Preparation of monotectic alloys having a controlled microstructure by directional solidification under dopant-induced interface breakdown

Monotectic alloys having aligned spherical particles of rods of the minor component dispersed in a matrix of the major component are prepared by forming a melt containing predetermined amounts of the major and minor components of a chosen monotectic system, providing in the melt a dopant capable of breaking down the liquid solid interface for the chosen alloy, and directionally solidfying the melt at a selected temperature gradient and a selected rate of movement of the liquid-solid interface (growth rate). Shaping of the minor component into spheres or rods and the spacing between them are controlled by the amount of dopant and the temperature gradient and growth rate values. Specific alloy systems include Al Bi, Al Pb and Zn Bi, using a transition element such as iron

The localization sequence for the algebraic K-theory of topological K-theory

We prove a conjecture of Rognes by establishing a localization cofiber sequence of spectra, K(Z) to K(ku) to K(KU) to Sigma K(Z), for the algebraic K-theory of topological K-theory. We deduce the existence of this sequence as a consequence of a devissage theorem identifying the K-theory of the Waldhausen category of Postnikov towers of modules over a connective A-infinity ring spectrum R with the Quillen K-theory of the abelian category of finitely generated pi_0(R)-modules.Comment: Updated final version. Small change in definition of S' construction and correction to the proof of 2.

A generalization of Hausdorff dimension applied to Hilbert cubes and Wasserstein spaces

A Wasserstein spaces is a metric space of sufficiently concentrated probability measures over a general metric space. The main goal of this paper is to estimate the largeness of Wasserstein spaces, in a sense to be precised. In a first part, we generalize the Hausdorff dimension by defining a family of bi-Lipschitz invariants, called critical parameters, that measure largeness for infinite-dimensional metric spaces. Basic properties of these invariants are given, and they are estimated for a naturel set of spaces generalizing the usual Hilbert cube. In a second part, we estimate the value of these new invariants in the case of some Wasserstein spaces, as well as the dynamical complexity of push-forward maps. The lower bounds rely on several embedding results; for example we provide bi-Lipschitz embeddings of all powers of any space inside its Wasserstein space, with uniform bound and we prove that the Wasserstein space of a d-manifold has "power-exponential" critical parameter equal to d.Comment: v2 Largely expanded version, as reflected by the change of title; all part I on generalized Hausdorff dimension is new, as well as the embedding of Hilbert cubes into Wasserstein spaces. v3 modified according to the referee final remarks ; to appear in Journal of Topology and Analysi

Rapid and efficient stable gene transfer to mesenchymal stromal cells using a modified foamy virus vector

Mesenchymal stromal cells (MSCs) hold great promise for regenerative medicine. Stable ex vivo gene transfer to MSCs could improve the outcome and scope of MSC therapy, but current vectors require multiple rounds of transduction, involve genotoxic viral promoters and/or the addition of cytotoxic cationic polymers in order to achieve efficient transduction. We describe a self-inactivating foamy virus vector (FVV), incorporating the simian macaque foamy virus envelope and using physiological promoters, which efficiently transduces murine MSCs (mMSCs) in a single-round. High and sustained expression of the transgene, whether GFP or the lysosomal enzyme, arylsulphatase A (ARSA), was achieved. Defining MSC characteristics (surface marker expression and differentiation potential), as well as long-term engraftment and distribution in the murine brain following intracerebroventricular delivery, are unaffected by FVV transduction. Similarly, greater than 95% of human MSCs (hMSCs) were stably transduced using the same vector, facilitating human application. This work describes the best stable gene transfer vector available for mMSCs and hMSCs

The Kinematic Properties of the Extended Disks of Spiral Galaxies: A Sample of Edge-On Galaxies

We present a kinematic study of the outer regions (R_25<R<2 R_25) of 17 edge-on disk galaxies. Using deep long-slit spectroscopy (flux sensitivity a few 10^-19 erg s^-1 cm^-2 arcsec^-2), we search for H-alpha emission, which must be emitted at these flux levels by any accumulation of hydrogen due to the presence of the extragalactic UV background and any other, local source of UV flux. We present results from the individual galaxy spectra and a stacked composite. We detect H-alpha in many cases well beyond R_25 and sometimes as far as 2 R_25. The combination of sensitivity, spatial resolution, and kinematic resolution of this technique thus provides a powerful complement to 21-cm observations. Kinematics in the outer disk are generally disk-like (flat rotation curves, small velocity dispersions) at all radii, and there is no evidence for a change in the velocity dispersion with radius. We place strong limits, few percent, on the existence of counter-rotating gas out to 1.5 R_25. These results suggest that thin disks extend well beyond R_25; however, we also find a few puzzling anomalies. In ESO 323-G033 we find two emission regions that have velocities close to the systemic velocity rather than the expected rotation velocity. These low relative velocities are unlikely to be simply due to projection effects and so suggest that these regions are not on disk-plane, circular orbits. In MCG-01-31-002 we find emission from gas with a large velocity dispersion that is co-rotating with the inner disk.Comment: 18 pages, 14 figures, accepted for publication in Ap

Noise Correlations in a Coulomb Blockaded Quantum Dot

We report measurements of current noise auto- and cross-correlation in a tunable quantum dot with two or three leads. As the Coulomb blockade is lifted at finite source-drain bias, the auto-correlation evolves from super-Poissonian to sub-Poissonian in the two-lead case, and the cross-correlation evolves from positive to negative in the three-lead case, consistent with transport through multiple levels. Cross-correlations in the three-lead dot are found to be proportional to the noise in excess of the Poissonian value in the limit of weak output tunneling

Self-control in decision-making involves modulation of the vmPFC valuation system

Every day, individuals make dozens of choices between an alternative with higher overall value and a more tempting but ultimately inferior option. Optimal decision-making requires self-control. We propose two hypotheses about the neurobiology of self-control: (i) Goal-directed decisions have their basis in a common value signal encoded in ventromedial prefrontal cortex (vmPFC), and (ii) exercising self-control involves the modulation of this value signal by dorsolateral prefrontal cortex (DLPFC). We used functional magnetic resonance imaging to monitor brain activity while dieters engaged in real decisions about food consumption. Activity in vmPFC was correlated with goal values regardless of the amount of self-control. It incorporated both taste and health in self-controllers but only taste in non–self-controllers. Activity in DLPFC increased when subjects exercised self-control and correlated with activity in vmPFC