Intangible economy : How can investors deliver change in businesses? Lessons from nonprofit-business partnerships

Investors traditionally prioritised tangible outcomes (money, land, machinery) in order to protect their financial assets. However, the intangible economy (trust, human resources, information, reputation) that co-exists draws attention to new expectations that request the continuous, active and within the public sphere involvement of investors in order to protect their assets by prioritising intangible resources. The paper argues that investors in intangible outcomes who aim to achieve change in corporations share the same limitations within the financial and non-financial field. The case of Nonprofit-Business Partnerships is employed in order to demonstrate how change can be achieved. The role of investors is crucial in facilitating the shift from the tangible to the intangible economy. Investment in the intangible economy is a mechanism of co-determining the priority of responsibilities in the context of corporate social responsibility

Homology of E_n Ring Spectra and Iterated THH

We describe an iterable construction of THH for an E_n ring spectrum. The reduced version is an iterable bar construction and its n-th iterate gives a model for the shifted cotangent complex at the augmentation, representing reduced topological Quillen homology of an augmented E_n algebra.Comment: Some additional exposition added. Minor correction

Adapting Project-Based Learning For English-Language Learners In Middle-School Social Studies

This research project addresses the question, how can Project-Based Learning (PBL) be adapted to enhance middle school social studies lessons and learning outcomes for English Language Learners and other struggling students? It reviews theory and practice for middle-school social studies teachers to invite ELLs and others reading below grade level into authentic PBL. Supports for PBL should include effective language acquisition scaffolds like Guided Language Acquisition Design (GLAD) and content engagement through non-text, multimedia strategies like Visual Thinking Strategies (VTS) to invite students into deeper critical thinking and rigorous collaborative projects. Research connections are made to constructivist theories of Dewey and Kilpatrick, social learning theories of Vygotsky, language acquisition theories of Krashen, Project-Based Learning design of Boss, Larmer, and Misco, culturally-relevant teaching of Ladson-Billings and Milner, and VTS implementation of Housen and Yenawine. Findings were that educators can use scaffolding for ELLs in PBL work along with structured roles and routines, small group work, and modeling as needed to facilitate research, writing, and critical discussion. PBL with ELL scaffolds increases literacy and language acquisition because it engages students to solve problems using social learning using both academic and common English. Other outcomes include gains in critical thinking skills, cultural literacy, writing skills, and student self-concept

AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins

The purpose of this study was to elucidate the mechanisms associated with the specific effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the abundance of specific AKT isoforms in IBH-6 and T47D human breast cancer cell lines and showed that AKT1 promoted cell proliferation, through S6 and cyclin D1 upregulation, but it inhibited cell migration and invasion through β1-integrin and focal adhesion kinase (FAK) downregulation. In contrast, AKT2 promoted cell migration and invasion through F-actin and vimentin induction. Thus, while overexpression of AKT1 promoted local tumor growth, downregulation of AKT1 or overexpression of AKT2 promoted peritumoral invasion and lung metastasis. Furthermore, we evaluated The Cancer Genome Atlas (TCGA) dataset for invasive breast carcinomas and found that increased AKT2 but not AKT1 mRNA levels correlated with a worse clinical outcome. We conclude that AKT isoforms play specific roles in different steps of breast cancer progression, with AKT1 involved in the local tumor growth and AKT2 involved in the distant tumor dissemination, having AKT2 a poorer prognostic value and consequently being a worthwhile target for therapy.Fil: Riggio, Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Perrone, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Polo, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rodriguez, Maria Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: May, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Abba, Martín Carlos. Universidad Nacional de La Plata; ArgentinaFil: Lanari, Claudia Lee Malvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Novaro, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin

Homology and Cohomology of E-infinity Ring Spectra

Every homology or cohomology theory on a category of E-infinity ring spectra is Topological Andre-Quillen homology or cohomology with appropriate coefficients. Analogous results hold for the category of A-infinity ring spectra and for categories of algebras over many other operads

PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma-secretase inhibitor

Ovarian cancer is the fifth leading cause of cancer-related deaths in women. In the past 20 years, the canonical types of drugs used to treat ovarian cancer have not been replaced and the survival rates have not changed. These facts show the clear need to find new therapeutic strategies for this illness. Thus, the aim of the present study was to investigate the effect of a gamma-secretase inhibitor (DAPT) in combination with the Platelet-derived growth factor B (PDGFB) on an ovarian cancer xenograft model. To achieve this goal, we analyzed the effect of the administration of DAPT alone and the co-administration of DAPT and recombinant PDGFB on parameters associated with tumour growth and angiogenesis in an orthotopic experimental model of ovarian cancer. We observed that the dose of DAPT used was ineffective to reduce ovarian tumour growth, but showed anticancer activity when co-administered with recombinant PDGFB. The administration of PDGFB alone normalized tumour vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. Our findings suggest that PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. We propose that this therapeutic strategy could be a new tool for ovarian cancer treatment and deserves further studies.Fil: Pazos Maidana, María Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Sequeira, Gonzalo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Bocchicchio, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: May, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; ArgentinaFil: Abramovich, Dalhia Nurit. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Parborell, Maria Fernanda Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Tesone, Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Irusta, Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin

Alternative causal inference methods in population health research: Evaluating tradeoffs and triangulating evidence.

Population health researchers from different fields often address similar substantive questions but rely on different study designs, reflecting their home disciplines. This is especially true in studies involving causal inference, for which semantic and substantive differences inhibit interdisciplinary dialogue and collaboration. In this paper, we group nonrandomized study designs into two categories: those that use confounder-control (such as regression adjustment or propensity score matching) and those that rely on an instrument (such as instrumental variables, regression discontinuity, or differences-in-differences approaches). Using the Shadish, Cook, and Campbell framework for evaluating threats to validity, we contrast the assumptions, strengths, and limitations of these two approaches and illustrate differences with examples from the literature on education and health. Across disciplines, all methods to test a hypothesized causal relationship involve unverifiable assumptions, and rarely is there clear justification for exclusive reliance on one method. Each method entails trade-offs between statistical power, internal validity, measurement quality, and generalizability. The choice between confounder-control and instrument-based methods should be guided by these tradeoffs and consideration of the most important limitations of previous work in the area. Our goals are to foster common understanding of the methods available for causal inference in population health research and the tradeoffs between them; to encourage researchers to objectively evaluate what can be learned from methods outside one's home discipline; and to facilitate the selection of methods that best answer the investigator's scientific questions

Fluency, Text Structure, and Retelling: A Complex Relationship

This study examined the relationship between fluency and comprehension, specifically related to the text structures of narration and dialogue. Using descriptive statistics, this investigation first examined fluency and comprehension of three teacher educators and then through action research examined fluency and comprehension of five third grade students. Our findings showed that, as measured by retelling, the text structures of narration and dialogue impacted both fluency rate and comprehension

Evolving social capital and networks in the post‐disaster rebuilding process: the case of Typhoon Yolanda

Typhoon Yolanda brought major devastation to the local communities and infrastructure and also reshaped social structures and networks in the Philippines. During the immediate recovery process, bridging, bonding and linking social capital have had differential impacts and outcomes on how communities cope with the aftermath of the disaster. This paper investigates the interplay between the various types of social capital and their contributions to immediate coping strategies of Typhoon Yolanda communities. This paper also evaluates the complexity of defining social capital in a disaster context. In particular, it unpacks the blurring of the bridging and linking social capital at the immediate stage of rehabilitation in a post disaster context and its impacts on the social fabric of the communities. We deduce from this case study the social capital strategies necessary for a speedy recovery process both economically and socially for disaster-affected communities

Poverty Alleviation in the Wake of Typhoon Yolanda Workshop Findings: Working Paper I

The following observations are drawn from the opening workshop of the ESRC/DFID funded project (Ref: ES/M008932/1), ‘Poverty Alleviation in the Wake of Typhoon Yolanda’. The workshop was held on 30 September 2015 at Balay Kalinaw, University of the Philippines, Diliman, Quezon City, Philippines. Delegates at the workshop were drawn from academia, civil society, the business community and the military2. Around 50 delegates attended the workshop. All of the delegates involved in the workshop were experts or had experience in disaster relief either in the field or as a topic of academic and policy research. Experts were drawn from the Philippines, Cambodia, Myanmar and Thailand. In some cases workshop delegates were on the ground during Typhoon Yolanda (international name: Haiyan) or the immediate aftermath. The workshop was composed of three panels entitled: ‘Poverty Alleviation in the Wake of Natural Disasters’, ‘Livelihood and Community’ and ‘Governance and Resilience’, and a closing round table discussion.ESRC-DFI