) exposure. Regional results also show that annual long-term climate-driven damages vary geographically. The Southeast (all regions are as defined in Fig. 5) is projected to experience the largest annual damages per capita (mean: USD 9300 per person annually; 95 % CI: USD 1800–USD 37 000 per person annually), whereas the smallest damages per capita are expected in the Southwest (mean: USD 6300 per person annually; 95 % CI: USD 840–USD 27 000 per person annually). Climate change impacts may also broaden existing societal inequalities, with, for example, Black or African Americans being disproportionately affected by additional premature mortality from changes in air quality. Lastly, FrEDI projections are extended through 2300 to estimate the net present climate-driven damages within US borders from marginal changes in greenhouse gas emissions. Combined, this analysis provides the most detailed illustration to date of the distribution of climate change impacts within US borders.</p

The impact of neonatal breast-feeding on growth trajectories of youth exposed and unexposed to diabetes in utero: the EPOCH Study

ObjectiveTo evaluate the influence of breastfeeding on the body mass index (BMI) growth trajectory from birth through 13 years of age among offspring of diabetic pregnancies (ODP) and offspring of non-diabetic pregnancies (ONDP) participating in the EPOCH study.SubjectsThere were 94 ODP and 399 ONDP who had multiple BMI measures obtained from birth throughout childhood. A measure of breast milk-months was derived from maternal self-report to categorize breastfeeding status as adequate (≥6 breast milk-months) or low (<6 breast milk-months). Mixed linear effects models were constructed to assess the impact of breastfeeding on the BMI growth curves during infancy (birth to 27 months) and childhood (27 months to 13 years).ResultsODP who were adequately breastfed had a slower BMI growth trajectory during childhood (p=0.047) and slower period-specific growth velocity with significant differences between 4 to 6 years of age (p=0.03) and 6 to 9 years of age (p=0.01) compared to ODP with low breastfeeding. A similar pattern was seen in the ONDP, with adequate breastfeeding associated with lower average BMI in infancy (p=0.03) and childhood (p=0.0002) and a slower growth trajectory in childhood (p=0.0002). Slower period-specific growth velocity was seen among the ONDP associated with adequate breastfeeding with significant differences between 12–26 months (p=0.02), 4–6 years (p=0.03), 6–9 years (p=0.0001) and 9–13 years of age (p<.0001).ConclusionOur study provides novel evidence that breastfeeding is associated with long-term effects on childhood BMI growth that extend beyond infancy into early and late childhood. Importantly, these effects are also present in the high-risk offspring, exposed to overnutrition during pregnancy. Breastfeeding in the early postnatal period may represent a critical opportunity to reduce the risk of childhood obesity

Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer

Immune checkpoint inhibitors (ICIs) are effective in treating a variety of malignancies, including metastatic bladder cancer. A generally accepted hypothesis suggests that ICIs induce tumor regressions by reactivating a population of endogenous tumor-infiltrating lymphocytes (TILs) that recognize cancer neoantigens. Although previous studies have identified neoantigen-reactive TILs from several types of cancer, no study to date has shown whether or not neoantigen-reactive TILs can be found in bladder tumors. To address this, we generated TIL cultures from patients with primary bladder cancer and tested their ability to recognize tumor-specific mutations. We found that CD4+ TILs from one patient recognized mutated C-terminal binding protein 1 (CTBP1Q277R) in an MHC class II-restricted manner. This finding suggests that neoantigen-reactive TILs reside in bladder cancer, which may help explain the effectiveness of immune checkpoint blockade in this disease, and also provides a rationale for the future use of adoptive T-cell therapy targeting neoantigens in bladder cancer