1,237 research outputs found
The Vehicle, 1961, Vol. 3 no. 2
Vol. 3, No. 2
Table of Contents
The Voting CattleLinda Kay Campbellpage 5
But For the Passage of TimeDon Shepardsonpage 14
LoveJon Woodspage 16
Infinite JourneyJames E. Martinpage 19
The Clover ChainRichard W. Blairpage 20
SnowballSusan Daughertypage 24
Sureness Is NeverDon Shepardsonpage 26
ConceptionChristine McCollpage 34
Comedy: Relief and GriefTom McPeakpage 35
The Unspoken WordChristine McCollpage 35
CharmBenjamin Polkpage 36
Screaming SpiderTom McPeakpage 39
Just Once in an Early SpringE.J.B.page 39
HummingbirdPauline B. Smithpage 40
Willow TreesPauline B. Smithpage 40
MaturityChristine McCollpage 41
The New YearLinda Campbellpage 41
The StormMary-Jean Pitratpage 42
Ebony IvoryJean Danenbargerpage 42
The Fireball MailAllen Engelbrightpage 43
ExpectationChristine McCollpage 44
CatastropheChristine McCollpage 44
SophisticationBenjamin Polkpage 45
On Playing BridgeMyrna Jo Handleypage 46
SonnetMignon Stricklandpage 48https://thekeep.eiu.edu/vehicle/1009/thumbnail.jp
The Vehicle, 1961, Vol. 3 no. 2
Vol. 3, No. 2
Table of Contents
The Voting CattleLinda Kay Campbellpage 5
But For the Passage of TimeDon Shepardsonpage 14
LoveJon Woodspage 16
Infinite JourneyJames E. Martinpage 19
The Clover ChainRichard W. Blairpage 20
SnowballSusan Daughertypage 24
Sureness Is NeverDon Shepardsonpage 26
ConceptionChristine McCollpage 34
Comedy: Relief and GriefTom McPeakpage 35
The Unspoken WordChristine McCollpage 35
CharmBenjamin Polkpage 36
Screaming SpiderTom McPeakpage 39
Just Once in an Early SpringE.J.B.page 39
HummingbirdPauline B. Smithpage 40
Willow TreesPauline B. Smithpage 40
MaturityChristine McCollpage 41
The New YearLinda Campbellpage 41
The StormMary-Jean Pitratpage 42
Ebony IvoryJean Danenbargerpage 42
The Fireball MailAllen Engelbrightpage 43
ExpectationChristine McCollpage 44
CatastropheChristine McCollpage 44
SophisticationBenjamin Polkpage 45
On Playing BridgeMyrna Jo Handleypage 46
SonnetMignon Stricklandpage 48https://thekeep.eiu.edu/vehicle/1009/thumbnail.jp
Improving response rates using a monetary incentive for patient completion of questionnaires: an observational study
Background: Poor response rates to postal questionnaires can introduce bias and reduce the statistical power of a study. To improve response rates in our trial in primary care we tested the effect of introducing an unconditional direct payment of 5 pound for the completion of postal questionnaires. Methods: We recruited patients in general practice with knee problems from sites across the United Kingdom. An evidence-based strategy was used to follow-up patients at twelve months with postal questionnaires. This included an unconditional direct payment of 5 pound to patients for the completion and return of questionnaires. The first 105 patients did not receive the 5 pound incentive, but the subsequent 442 patients did. We used logistic regression to analyse the effect of introducing a monetary incentive to increase the response to postal questionnaires. Results: The response rate following reminders for the historical controls was 78.1% ( 82 of 105) compared with 88.0% ( 389 of 442) for those patients who received the 5 pound payment (diff = 9.9%, 95% CI 2.3% to 19.1%). Direct payments significantly increased the odds of response ( adjusted odds ratio = 2.2, 95% CI 1.2 to 4.0, P = 0.009) with only 12 of 442 patients declining the payment. The incentive did not save costs to the trial - the extra cost per additional respondent was almost 50 pound. Conclusion: The direct payment of 5 pound significantly increased the completion of postal questionnaires at negligible increase in cost for an adequately powered study
The Vehicle, 1962, Vol. 4
Vol. 4
Table of Contents
The SearchLarry Pricepage 7
If We Should MeetPauline B. Smithpage 16
Sonnet No. 1Linda Campbellpage 17
SnowflakesPauline B. Smithpage 17
Encounter in the VoidEric Crookspage 18
symbolBen Polkpage 24
The Sound of SilenceJames Wilhelmpage 24
ColoursJean Ellen Danenbargerpage 26
vegetableBen Polkpage 27
The GiftJan Holstlawpage 29
The Tiled OvenRichard Glassonpage 30
This Lover Ever WeepsBen Polkpage 31
El DoradoPauline B. Smithpage 32
I\u27m SorryMary Jean Pitratpage 32
The WalkDavid Schwarzpage 33
The Twenty-Third ChannelBen Polkpage 34
After the PicnicLinda Campbellpage 35
SoliloquyJanice Brookspage 35
JulieMyra Edmanpage 36
Poems (1) (2)Gale Crousepage 40
Boardwalk at NightSheran Broadwaypage 41
SunsetPauline B. Smithpage 42
SummerC.E.M.page 42
It\u27s Spring AgainJanice Brookspage 43
Chinese SymbolsJean Ellen Danenbargerpage 43
Why Do You Wait?Gale Crousepage 44
seekerBen Polkpage 46
Poems (3) (4) (5)Gale Crousepage 47
Opposite AttractionsC.E.M.page 48
Illustrations for the winning short story and poemDouglas Koertgehttps://thekeep.eiu.edu/vehicle/1010/thumbnail.jp
Protocol for the Smoking, Nicotine and Pregnancy (SNAP) trial: double-blind, placebo-randomised, controlled trial of nicotine replacement therapy in pregnancy
Background: Smoking in pregnancy remains a public health challenge. Nicotine replacement therapy (NRT) is effective for smoking cessation in non-pregnant people, but because women metabolise nicotine and cotinine much faster in pregnancy, it is unclear whether this will be effective for smoking cessation in pregnancy. The NHS Health Technology Assessment Programme (HTA)-funded smoking, nicotine and pregnancy ( SNAP) trial will investigate whether or not nicotine replacement therapy ( NRT) is effective, cost-effective and safe when used for smoking cessation by pregnant women. Methods/Design: Over two years, in 5 trial centres, 1050 pregnant women who are between 12 and 24 weeks pregnant will be randomised as they attend hospital for ante-natal ultrasound scans. Women will receive either nicotine or placebo transdermal patches with behavioural support. The primary outcome measure is biochemically-validated, self-reported, prolonged and total abstinence from smoking between a quit date ( defined before randomisation and set within two weeks of this) and delivery. At six months after childbirth self-reported maternal smoking status will be ascertained and two years after childbirth, self-reported maternal smoking status and the behaviour, cognitive development and respiratory symptoms of children born in the trial will be compared in both groups. Discussion: This trial is designed to ascertain whether or not standard doses of NRT ( as transdermal patches) are effective and safe when used for smoking cessation during pregnancy
The Vehicle, Spring 1993
1993 Commemorative Edition: Celebrating 35 Years
Table of Contents
The Vehicle Editors\u27 Lineagepage 5
Milestonespage 6
THE SIXTIES
Coverspage 7
Editors\u27 Notespage 8
Sureness is Never - excerptDon Shepardsonpage 9
SophisticationBenjamin Polkpage 10
A SonnetMignon Stricklandpage 11
The Twenty-Third ChannelBen Polkpage 11
Opposite AttractionsC.E.M. (Christine McColl)page 12
John F. KennedyJoel E. Hendrickspage 13
The Girl on the White PonyLarry Gatespage 14
The TimesW.D.M. (William Moser)page 16
Home ThoughtsJane Careypage 17
1966Roger Zulaufpage 18
Nagging ThoughtJanet Andrewspage 18
THE SEVENTIES
Coverspage 19
Editors\u27 Notespage 20
RevolutionsSteve Siegelpage 21
UntitledKristine Kirkhampage 23
The Arithmetic ProblemJanice Forbuspage 23
Willie Seeverson Threw a Worm at MeMary Pipekpage 24
a love poem (by approximation)Ted Baldwinpage 25
Night and Summer in Two WorldsBarry Smithpage 26
Story of a Teenage PickleTerry Louis Schultzpage 27
Danny Lonely, Danny WildDevin Brownpage 28
Always TomorrowMary McDanielpage 29
THE EIGHTIES
Coverspage 31
Having ChildrenDevon Flesorpage 33
What is Unnatural Is Sometimes MagicAngelique Jenningspage 34
If My Father Were A Writer, He Would Still BuildAngelique Jenningspage 35
Photo AlbumPatrick Peterspage 36
Poet Born in Pearl HarborAngelique Jenningspage 37
The History of High School BasketballPatrick Peterspage 38
Banana BreadGail Bowerpage 39
Cover LetterBob Zordanipage 40
Home MoviesBob Zordanipage 41
MigrationPatrick Peterspage 42
THE NINETIES
Ba, Ba, Black SheepVictoria Bennettpage 45
Daily LessonsJennifer Moropage 49
Folding My OwnLaurie Ann Malispage 51
About the Authorspage 53
Editors\u27 Notespage 56https://thekeep.eiu.edu/vehicle/1062/thumbnail.jp
The Vehicle, Spring 1993
1993 Commemorative Edition: Celebrating 35 Years
Table of Contents
The Vehicle Editors\u27 Lineagepage 5
Milestonespage 6
THE SIXTIES
Coverspage 7
Editors\u27 Notespage 8
Sureness is Never - excerptDon Shepardsonpage 9
SophisticationBenjamin Polkpage 10
A SonnetMignon Stricklandpage 11
The Twenty-Third ChannelBen Polkpage 11
Opposite AttractionsC.E.M. (Christine McColl)page 12
John F. KennedyJoel E. Hendrickspage 13
The Girl on the White PonyLarry Gatespage 14
The TimesW.D.M. (William Moser)page 16
Home ThoughtsJane Careypage 17
1966Roger Zulaufpage 18
Nagging ThoughtJanet Andrewspage 18
THE SEVENTIES
Coverspage 19
Editors\u27 Notespage 20
RevolutionsSteve Siegelpage 21
UntitledKristine Kirkhampage 23
The Arithmetic ProblemJanice Forbuspage 23
Willie Seeverson Threw a Worm at MeMary Pipekpage 24
a love poem (by approximation)Ted Baldwinpage 25
Night and Summer in Two WorldsBarry Smithpage 26
Story of a Teenage PickleTerry Louis Schultzpage 27
Danny Lonely, Danny WildDevin Brownpage 28
Always TomorrowMary McDanielpage 29
THE EIGHTIES
Coverspage 31
Having ChildrenDevon Flesorpage 33
What is Unnatural Is Sometimes MagicAngelique Jenningspage 34
If My Father Were A Writer, He Would Still BuildAngelique Jenningspage 35
Photo AlbumPatrick Peterspage 36
Poet Born in Pearl HarborAngelique Jenningspage 37
The History of High School BasketballPatrick Peterspage 38
Banana BreadGail Bowerpage 39
Cover LetterBob Zordanipage 40
Home MoviesBob Zordanipage 41
MigrationPatrick Peterspage 42
THE NINETIES
Ba, Ba, Black SheepVictoria Bennettpage 45
Daily LessonsJennifer Moropage 49
Folding My OwnLaurie Ann Malispage 51
About the Authorspage 53
Editors\u27 Notespage 56https://thekeep.eiu.edu/vehicle/1062/thumbnail.jp
The Vehicle, 1963, Vol. 5
Vol. 5
Table of Contents
Milepostspage 3
Rhyme Conceived At DawnDaun Alan Leggpage 4
NightRoss Kokospage 4
UncrownedOra Blanche T. Kingpage 4
SunfishingL.J.G.page 5
The Man Who Went To New YorkEric Crookspage 7
The DreamPauline B. Smithpage 18
Open WindowsDavid Helmpage 19
SalvationChristine McCollpage 19
The Chess GamePierre Hooverpage 20
CataclysmRaymond Kapraunpage 20
A Microscopic ViewKenneth L. Vadovskypage 21
See How Love ComesLiz Puckettpage 21
A Can Of Beer For AndyKenneth L. Vadovskypage 22
A MonsterDixie Lee Motleypage 28
InconstancyJanice Brookspage 29
DreamerDaun Alan Leggpage 29
The Third WishGlenda Vursellpage 30
The MiracleJanice Brookspage 32
What Lives Where Love Once Dwelt?Vernell Vyvialpage 33
The Most Unforgettable Person I Have Ever KnownJames Flingpage 34
Winter ThoughtsPauline B. Smithpage 35
A Winter NightPeggy Lambertpage 35
The Silver WhaleL.J.G.page 36
RaindropsDixie Lee Motleypage 40
Conflict Of Soul IJean Konzelmanpage 40
JudyChristine McCollpage 41
Sadness No. 3 (Vergessen)Sherry Sue Frypage 41
Lost GoldLarry Pricepage 42
EchoesCharles Cooleypage 48
TruthDaun Alan Leggpage 48
SunsetCarol Bennettpage 48
Cover designTom Windsor
Illustration for winning storyJoel E. Hendrickshttps://thekeep.eiu.edu/vehicle/1011/thumbnail.jp
Stem cell-derived porcine macrophages as a new platform for studying host-pathogen interactions
BACKGROUND: Infectious diseases of farmed and wild animals pose a recurrent threat to food security and human health. The macrophage, a key component of the innate immune system, is the first line of defence against many infectious agents and plays a major role in shaping the adaptive immune response. However, this phagocyte is a target and host for many pathogens. Understanding the molecular basis of interactions between macrophages and pathogens is therefore crucial for the development of effective strategies to combat important infectious diseases. RESULTS: We explored how porcine pluripotent stem cells (PSCs) can provide a limitless in vitro supply of genetically and experimentally tractable macrophages. Porcine PSC-derived macrophages (PSCdMs) exhibited molecular and functional characteristics of ex vivo primary macrophages and were productively infected by pig pathogens, including porcine reproductive and respiratory syndrome virus (PRRSV) and African swine fever virus (ASFV), two of the most economically important and devastating viruses in pig farming. Moreover, porcine PSCdMs were readily amenable to genetic modification by CRISPR/Cas9 gene editing applied either in parental stem cells or directly in the macrophages by lentiviral vector transduction. CONCLUSIONS: We show that porcine PSCdMs exhibit key macrophage characteristics, including infection by a range of commercially relevant pig pathogens. In addition, genetic engineering of PSCs and PSCdMs affords new opportunities for functional analysis of macrophage biology in an important livestock species. PSCs and differentiated derivatives should therefore represent a useful and ethical experimental platform to investigate the genetic and molecular basis of host-pathogen interactions in pigs, and also have wider applications in livestock. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12915-021-01217-8
European code against cancer 4th edition: 12 ways to reduce your cancer risk
This overview describes the principles of the 4th edition of the European Code against Cancer and provides an introduction to the 12 recommendations to reduce cancer risk. Among the 504.6 million inhabitants of the member states of the European Union (EU28), there are annually 2.64 million new cancer cases and 1.28 million deaths from cancer. It is estimated that this cancer burden could be reduced by up to one half if scientific knowledge on causes of cancer could be translated into successful prevention. The Code is a preventive tool aimed to reduce the cancer burden by informing people how to avoid or reduce carcinogenic exposures, adopt behaviours to reduce the cancer risk, or to participate in organised intervention programmes. The Code should also form a base to guide national health policies in cancer prevention. The 12 recommendations are: not smoking or using other tobacco products; avoiding second-hand smoke; being a healthy body weight; encouraging physical activity; having a healthy diet; limiting alcohol consumption, with not drinking alcohol being better for cancer prevention; avoiding too much exposure to ultraviolet radiation; avoiding cancer-causing agents at the workplace; reducing exposure to high levels of radon; encouraging breastfeeding; limiting the use of hormone replacement therapy; participating in organised vaccination programmes against hepatitis B for newborns and human papillomavirus for girls; and participating in organised screening programmes for bowel cancer, breast cancer, and cervical cancer
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