John Young Noel

John Young Noel, a prominent attorney and Mayor of Savannah for four terms, was born in the City of New York on June 18, 1762 of parents illustrious for pity. He was practicing law in Elizabethtown, New Jersey where he married his wife, Sarah C. (Dennis) Stites, the widow of Richard Stites and the mother of Richard Montgomery Stites. The date of his arrival in Savannah is unknown, but Noel was appointed Judge of the Courts in Upper Georgia prior to 1789 Tax Digest for Chatham County. He was also noted to be the Solicitor General of Georgia in 1794.https://digitalcommons.georgiasouthern.edu/sav-bios-lane/1174/thumbnail.jp

Criminal Law and Procedure

The authors have endeavored to select from the many appellate cases those that have the most significant precedential value. The article also outlines some of the most consequential changes tothe law enacted by the Virginia General Assembly in the areas ofcriminal law and procedure

Coming Back Better: Leveraging Crisis-Response Task Forces to Advance Racial Equity and Worker Justice

As the United States enters its third year of navigating the global Covid-19 pandemic, the coronavirus continues to disrupt the lives of millions of workers and their families. About a quarter of the US workforce—nearly 41 million workers -- experienced at least one spell of unemployment due to the coronavirus. As of February 2022, some 3 million fewer people are employed than before the pandemic. While nearly all workers have been affected, yet these impacts are highly unequal: low-wage workers, Black workers, and other workers of color, particularly women of color, have experienced the greatest health and economic harms. This lop-sided labor market recovery has done little to buoy low-wage workers of color who continue to face heavy burdens in terms of rent debt and childcare access

Apollo command module land impact tests

Full-scale-model and actual spacecraft were impact tested to define the emergency land-landing capability of the Apollo command module. Structural accelerations and strains were recorded on analog instrumentation, and a summary to these data is included. The landing kinematics were obtained from high-speed photography. Photographs of the structural damage caused during the tests are included. Even though extensive damage can be expected, the crew will receive nothing more than minor injuries during the majority of the probable landing conditions

Mine closure of pit lakes as terminal sinks: best available practice when options are limited?

In an arid climate, pit lake evaporation rates can exceed influx rates, causing the lake to function as a hydraulic terminal sink, with water levels in the pit remaining below surrounding groundwater levels. We present case studies from Western Australia for two mines nearing closure. At the first site, modelling indicates that waste dump covers for the potentially acid forming (PAF) material would not be successful over the long term (1,000 years or more). The second site is a case study where PAF management is limited by the current waste rock dump location and suitable cover materials. Pit lake water balance modelling using Goldsim software indicated that both pit lakes would function as hydraulic terminal sinks if not backfilled above long-term equilibrium water levels. Poor water quality will likely develop as evapoconcentration increases contaminant concentrations, providing a potential threat to local wildlife. Even so, the best current opportunity to limit the risk of contaminant migration and protect regional groundwater environments may be to limit backfill and intentionally produce a terminal sink pit lake

Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials.

Current pharmacological therapies for heart failure with reduced ejection fraction are largely either repurposed anti-hypertensives that blunt overactivation of the neurohormonal system or diuretics that decrease congestion. However, they do not address the symptoms of heart failure that result from reductions in cardiac output and reserve. Over the last few decades, numerous attempts have been made to develop and test positive cardiac inotropes that improve cardiac haemodynamics. However, definitive clinical trials have failed to show a survival benefit. As a result, no positive inotrope is currently approved for long-term use in heart failure. The focus of this state-of-the-art review is to revisit prior clinical trials and to understand the causes for their findings. Using the learnings from those experiences, we propose a framework for future trials of such agents that maximizes their potential for success. This includes enriching the trials with patients who are most likely to derive benefit, using biomarkers and imaging in trial design and execution, evaluating efficacy based on a wider range of intermediate phenotypes, and collecting detailed data on functional status and quality of life. With a rapidly growing population of patients with advanced heart failure, the epidemiologic insignificance of heart transplantation as a therapeutic intervention, and both the cost and morbidity associated with ventricular assist devices, there is an enormous potential for positive inotropic therapies to impact the outcomes that matter most to patients