545 research outputs found
Disinformation in Brazil: The 2019 Amazon Fires on Social Media
In this paper, Lyndon, Tse, Moore, and May-Hobbs examine the online spread of disinformation about the Amazon fires in Brazil in 2019. They outline the tactics used by supporters of Jair Bolsonaro to spread a disinformation narrative across social media platforms about the causes of the Amazon fires. This is used as a case study into the various tactics that actors use to spread disinformation online and the methodologies researchers can utilise to track the spread of disinformation. The authors discuss the methods used to analyse disinformation techniques, emphasising the importance of qualitative research in addition to the use of digital tools, and set out how the process of identification can be used in future studies into the spread of disinformation online
Robust estimation of microbial diversity in theory and in practice
Quantifying diversity is of central importance for the study of structure,
function and evolution of microbial communities. The estimation of microbial
diversity has received renewed attention with the advent of large-scale
metagenomic studies. Here, we consider what the diversity observed in a sample
tells us about the diversity of the community being sampled. First, we argue
that one cannot reliably estimate the absolute and relative number of microbial
species present in a community without making unsupported assumptions about
species abundance distributions. The reason for this is that sample data do not
contain information about the number of rare species in the tail of species
abundance distributions. We illustrate the difficulty in comparing species
richness estimates by applying Chao's estimator of species richness to a set of
in silico communities: they are ranked incorrectly in the presence of large
numbers of rare species. Next, we extend our analysis to a general family of
diversity metrics ("Hill diversities"), and construct lower and upper estimates
of diversity values consistent with the sample data. The theory generalizes
Chao's estimator, which we retrieve as the lower estimate of species richness.
We show that Shannon and Simpson diversity can be robustly estimated for the in
silico communities. We analyze nine metagenomic data sets from a wide range of
environments, and show that our findings are relevant for empirically-sampled
communities. Hence, we recommend the use of Shannon and Simpson diversity
rather than species richness in efforts to quantify and compare microbial
diversity.Comment: To be published in The ISME Journal. Main text: 16 pages, 5 figures.
Supplement: 16 pages, 4 figure
Three Dimensional Numerical General Relativistic Hydrodynamics I: Formulations, Methods, and Code Tests
This is the first in a series of papers on the construction and validation of
a three-dimensional code for general relativistic hydrodynamics, and its
application to general relativistic astrophysics. This paper studies the
consistency and convergence of our general relativistic hydrodynamic treatment
and its coupling to the spacetime evolutions described by the full set of
Einstein equations with a perfect fluid source. The numerical treatment of the
general relativistic hydrodynamic equations is based on high resolution shock
capturing schemes. These schemes rely on the characteristic information of the
system. A spectral decomposition for general relativistic hydrodynamics
suitable for a general spacetime metric is presented. Evolutions based on three
different approximate Riemann solvers coupled to four different discretizations
of the Einstein equations are studied and compared. The coupling between the
hydrodynamics and the spacetime (the right and left hand side of the Einstein
equations) is carried out in a treatment which is second order accurate in {\it
both} space and time. Convergence tests for all twelve combinations with a
variety of test beds are studied, showing consistency with the differential
equations and correct convergence properties. The test-beds examined include
shocktubes, Friedmann-Robertson-Walker cosmology tests, evolutions of
self-gravitating compact (TOV) stars, and evolutions of relativistically
boosted TOV stars. Special attention is paid to the numerical evolution of
strongly gravitating objects, e.g., neutron stars, in the full theory of
general relativity, including a simple, yet effective treatment for the surface
region of the star (where the rest mass density is abruptly dropping to zero).Comment: 45 pages RevTeX, 34 figure
Assessing Communities of Practice in health policy : A conceptual framework as a first step towards empirical research
Peer reviewe
A Study of Burkholderia pseudomallei in the Environment of Farms in Thanlyin and Hmawbi Townships, Myanmar.
Melioidosis is a tropical infection, first described in Myanmar but now rarely diagnosed there, which is widespread in Southeast Asia. The infection is predominantly acquired by people and animals through contact with soil or water. This study aimed to detect the causative organism, Burkholderia pseudomallei, in environmental samples from farms in Thanlyin and Hmawbi townships near Yangon, Myanmar. One hundred and twenty soil samples and 12 water samples were collected and processed using standard microbiological methods. Burkholderia species were isolated from 50 of the 120 (42%) soil samples but none of the water samples. Arabinose assimilation was tested to differentiate between B. pseudomallei and the nonpathogenic Burkholderia thailandensis, and seven of 50 isolates (14%) were negative. These were all confirmed as B. pseudomallei by a species-specific multiplex polymerase chain reaction (PCR). This is the first study to detect environmental B. pseudomallei in Myanmar and confirms that melioidosis is still endemic in the Yangon area
Maintenance treatment with quetiapine versus discontinuation after one year of treatment in patients with remitted first episode psychosis: randomised controlled trial
Objective To study rates of relapse in remitted patients with first episode psychosis who either continued or discontinued antipsychotic drugs after at least one year of maintenance treatment
Suitability mapping for integrated aquatic food production systems – Decision Support System User Guide. Burmese version
The Integrated Aquatic Food Production System Decision Support System (IAFP DSS) provides a standardised approach to suitability analysis, enabling decision makers and stakeholders to engage with the technique in a simplistic yet comprehensive manner. The tool is suitable for application by a range of bodies including governmental and non-governmental organisations, research organisations and NGOs that have an interest in supporting the development of tailored and targeted investments for integrated aquatic food production systems within a given region. This report is the user guidelines translated in Burmese which support the training of the trainers implemented in Myanmar
Androgen Excess Produces Systemic Oxidative Stress and Predisposes to β-Cell Failure in Female Mice
In women, excess production of the male hormone, testosterone (T), is accompanied by insulin resistance. However, hyperandrogenemia is also associated with β-cell dysfunction and type 2 diabetes raising the possibility that androgen receptor (AR) activation predisposes to β-cell failure. Here, we tested the hypothesis that excess AR activation produces systemic oxidative stress thereby contributing to β-cell failure. We used normal female mice (CF) and mice with androgen resistance by testicular feminization (Tfm). These mice were exposed to androgen excess and a β-cell stress induced by streptozotocin (STZ). We find that following exposure to T, or the selective AR-agonist dehydrotestosterone (DHT), CF mice challenged with STZ, which are normally protected, are prone to β-cell failure and insulin-deficient diabetes. Conversely, T-induced predisposition to β-cell failure is abolished in Tfm mice. We do not observe any proapoptotic effect of DHT alone or in the presence of H2O2 in cultured mouse and human islets. However, we observe that exposure of CF mice to T or DHT provokes systemic oxidative stress, which is eliminated in Tfm mice. This work has significance for hyperandrogenic women; excess activation of AR by testosterone may provoke systemic oxidative stress. In the presence of a prior β-cell stress, this may predispose to β-cell failure
Quantum dynamics in strong fluctuating fields
A large number of multifaceted quantum transport processes in molecular
systems and physical nanosystems can be treated in terms of quantum relaxation
processes which couple to one or several fluctuating environments. A thermal
equilibrium environment can conveniently be modelled by a thermal bath of
harmonic oscillators. An archetype situation provides a two-state dissipative
quantum dynamics, commonly known under the label of a spin-boson dynamics. An
interesting and nontrivial physical situation emerges, however, when the
quantum dynamics evolves far away from thermal equilibrium. This occurs, for
example, when a charge transferring medium possesses nonequilibrium degrees of
freedom, or when a strong time-dependent control field is applied externally.
Accordingly, certain parameters of underlying quantum subsystem acquire
stochastic character. Herein, we review the general theoretical framework which
is based on the method of projector operators, yielding the quantum master
equations for systems that are exposed to strong external fields. This allows
one to investigate on a common basis the influence of nonequilibrium
fluctuations and periodic electrical fields on quantum transport processes.
Most importantly, such strong fluctuating fields induce a whole variety of
nonlinear and nonequilibrium phenomena. A characteristic feature of such
dynamics is the absence of thermal (quantum) detailed balance.Comment: review article, Advances in Physics (2005), in pres
- …