Review of Lee Morrissey, The Constitution of Literature: Literacy, Democracy, and Early English Literary Criticism.

Lee Morrissey, The Constitution of Literature: Literacy, Democracy, and Early English Literary Criticism. Stanford: Stanford University Press, 2008. 242 pp (+ xiii) ISBN 9780804757860

Review of Lee Morrissey, The Constitution of Literature: Literacy, Democracy, and Early English Literary Criticism.

Lee Morrissey, The Constitution of Literature: Literacy, Democracy, and Early English Literary Criticism. Stanford: Stanford University Press, 2008. 242 pp (+ xiii) ISBN 9780804757860

Perancangan Board Game untuk Edukasi Anak tentang Menjaga Kelestarian Biota Laut dari Sampah Plastik

Indonesia memiliki komposisi sampah plastik di laut yang tinggi sehingga menyebabkan banyak biota laut terancam musnah. Walaupun hal ini sedang terjadi, anak-anak di Indonesia tidak peka mengenai isu tersebut yang dibuktikan oleh pengumpulan data yaitu wawancara dan FGD. Berdasarkan pengumpulan data, penulis menemukan bahwa kurangnya edukasi dari sekolah menyebabkan anak-anak masih belum mengetahui tentang masalah pencemaran sampah plastik di laut dan pentingnya melestarikan biota laut. Maka dari itu, penulis merancang board game edukasi untuk anak 9-12 tahun dengan judul "Laut Lestari" yang dirancang menggunakan metode perancangan board game oleh Selinker dengan tahapan concepting, design dan development. Board game "Laut Lestari" mengambil referensi dari The Game of Life dan Ocean Crisis serta menggunakan gaya ilustrasi kartun untuk memberikan kesan yang fun. Hasil dari playtest board game ini dengan target audiens menunjukkan bahwa audiens menjadi paham tentang pentingnya menjaga kelestarian biota laut dari sampah plastik dan cara melestarikannya

[Introduction to] Treating Black Women with Eating Disorders : a Clinician’s Guide

The first of its kind, this edited volume provides in-depth, culturally sensitive material intended for addressing the unique concerns of Black women with eating disorders in addition to comprehensive discussions and treatment guidelines for this population. The contributing authors—all of whom are Black professionals providing direct care to Black women—offer a range of perspectives to help readers understand the whole experience of their Black female clients. This includes not only discussion of their clients’ physical health but also of their emotional lives and the ways in which the stresses of racism, discrimination, trauma, and adverse childhood experiences can contribute to disordered eating. Through a wealth of diverse voices and stories, chapters boldly tackle issues such as stereotypes and acculturative stress. Clinicians of any race will gain new tools for assessing, diagnosing, and treating disordered eating in Black women and will be empowered to provide better care for their clients.https://scholarship.richmond.edu/bookshelf/1376/thumbnail.jp

Neurotensin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Neurotensin receptors (nomenclature as recommended by NC-IUPHAR [38]) are activated by the endogenous tridecapeptide neurotensin (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) derived from a precursor (NTS, 30990), which also generates neuromedin N, an agonist at the NTS2 receptor. [3H]neurotensin (human, mouse, rat) and [125I]neurotensin (human, mouse, rat) may be used to label NTS1 and NTS2 receptors at 0.1-0.3 and 3-5 nM concentrations respectively

Neurotensin receptors in GtoPdb v.2023.1

Neurotensin receptors (nomenclature as recommended by NC-IUPHAR [39]) are activated by the endogenous tridecapeptide neurotensin (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) derived from a precursor (NTS, 30990), which also generates neuromedin N, an agonist at the NTS2 receptor. [3H]neurotensin (human, mouse, rat) and [125I]neurotensin (human, mouse, rat) may be used to label NTS1 and NTS2 receptors at 0.1-0.3 and 3-5 nM concentrations respectively

The Involvement of Sortilin/NTSR3 in Depression as the Progenitor of Spadin and Its Role in the Membrane Expression of TREK-1

The molecular identification of sortilin, also called neurotensin receptor-3, from three different biochemical approaches already predicted the involvement of the protein in numerous biological and cellular functions. The first important observation was that sortilin is synthesized as a precursor that is converted to a mature protein after cleavage by the protein convertase furin in late Golgi compartments. This maturation leads to the formation of a 44 amino acid peptide, the propeptide (PE). The release of this peptide when matured sortilin reached the plasma membrane remained to be demonstrated. Sortilin has been also shown to be shedded by matrix metalloproteases releasing a large extracellular fragment identified as soluble sortilin. Therefore, sortilin has been shown to interact with several proteins and receptors confirming its role in the sorting of cellular components to the plasma membrane and/or to the lysosomal pathway. Interestingly, sortilin physically interacts with the two pore domain potassium channel TREK-1 and the PE as well as its synthetic analog spadin is able to block the activation of TREK-1 highlighting their role in the depression pathology. The present review describes the advance of research that led to these results and how both the soluble form of sortilin and the sortilin-derived PE have been detected in human serum and whose levels are affected in patients with major depressive disorder (MDD). The use of spadin as an antidepressant and the further role of soluble sortilin and of sortilin-derived PE as potential biomarkers during depression statement and/or remission of the pathology are considered and discussed in this review