Multisite PCET with photocharged carbon nitride in dark

A combination of photochemistry and proton coupled electron transfer (PCET) is a primary strategy employed by biochemical systems and synthetic chemistry to enable uphill reactions under mild conditions. Degenerate nanometer-sized n-type semiconductor nanoparticles (SCNPs) with the Fermi level above the bottom of the conduction band are strongly reducing and act more like metals than semiconductors. Application of the degenerate SCNPs is limited to few examples. Herein, we load microporous potassium poly(heptazine imide) (K-PHI) nanoparticles with electrons (e–) and charge balancing protons (H+) in an illumination phase using sacrificial agents. e–/H+ in the K-PHI nanoparticles are weakly bound and therefore could be used in a range of PCET reactions in dark, such as generation of aryl radicals from aryl halides, ketyl radicals from ketones, and 6e–/6H+ reduction of nitrobenzene to aniline. The integration of several features that until now were intrinsic for plants and natural photosynthesis into a transition metal free nanomaterial composed of abundant elements (C, N, and K) offers a powerful tool for synthetic organic chemistry

Multiple sclerosis treatment and melanoma development

Therapy of multiple sclerosis (MS) with disease-modifying agents such as natalizumab or fingolimod has been associated with the development of cutaneous melanoma. Here we briefly revise literature data and report of a case of a 48-year old woman who developed a melanoma and several atypical naevi after sub sequential treatment with natalizumab (1 year) and fingolimod (7 years). By immunohistochemistry we observed the presence of T cells and leukocyte infiltration as well as of vascular endothelial growth factor (VEGF)-A expression in the patient melanoma biopsy. Then, we analyzed proliferation, migration and VEGF-A expression in three melanoma cell lines and found out that both natalizumab and fingolimod inhibited tumor cell proliferation but promoted or blocked cell migration depending on the cell line examined. VEGF-A secretion was augmented in one melanoma cell line only after fingolimod treatment. In conclusion, our in vitro data do not support the hypothesis of a direct action of natalizumab or fingolimod on melanoma progression but acting on the tumor microenvironment these treatments could indirectly favor melanoma evolution

High-momentum dynamic structure function of liquid 3He-4He mixtures: a microscopic approach

The high-momentum dynamic structure function of liquid 3He-4He mixtures has been studied introducing final state effects. Corrections to the impulse approximation have been included using a generalized Gersch-Rodriguez theory that properly takes into account the Fermi statistics of 3He atoms. The microscopic inputs, as the momentum distributions and the two-body density matrices, correspond to a variational (fermi)-hypernetted chain calculation. The agreement with experimental data obtained at $q=23.1$ \AA$^{-1}$ is not completely satisfactory, the comparison being difficult due to inconsistencies present in the scattering measurements. The significant differences between the experimental determinations of the 4He condensate fraction and the 3He kinetic energy, and the theoretical results, still remain unsolved.Comment: 18 pages, 11 figures, to appear in Phys. Rev.

Reliability assessment of open-source multiscale landslide susceptibility maps and effects of their fusion

Several landslide susceptibility (LS) maps at various scales of analysis have been performed with specific zoning purposes and techniques. Supervised machine learning algorithms (ML) have become one of the most diffused techniques for landslide prediction, whose reliability is firmly based on the quality of input data. Site-specific landslide inventories are often more accurate and complete than national or worldwide databases. For these reasons, detailed landslide inventory and predisposing variables must be collected to derive reliable LS products. However, high-quality data are often rare, and risk managers must consider lower-resolution available products with no more than informative purposes. In this work, we compared different ML models to select the most accurate for large-scale LS assessment within the Municipality of Rome. The ExtraTreesClassifier outperformed the others reaching an average F1-score of 0.896. Thereafter, we addressed the reliability of open-source LS maps at different scales of analysis (global to regional) by means of statistical and spatial analysis. The obtained results shed light on the difference in hazard zoning depending on the scale and mapping unit. An approach for low-resolution LS data fusion was attempted, assessing the importance of the adopted criteria, which increased the ability to detect occurred landslides while maintaining precision

A Logical Verification Methodology for Service-Oriented Computing

We introduce a logical verification methodology for checking behavioural properties of service-oriented computing systems. Service properties are described by means of SocL, a branching-time temporal logic that we have specifically designed to express in an effective way distinctive aspects of services, such as, e.g., acceptance of a request, provision of a response, and correlation among service requests and responses. Our approach allows service properties to be expressed in such a way that they can be independent of service domains and specifications. We show an instantiation of our general methodology that uses the formal language COWS to conveniently specify services and the expressly developed software tool CMC to assist the user in the task of verifying SocL formulae over service specifications. We demonstrate feasibility and effectiveness of our methodology by means of the specification and the analysis of a case study in the automotive domain

Complete Acid Ceramidase ablation prevents cancer-initiating cell formation in melanoma cells

Acid ceramidase (AC) is a lysosomal cysteine hydrolase that catalyzes the conversion of ceramide into fatty acid and sphingosine. This reaction lowers intracellular ceramide levels and concomitantly generates sphingosine used for sphingosine-1-phosphate (S1P) production. Since increases in ceramide and consequent decreases of S1P reduce proliferation of various cancers, AC might offer a new target for anti-tumor therapy. Here we used CrispR-Cas9-mediated gene editing to delete the gene encoding for AC, ASAH1, in human A375 melanoma cells. ASAH1-null clones show significantly greater accumulation of long-chain saturated ceramides that are substrate for AC. As seen with administration of exogenous ceramide, AC ablation blocks cell cycle progression and accelerates senescence. Importantly, ASAH1-null cells also lose the ability to form cancer-initiating cells and to undergo self-renewal, which is suggestive of a key role for AC in maintaining malignancy and self-renewal of invasive melanoma cells. The results suggest that AC inhibitors might find therapeutic use as adjuvant therapy for advanced melanoma

The Effect of the Short-Range Correlations on the Generalized Momentum Distribution in Finite Nuclei

The effect of dynamical short-range correlations on the generalized momentum distribution $n(\vec{p},\vec{Q})$ in the case of $Z=N$, $\ell$-closed shell nuclei is investigated by introducing Jastrow-type correlations in the harmonic-oscillator model. First, a low order approximation is considered and applied to the nucleus $^4$He. Compact analytical expressions are derived and numerical results are presented and the effect of center-of-mass corrections is estimated. Next, an approximation is proposed for $n(\vec{p}, \vec{Q})$ of heavier nuclei, that uses the above correlated $n(\vec{p},\vec{Q})$ of $^4$He. Results are presented for the nucleus $^{16}$O. It is found that the effect of short-range correlations is significant for rather large values of the momenta $p$ and/or $Q$ and should be included, along with center of mass corrections for light nuclei, in a reliable evaluation of $n(\vec{p},\vec{Q})$ in the whole domain of $p$ and $Q$.Comment: 29 pages, 8 figures. Further results, figures and discussion for the CM corrections are added. Accepted by Journal of Physics

The Effect of Learning Organization Environment and Innovative Work Behavior Under the Moderation Role of Employee Engagement in Public Sector Organization

The main objective of the study is to explore the impact of learning organization environment on innovative work behavior. The study results show that learning organization environment explained a significant relation with innovative work behavior also with the mediator variable that is employee engagement. Convenience sampling is used as the sampling strategy. This survey is based on questionnaire and data is collected from 140 managers of Public sector organizations located in Faisalabad. To analyses the data, SPSS version 23.0 is used. To check the relationship between the variables correlation analysis is used and to checks the effect between variables linear regression analysis is used. Thus, all the hypotheses showed significant results. Keywords: Learning Organization environment, innovative work behavior, employee engagemen

Time correlations in a confined magnetized free-electron gas

The time-dependent pair correlation functions for a degenerate ideal quantum gas of charged particles in a uniform magnetic field are studied on the basis of equilibrium statistics. In particular, the influence of a flat hard wall on the correlations is investigated, both for a perpendicular and a parallel orientation of the wall with respect to the field. The coherent and incoherent parts of the time-dependent structure function in position space are determined from an expansion in terms of the eigenfunctions of the one-particle Hamiltonian. For the bulk of the system, the intermediate scattering function and the dynamical structure factor are derived by taking successive Fourier transforms. In the vicinity of the wall the time-dependent coherent structure function is found to decay faster than in the bulk. For coinciding positions near the wall the form of the structure function turns out to be independent of the orientation of the wall. Numerical results are shown to corroborate these findings.Comment: 25 pages, 14 figures, to be published in Journal of Physics

Hypoglycemic, antiglycation, and cytoprotective properties of a phenol-rich extract from waste peel of punica granatum L. Var. Dente di cavallo DC2

Pomegranate peel is a natural source of phenolics, claimed to possess healing properties, among which are antioxidant and antidiabetic. In the present study, an ethyl acetate extract, obtained by Soxhlet from the peel of Dente di Cavallo DC2 pomegranate (PGE) and characterized to contain 4% w/w of ellagic acid, has been evaluated for its hypoglycemic, antiglycation, and antioxidative cytoprotective properties, in order to provide possible evidence for future nutraceutical applications. The α-amylase and α-glucosidase enzyme inhibition, interference with advanced glycation end-products (AGE) formation, and metal chelating abilities were studied. Moreover, the possible antioxidant cytoprotective properties of PGE under hyperglycemic conditions were assayed. Phenolic profile of the extract was characterized by integrated chromatographic and spectrophotometric methods. PGE resulted able to strongly inhibit the tested enzymes, especially α-glucosidase, and exerted chelating and antiglycation properties. Also, it counteracted the intracellular oxidative stress under hyperglycemic conditions, by reducing the levels of reactive oxygen species and total glutathione. Among the identified phenolics, rutin was the most abundant flavonoid (about 4 % w/w). Present results suggest PGE to be a possible remedy for hyperglycemia management and encourage further studies to exploit its promising properties