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Attributes of Society of Genitourinary Reconstructive Surgeons Fellows and Early Career Trajectory of the Recent Graduates
Slow relaxation of conductance of amorphous hopping insulators
We discuss memory effects in the conductance of hopping insulators due to
slow rearrangements of structural defects leading to formation of polarons
close to the electron hopping states. An abrupt change in the gate voltage and
corresponding shift of the chemical potential change populations of the hopping
sites, which then slowly relax due to rearrangements of structural defects. As
a result, the density of hopping states becomes time dependent on a scale
relevant to rearrangement of the structural defects leading to the excess time
dependent conductivity.Comment: 6 pages, 1 figur
Searching for keV Sterile Neutrino Dark Matter with X-ray Microcalorimeter Sounding Rockets
High-resolution X-ray spectrometers onboard suborbital sounding rockets can
search for dark matter candidates that produce X-ray lines, such as decaying
keV-scale sterile neutrinos. Even with exposure times and effective areas far
smaller than XMM-Newton and Chandra observations, high-resolution, wide
field-of-view observations with sounding rockets have competitive sensitivity
to decaying sterile neutrinos. We analyze a subset of the 2011 observation by
the X-ray Quantum Calorimeter instrument centered on Galactic coordinates l =
165, b = -5 with an effective exposure of 106 seconds, obtaining a limit on the
sterile neutrino mixing angle of sin^2(2 theta) < 7.2e-10 at 95% CL for a 7 keV
neutrino. Better sensitivity at the level of sin^2(2 theta) ~ 2.1e-11 at 95\%
CL for a 7 keV neutrino is achievable with future 300-second observations of
the galactic center by the Micro-X instrument, providing a definitive test of
the sterile neutrino interpretation of the reported 3.56 keV excess from galaxy
clusters.Comment: 13 pages, 13 figures, submitted to Ap
Observed Limits on Charge Exchange Contributions to the Diffuse X-ray Background
We present a high resolution spectrum of the diffuse X-ray background from
0.1 to 1 keV for a ~1 region of the sky centered at l=90, b=+60 using a
36-pixel array of microcalorimeters flown on a sounding rocket. With an energy
resolution of 11 eV FWHM below 1 keV, the spectrum's observed line ratios help
separate charge exchange contributions originating within the heliosphere from
thermal emission of hot gas in the interstellar medium. The X-ray sensitivity
below 1 keV was reduced by about a factor of four from contamination that
occurred early in the flight, limiting the significance of the results. The
observed centroid of helium-like O VII is 568+2-3 eV at 90% confidence. Since
the centroid expected for thermal emission is 568.4 eV while for charge
exchange is 564.2 eV, thermal emission appears to dominate for this line
complex, consistent with much of the high-latitude O VII emission originating
in 2-3 x 10^6 K gas in the Galactic halo. On the other hand, the observed ratio
of C VI Ly gamma to Ly alpha is 0.3+-0.2. The expected ratios are 0.04 for
thermal emission and 0.24 for charge exchange, indicating that charge exchange
must contribute strongly to this line and therefore potentially to the rest of
the ROSAT R12 band usually associated with 10^6 K emission from the Local Hot
Bubble. The limited statistics of this experiment and systematic uncertainties
due to the contamination require only >32% thermal emission for O VII and >20%
from charge exchange for C VI at the 90% confidence level. An experimental gold
coating on the silicon substrate of the array greatly reduced extraneous
signals induced on nearby pixels from cosmic rays passing through the
substrate, reducing the triggered event rate by a factor of 15 from a previous
flight of the instrument.Comment: 14 pages, 7 figures, to be published in Ap
A network model to investigate structural and electrical properties of proteins
One of the main trend in to date research and development is the
miniaturization of electronic devices. In this perspective, integrated
nanodevices based on proteins or biomolecules are attracting a major interest.
In fact, it has been shown that proteins like bacteriorhodopsin and azurin,
manifest electrical properties which are promising for the development of
active components in the field of molecular electronics. Here we focus on two
relevant kinds of proteins: The bovine rhodopsin, prototype of GPCR protein,
and the enzyme acetylcholinesterase (AChE), whose inhibition is one of the most
qualified treatments of Alzheimer disease. Both these proteins exert their
functioning starting with a conformational change of their native structure.
Our guess is that such a change should be accompanied with a detectable
variation of their electrical properties. To investigate this conjecture, we
present an impedance network model of proteins, able to estimate the different
electrical response associated with the different configurations. The model
resolution of the electrical response is found able to monitor the structure
and the conformational change of the given protein. In this respect, rhodopsin
exhibits a better differential response than AChE. This result gives room to
different interpretations of the degree of conformational change and in
particular supports a recent hypothesis on the existence of a mixed state
already in the native configuration of the protein.Comment: 25 pages, 12 figure
The Implementation of the Colored Abstract Simplicial Complex and its Application to Mesh Generation
We introduce CASC: a new, modern, and header-only C++ library which provides
a data structure to represent arbitrary dimension abstract simplicial complexes
(ASC) with user-defined classes stored directly on the simplices at each
dimension. This is accomplished by using the latest C++ language features
including variadic template parameters introduced in C++11 and automatic
function return type deduction from C++14. Effectively CASC decouples the
representation of the topology from the interactions of user data. We present
the innovations and design principles of the data structure and related
algorithms. This includes a metadata aware decimation algorithm which is
general for collapsing simplices of any dimension. We also present an example
application of this library to represent an orientable surface mesh.Comment: 24 pages, 6 figure
The thermal equation of state of FeTiO_3 ilmenite based on in situ X-ray diffraction at high pressures and temperatures
We present in situ measurements of the unit-cell volume of a natural terrestrial ilmenite (Jagersfontein mine, South Africa) and a synthetic reduced ilmenite (FeTiO_3) at simultaneous high pressure and high temperature up to 16 GPa and 1273 K. Unit-cell volumes were determined using energy-dispersive synchrotron X-ray diffraction in a multi-anvil press. Mössbauer analyses show that the synthetic sample contained insignificant amounts of Fe^(3+) both before and after the experiment. Results were fit to Birch-Murnaghan thermal equations of state, which reproduce the experimental data to within 0.5 and 0.7 GPa for the synthetic and natural samples, respectively. At ambient conditions, the unit-cell volume of the natural sample [V_0 = 314.75 ± 0.23 (1 ) Å^3] is significantly smaller than that of the synthetic sample [V_0 = 319.12 ± 0.26 Å^3]. The difference can be attributed to the presence of impurities and Fe^(3+) in the natural sample. The 1 bar isothermal bulk moduli K_(T0) for the reduced ilmenite is slightly larger than for the natural ilmenite (181 ± 7 and 165 ± 6 GPa, respectively), with pressure derivatives K_0' = 3 ± 1. Our results, combined with literature data, suggest that the unit-cell volume of reduced ilmenite is significantly larger than that of oxidized ilmenite, whereas their thermoelastic parameters are similar. Our data provide more appropriate input parameters for thermo-chemical models of lunar interior evolution, in which reduced ilmenite plays a critical role
Influence of conformational fluctuations on enzymatic activity: modelling the functional motion of beta-secretase
Considerable insight into the functional activity of proteins and enzymes can
be obtained by studying the low-energy conformational distortions that the
biopolymer can sustain. We carry out the characterization of these large scale
structural changes for a protein of considerable pharmaceutical interest, the
human -secretase. Starting from the crystallographic structure of the
protein, we use the recently introduced beta-Gaussian model to identify, with
negligible computational expenditure, the most significant distortion occurring
in thermal equilibrium and the associated time scales. The application of this
strategy allows to gain considerable insight into the putative functional
movements and, furthermore, helps to identify a handful of key regions in the
protein which have an important mechanical influence on the enzymatic activity
despite being spatially distant from the active site. The results obtained
within the Gaussian model are validated through an extensive comparison against
an all-atom Molecular Dynamics simulation.Comment: To be published in a special issue of J. Phys.: Cond. Mat. (Bedlewo
Workshop
Importance of correlation effects in hcp iron revealed by a pressure-induced electronic topological transition
We discover that hcp phases of Fe and Fe0.9Ni0.1 undergo an electronic
topological transition at pressures of about 40 GPa. This topological change of
the Fermi surface manifests itself through anomalous behavior of the Debye
sound velocity, c/a lattice parameter ratio and M\"ossbauer center shift
observed in our experiments. First-principles simulations within the dynamic
mean field approach demonstrate that the transition is induced by many-electron
effects. It is absent in one-electron calculations and represents a clear
signature of correlation effects in hcp Fe
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