Wages Required for Self-Sufficiency in South Dakota

This publication discusses how much money a South Dakota breadwinner has to earn to be considered self-sufficient. The data presented is at the county level, reflecting the difference in cost of living among the state’s counties. The authors replicate the techniques developed by Diana Pearce in The Self-Sufficiency Standard for South Dakota (2000). Pearce described self-sufficiency as “earning adequate wages to provide for basic needs without additional support.” As Pearce’s publication has become dated and it seems unreasonable to wait for another regional study to update our local data, in respectfully updating her report, we stand on Dr. Pearce’s shoulders

Rural Life Census Data Center Newsletter: South Dakota Net Migration Estimates

Migration brings important changes for both migrants and communities. Migration into a community can mean a new community dynamic: individuals who migrate bring their views of the world with them, and sometimes these ideas, values, and beliefs breed conflict (Blau 1994). And migration out of a community also can bring change: rural counties with high out-migration rates may also experience long-term economic hardships (Johnson 2006). South Dakota is affected by both in-migration and out-migration

Threshold Levels for Selected Rural South Dakota Retail and Service Businesses

What new enterprise would be most likely to suc¬ceed in your community? Is opening a computer store in Buffalo, South Dakota, a good idea? What about a new church? Or a bar? While the goals of churches and taverns differ, the likelihood of success for either can be described in terms of population thresholds. Retail trade is an important part of a rural county’s economy (Blair, Traynor, and Duan 2004). Dehter (1987) saw shopping as a major contributor to high qual¬ity rural life. Each successful rural business improves the economic and social well-being of rural people. Both entrepreneurs and community leaders can use retail threshold calculations to identify the businesses most likely to succeed in rural areas. Retail thresholds are usually calculated at the state level. This report focuses only on South Dakota’s most rural countries. Business pattern data extracted at zip code level allowed us to calculate rural South Dakota’s retail threshold levels. The U.S. Census Bureau provides reliable business data for calculating thresholds

Rural Life Census Data Center Newsletter: Private Industry Change in South Dakota

South Dakota leaders continue to emphasize the importance of economic development. One aspect of assessing economic development is private industry growth. The South Dakota Chamber of Commerce states:Economic development is not a choice but rather a necessity. Economies that are advancing create jobs with higher pay, offer people amenities and necessities, and provide the tax base for schools, infrastructure, and law enforcement plus many of the intangibles known as “quality of life.” (South Dakota Chamber of Commerce 2006). Private sector jobs make up a large percentage of South Dakota’s jobs. Capitalistic economies, like the United States’, depend on the private sector. The taxes paid by private sectors provide better services for all citizens (Stover, Lichty, and Stover 1999). We used Quarterly Workforce Indicator (QWI) data produced by the Census Bureau to assess the most current private sector figures and trends. Data for this report were obtained at http://lehd.did.census.gov/led/datatools/qwiapp.html. These data also give us insight into both where South Dakota’s private sector growth is occurring and where private sector growth lags

Rural Life Census Data Center Newsletter: The U.S. Census Bureau and American Community Survey: Advantages, Uses, and Limitations

The U.S. Census Bureau is supported and funded by the U.S. government and is a widely used source for demographic data. Social, housing, and economic data can easily be obtained from the bureau’s website (www.census.gov). There is broad range of information presented (for example, data on age, sex, household structure, and/or income levels can be shown for any U.S. location [Edmonston and Schultze 1995]). The bureau provides data to the block level (Weeks 2005). According to the U.S. Census Bureau, the block is the smallest geographical unit in which census data can be collected. Blocks usually correspond with city blocks but in rural areas may include several square miles (www.census.gov). Census data can aid research over a range of topics. The data can help one understand sex and age structure changes for a county, can help one recognize housing differences between two or more racial/ethnic groups, can help one observe the difference in income between different types of families, and so on (Edmonston and Schultze 1995). Researchers who need population characteristics for grant purposes find census data to be useful. Because U.S. Census Bureau data is readily available via the Internet, the use of this data by the general public is common. Census data appeals to a wide audience. Political leaders use census data to make informed policy choices, and businesses use census data when planning the placement of industries (Weeks 2005). Because so many individuals rely on the U.S. Census Bureau, it is important to understand the uses and limitations of its data

Final Report - Assessment of Testing Options for the NTR at the INL

One of the main technologies that can be developed to dramatically enhance the human exploration of space is the nuclear thermal rocket (NTR). Several studies over the past thirty years have shown that the NTR can reduce the cost of a lunar outpost, reduce the risk of a human mission to Mars, enable fast transits for most missions throughout the solar system, and reduce the cost and time for robotic probes to deep space. Three separate committees of the National Research Council of the National Academy of Sciences have recommended that NASA develop the NTR. One of the primary issues in development of the NTR is the ability to verify a flight ready unit. Three main methods can be used to validate safe operation of a NTR: 1) Full power, full duration test in an above ground facility that scrubs the rocket exhaust clean of any fission products; 2) Full power , full duration test using the Subsurface Active Filtering of Exhaust (SAFE) technique to capture the exhaust in subsurface strata; 3) Test of the reactor fuel at temperature and power density in a driver reactor with subsequent first test of the fully integrated NTR in space. The first method, the above ground facility, has been studied in the past. The second method, SAFE, has been examined for application at the Nevada Test Site. The third method relies on the fact that the Nuclear Furnace series of tests in 1971 showed that the radioactive exhaust coming from graphite based fuel for the NTR could be completely scrubbed of fission products and the clean hydrogen flared into the atmosphere. Under funding from the MSFC, the Center for Space Nuclear Research (CSNR) at the Idaho National laboratory (INL) has completed a reexamination of Methods 2 and 3 for implementation at the INL site. In short, the effort performed the following: 1) Assess the geology of the INL site and determine a location suitable SAFE testing; 2) Perform calculations of gas transport throughout the geology; 3) Produce a cost estimate of a non-nuclear , sub-scale test using gas injection to validate the computational models; 4) Produce a preliminary cost estimate to build a nuclear furnace equivalent facility to test NTR fuel on a green field location on the INL site. The results show that the INL geology is substantially better suited to the SAFE testing method than the NTS site. The existence of impermeable interbeds just above the sub-surface aquifer ensure that no material from the test, radioactive or not, can enter the water table. Similar beds located just below the surface will prevent any gaseous products from reaching the surface for dispersion. The extremely high permeability of the strata between the interbeds allows rapid dispersion of the rocket exhaust. In addition, the high permeability suggests that a lower back-pressure may develop in the hole against the rocket thrust, which increases safety of operations. Finally, the cost of performing a sub-scale, non-nuclear verification experiment was determined to be $3M. The third method was assessed through discussions with INL staff resident at the site. In essence, any new Category I facility on any DOE site will cost in excess of$250M. Based on the results of this study, a cost estimate for testing a nuclear rocket at the INL site appears to be warranted. Given the fact that a new nuclear fuel may be possible that does not release any fission products, the SAFE testing option appears to be the most affordable

Insulin Responsiveness in Metabolic Syndrome after Eight Weeks of Cycle Training

Introduction Insulin resistance in obesity is decreased after successful diet and exercise. Aerobic exercise training alone was evaluated as an intervention in subjects with the metabolic syndrome. Methods Eighteen nondiabetic, sedentary subjects, 11 with the metabolic syndrome, participated in 8 wk of increasing intensity stationary cycle training. Results Cycle training without weight loss did not change insulin resistance in metabolic syndrome subjects or sedentary control subjects. Maximal oxygen consumption (V˙O2max), activated muscle AMP-dependent kinase, and muscle mitochondrial marker ATP synthase all increased. Strength, lean body mass, and fat mass did not change. The activated mammalian target of rapamycin was not different after training. Training induced a shift in muscle fiber composition in both groups but in opposite directions. The proportion of type 2x fibers decreased with a concomitant increase in type 2a mixed fibers in the control subjects, but in metabolic syndrome, type 2x fiber proportion increased and type 1 fibers decreased. Muscle fiber diameters increased in all three fiber types in metabolic syndrome subjects. Muscle insulin receptor expression increased in both groups, and GLUT4 expression increased in the metabolic syndrome subjects. The excess phosphorylation of insulin receptor substrate 1 (IRS-1) at Ser337 in metabolic syndrome muscle tended to increase further after training in spite of a decrease in total IRS-1. Conclusions In the absence of weight loss, the cycle training of metabolic syndrome subjects resulted in enhanced mitochondrial biogenesis and increased the expression of insulin receptors and GLUT4 in muscle but did not decrease the insulin resistance. The failure for the insulin signal to proceed past IRS-1 tyrosine phosphorylation may be related to excess serine phosphorylation at IRS-1 Ser337, and this is not ameliorated by 8 wk of endurance exercise training

Antilymphoid antibody preconditioning and tacrolimus monotherapy for pediatric kidney transplantation

Objective: Heavy post-transplant immunosuppression may contribute to long-term immunosuppression dependence by subverting tolerogenic mechanisms; thus, we sought to determine if this undesirable consequence could be mitigated by pretransplant lymphoid depletion and minimalistic post-transplant monotherapy. Study design: Lymphoid depletion in 17 unselected pediatric recipients of live (n = 14) or deceased donor kidneys (n = 3) was accomplished with antithymocyte globulin (ATG) (n = 8) or alemtuzumab (n = 9). Tacrolimus was begun post-transplantation with subsequent lengthening of intervals between doses (spaced weaning). Maintenance immunosuppression, morbidity, graft function, and patient/graft survival were collated. Results: Steroids were added temporarily to treat rejection in two patients (both ATG subgroup) or to treat hemolytic anemia in two others. After 16 to 31 months (mean 22), patient and graft survival was 100% and 94%, respectively. The only graft loss was in a nonweaned noncompliant recipient. In the other 16, serum creatinine was 0.85 ± 0.35 mg/dL and creatinine clearance was 90.8 ± 22.1 mL/1.73 m2. All 16 patients are on monotherapy (15 tacrolimus, one sirolimus), and 14 receive every other day or 3 times per week doses. There were no wound or other infections. Two patients developed insulin-dependent diabetes. Conclusion: The strategy of lymphoid depletion and minimum post-transplant immunosuppression appears safe and effective for pediatric kidney recipients. © 2006 Elsevier Inc. All rights reserved

A Lagerstätte from Australia provides insight into the nature of Miocene mesic ecosystems

Reduced precipitation in the Miocene triggered the geographic contraction of rainforest ecosystems around the world. In Australia, this change was particularly pronounced; mesic rainforest ecosystems that once dominated the landscape transformed into the shrublands, grasslands, and deserts of today. A lack of well-preserved fossils has made it difficult to understand the nature of Australian ecosystems before the aridification. Here, we report on an exceptionally well-preserved rainforest biota from New South Wales, Australia. This Konservat-Lagerstätte hosts a rich diversity of microfossils, plants, insects, spiders, and vertebrate remains preserved in goethite. We document evidence for several species interactions including predation, parasitism, and pollination. The fossils are indicative of an oxbow lake in a mesic rainforest and suggest that rainforest distributions have shifted since the Miocene. The variety of fossils preserved, together with high fidelity of preservation, allows for unprecedented insights into the mesic ecosystems that dominated Australia during the Miocene

Rubisco mutagenesis provides new insight into limitations on photosynthesis and growth in Synechocystis PCC6803

Orthophosphate (Pi) stimulates the activation of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) while paradoxically inhibiting its catalysis. Of three Pi-binding sites, the roles of the 5P- and latch sites have been documented, whereas that of the 1P-site remained unclear. Conserved residues at the 1P-site of Rubisco from the cyanobacterium Synechocystis PCC6803 were substituted and the kinetic properties of the enzyme derivatives and effects on cell photosynthesis and growth were examined. While Pi-stimulated Rubisco activation diminished for enzyme mutants T65A/S and G404A, inhibition of catalysis by Pi remained unchanged. Together with previous studies, the results suggest that all three Pi-binding sites are involved in stimulation of Rubisco activation, whereas only the 5P-site is involved in inhibition of catalysis. While all the mutations reduced the catalytic turnover of Rubisco (Kcat) between 6- and 20-fold, the photosynthesis and growth rates under saturating irradiance and inorganic carbon (Ci) concentrations were only reduced 40–50% (in the T65A/S mutants) or not at all (G404A mutant). Analysis of the mutant cells revealed a 3-fold increase in Rubisco content that partially compensated for the reduced Kcat so that the carboxylation rate per chlorophyll was one-third of that in the wild type. Correlation between the kinetic properties of Rubisco and the photosynthetic rate (Pmax) under saturating irradiance and Ci concentrations indicate that a >60% reduction in Kcat can be tolerated before Pmax in Synechocystsis PCC6803 is affected. These results indicate that the limitation of Rubisco activity on the rate of photosynthesis in Synechocystis is low. Determination of Calvin cycle metabolites revealed that unlike in higher plants, cyanobacterial photosynthesis is constrained by phosphoglycerate reduction probably due to limitation of ATP or NADPH