6 research outputs found
In Vitro and in Vivo Visualization and Trapping of Fluorescent Magnetic Microcapsules in a Bloodstream
Remote
navigation and targeted delivery of biologically active compounds
is one of the current challenges in the development of drug delivery
systems. Modern methods of micro- and nanofabrication give us new
opportunities to produce particles and capsules bearing cargo to deploy
and possess magnetic properties to be externally navigated. In this
work we explore multilayer composite magnetic microcapsules as targeted
delivery systems in vitro and in vivo studies under natural conditions
of living organism. Herein, we demonstrate magnetic addressing of
fluorescent composite microcapsules with embedded magnetite nanoparticles
in blood flow environment. First, the visualization and capture of
the capsules at the defined blood flow by the magnetic field are shown
in vitro in an artificial glass capillary employing a wide-field fluorescence
microscope. Afterward, the capsules are visualized and successfully
trapped in vivo into externally exposed rat mesentery microvessels.
Histological analysis shows that capsules infiltrate small mesenteric
vessels whereas large vessels preserve the blood microcirculation.
The effect of the magnetic field on capsule preferential localization
in bifurcation areas of vasculature, including capsule retention at
the site once external magnet is switched off is discussed. The research
outcome demonstrates that microcapsules can be effectively addressed
in a blood flow, which makes them a promising delivery system with
remote navigation by the magnetic field
Material Solubility-Photovoltaic Performance Relationship in the Design of Novel Fullerene Derivatives for Bulk Heterojunction Solar Cells
Solar modulation of galactic cosmic rays during 2006-2015 based on PAMELA and ARINA data
Solar modulation of galactic protons with energies from 50 MeV up to dozens of GeV during July '06 - January '16 studied based on a data of the magnetic spectrometer PAMELA and scintillation spectrometer ARINA. This period is interesting because it covers the end of 23rd and current 24th cycles of solar activity, including the abnormally long transient period and change of the polarity of solar magnetic field
Molecular structure-device performance relationship in polymer solar cells based on indene-C-60 bis-adduct derivatives
Interfacial tension between two materials is a key parameter in determining their miscibility and, thus, their morphological behavior in blend films. In bulk heterojunction (BHJ)-type polymer solar cells (PSCs), control of the interfacial tension between the electron donor and the electron acceptor is critically important in order to increase miscibility and achieve optimized BHJ morphology for producing efficient exciton dissociation and charge transport. Herein, we report the synthesis of a series of indene-C-60 bis-adducts (ICBA) derivatives by modifying their end-groups with fluorine (FICBA), methoxy (MICBA) and bromine (BICBA) functional units. We systematically studied the effects of their structural changes on the blend morphology with poly(3-hexylthiophene) (P3HT) and their performance in the PSCs. The end-group modification of ICBA derivatives induced a dramatic change in their interfacial tensions with P3HT (i.e., from 4.9 to 8.3mN m(-1)), resulting in large variations in the power conversion efficiency (PCE) of the PSCs, ranging from 2.9 to 5.2%