Ranking of Fatigue Data Based upon Monte Carlo Simulated Confidence Number Figures

Since fatigue is probabilistic, trends observed in large populations of data are necessary to select materials, compare engineering designs, or establish preventative maintenance schedules. The generation of large experimental fatigue populations, however, is prohibitively time consuming and costly. As a solution a Weibull-based Monte Carlo simulation of fatigue life was developed based upon a failed bin model, and five billion fatigue lives were simulated. These fatigue lives were used to generate L10 lives. A model of confidence number was developed dependent upon statistically large samples of simulated L10 fatigue lives, and independent of a limited number of published curves. Using these simulated values, Confidence number figures were generated that deviated from 0.0% - 7.4% of previously published figures and were independent of confidence bands. Results differed as little as 1% from those determined graphically for experimental bearing data sets while graphical interpolation was eliminated

Measured Thoracic Gas Volume Versus Two Predictions

Body composition, or one’s fat mass relative to total mass, is important to a person’s health and physical performance. One method to measure body composition is the Bod Pod air displacement plethysmograph. To determine body volume from the Bod Pod, thoracic gas volume (TGV), or the volume of air in the lungs during a normal breath, must be measured or predicted. PURPOSE: The intent of this study was to compare measured TGV to two predictions: one from the Bod Pod (TGVBP) that makes assumptions about functional residual capacity and tidal volume, and one from a recent publication (TGVDucharme) that relies on measures of height and body mass rather than lung volumes. METHODS: Bod Pod data from university club sport athletes participating in a larger study were used. TGV was measured following the Bod Pod manufacturer’s instructions. Comparisons of mean data were made between the measured test and the two predictions with a one-way repeated-measures ANOVA. Individual error scores were evaluated with Bland-Altman plots. RESULTS: Data from 26 club sport athletes (18 male, 8 female) revealed a statistically significant difference (p = .001) between the three TGV measures. The measured TGV (4.108 ± 0.850 L) and TGVDucharme (4.092 ± 0.655 L) were not significantly different from one another (p = .851), but TGVBP (3.724 ± 0.409 L) significantly underestimated the measured TGV (p = .002) and Ducharme’s prediction (p \u3c .001). A clear bias exists for TGVBP (r = -0.799, p \u3c .001), such that the Bod Pod prediction overestimates athletes with a small TGV (\u3c 3.3 L) and underestimates athletes with a large TGV (\u3e 3.3 L). The bias for TGVDucharme is statistically significant (r = -0.460, p = .018), but much smaller than the bias from the Bod Pod prediction. CONCLUSION: When possible, measure TGV. If TGV must be predicted, use the Ducharme prediction rather than the TGV prediction from the Bod Pod

Health care system collaboration to address chronic diseases: A nationwide snapshot from state public health practitioners

INTRODUCTION: Until recently, health care systems in the United States often lacked a unified approach to prevent and manage chronic disease. Recent efforts have been made to close this gap through various calls for increased collaboration between public health and health care systems to better coordinate provision of services and programs. Currently, the extent to which the public health workforce has responded is relatively unknown. The objective of this study is to explore health care system collaboration efforts and activities among a population-based sample of state public health practitioners. METHODS: During spring 2013, a national survey was administered to state-level chronic disease public health practitioners. Respondents were asked to indicate whether or not they collaborate with health care systems. Those who reported “yes” were asked to indicate all topic areas in which they collaborate and provide qualitative examples of their collaborative work. RESULTS: A total of 759 respondents (84%) reported collaboration. Common topics of collaboration activities were tobacco, cardiovascular health, and cancer screening. More client-oriented interventions than system-wide interventions were found in the qualitative examples provided. Respondents who collaborated were also more likely to use the Community Guide, use evidence-based decision making, and work in program areas that involved secondary, rather than primary, prevention. CONCLUSION: The study findings indicate a need for greater guidance on collaboration efforts that involve system-wide and cross-system interventions. Tools such as the Community Guide and evidence-based training courses may be useful in providing such guidance

Closing critical gaps to enable a circular plastics economy

Global Petrochemicals and AIChE requested the design, optimization, and economic evaluation of a PyOil purification plant and recommendations for improvement of a sorting facility in Bali as well as recommendations to increase participation in waste management in the region.The design of the PyOil purification plant had two major sections: A fractionation section of the plant where PyOil feed would be split into PyGas, a Light Cut, a Medium Cut, Barge Oil, and potential coking products; and a purification section of the plant where the Light Cut and Medium Cut would have contaminants removed. The Light Cut and Medium Cut products will be utilized as feed for a steam cracker in an ethylene plant, the PyGas as fuel gas in the ethylene plant, and the Heavy Cut split into two products for the sake of creating new profitability for the process. The plant was designed to operate continuously and was designed with spare equipment so that production upsets would not stop production of products or cause off specification production. Overall, the design was evaluated to cost $19.6 million in capital cost,$1.99 million per year in variable cost, and $4.35 million per year in fixed cost.When looking at how to improve the sorting facility and community involvement, three critical gaps were sought to be closed with possible new solutions which would also take steps toward solving the plastic waste issue. It was sought to close gaps in Quality, Quantity, and Affordability with recyclable waste collection process in Bali. To solve the quality gap, a three-bag system would be introduced to shift sorting responsibility from the waste collection company to the households. With an increase in the quality of waste sorting, the quantity gap would close as a greater separation of waste entering the waste facilities would also mean that the facility would be capable of greater throughput of recycled products. The quantity gap would also be closed with a cooperative program to encourage households to recycle more often because of an incentive system that would compensate participating households at the end of every year. Both the quality and quantity gap solutions would help close the affordability gap by minimizing cost for waste management facilities in Bali with a lower labor cost per waste delivered

Montmorency cherry juice reduces muscle damage caused by intensive strength exercise.

addresses: Sports and Exercise Science Research Centre, London South Bank University, London, United Kingdom. [email protected]: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov'tThis is a non-final version of an article published in final form in Medicine and Science in Sports and Exercise, 2011, Vol. 43, Issue 8, pp. 1544 – 1551. © 2011 American College of Sports Medicine (ACSM)Montmorency cherries contain high levels of polyphenolic compounds including flavonoids and anthocyanins possessing antioxidant and anti-inflammatory effects. We investigated whether the effects of intensive unilateral leg exercise on oxidative damage and muscle function were attenuated by consumption of a Montmorency cherry juice concentrate using a crossover experimental design

Digital health policy and programs for hospital care in Vietnam: scoping review

Background: There are a host of emergent technologies with the potential to improve hospital care in low- and middle-income countries such as Vietnam. Wearable monitors and artificial intelligence–based decision support systems could be integrated with hospital-based digital health systems such as electronic health records (EHRs) to provide higher level care at a relatively low cost. However, the appropriate and sustainable application of these innovations in low- and middle-income countries requires an understanding of the local government’s requirements and regulations such as technology specifications, cybersecurity, data-sharing protocols, and interoperability. Objective: This scoping review aims to explore the current state of digital health research and the policies that govern the adoption of digital health systems in Vietnamese hospitals. Methods: We conducted a scoping review using a modification of the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines. PubMed and Web of Science were searched for academic publications, and Thư Viện Pháp Luật, a proprietary database of Vietnamese government documents, and the Vietnam Electronic Health Administration website were searched for government documents. Google Scholar and Google Search were used for snowballing searches. The sources were assessed against predefined eligibility criteria through title, abstract, and full-text screening. Relevant information from the included sources was charted and summarized. The review process was primarily undertaken by one researcher and reviewed by another researcher during each step. Results: In total, 11 academic publications and 20 government documents were included in this review. Among the academic studies, 5 reported engineering solutions for information systems in hospitals, 2 assessed readiness for EHR implementation, 1 tested physicians’ performance before and after using clinical decision support software, 1 reported a national laboratory information management system, and 2 reviewed the health system’s capability to implement eHealth and artificial intelligence. Of the 20 government documents, 19 were promulgated from 2013 to 2020. These regulations and guidance cover a wide range of digital health domains, including hospital information management systems, general and interoperability standards, cybersecurity in health organizations, conditions for the provision of health information technology (HIT), electronic health insurance claims, laboratory information systems, HIT maturity, digital health strategies, electronic medical records, EHRs, and eHealth architectural frameworks. Conclusions: Research about hospital-based digital health systems in Vietnam is very limited, particularly implementation studies. Government regulations and guidance for HIT in health care organizations have been released with increasing frequency since 2013, targeting a variety of information systems such as electronic medical records, EHRs, and laboratory information systems. In general, these policies were focused on the basic specifications and standards that digital health systems need to meet. More research is needed in the future to guide the implementation of digital health care systems in the Vietnam hospital setting

Inhibition of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase and Application of Statins as a Novel Effective Therapeutic Approach against Acanthamoeba Infections

Acanthamoeba is an opportunistic pathogen in humans, whose infections most commonly manifest as Acanthamoeba keratitis or, more rarely, granulomatous amoebic encephalitis. Although there are many therapeutic options for the treatment of Acanthamoeba, they are generally lengthy and/or have limited efficacy. Therefore, there is a requirement for the identification, validation, and development of novel therapeutic targets against these pathogens. Recently, RNA interference (RNAi) has been widely used for these validation purposes and has proven to be a powerful tool for Acanthamoeba therapeutics. Ergosterol is one of the major sterols in the membrane of Acanthamoeba. 3-Hydroxy-3-methylglutaryl–coenzyme A (HMG-CoA) reductase is an enzyme that catalyzes the conversion of HMG-CoA to mevalonate, one of the precursors for the production of cholesterol in humans and ergosterol in plants, fungi, and protozoa. Statins are compounds which inhibit this enzyme and so are promising as chemotherapeutics. In order to validate whether this enzyme could be an interesting therapeutic target in Acanthamoeba, small interfering RNAs (siRNAs) against HMG-CoA were developed and used to evaluate the effects induced by the inhibition of Acanthamoeba HMG-CoA. It was found that HMG-CoA is a potential drug target in these pathogenic free-living amoebae, and various statins were evaluated in vitro against three clinical strains of Acanthamoeba by using a colorimetric assay, showing important activities against the tested strains. We conclude that the targeting of HMG-CoA and Acanthamoeba treatment using statins is a novel powerful treatment option against Acanthamoeba species in human disease