Growth hormone receptor deficiency (Laron syndrome) in black African siblings

Non-Caucasians with growth honnone receptor (GHR) deficiency/Lamn syndrome among the approximately 180 recognised cases are rare, and include a Japanese and 3 African Americans. Black African siblings, a brother and a sister seen initially at 11 years 9 months and 5 years 6 months of age respectively were -7,4 and -8,0 on the standard deviation score for height. They had characteristic features and biochemical findings including prominent forehead; depressed nasal bridge; central adiposity; high-pitched voices; micropenis; high GH levels and low levels of insulin-like growth factor (IGF)-I, IGF-II, insulin-like growth factor-binding protein 3 (IGFBP-3), and GH-binding protein (the solubilised extracellular domain of the GH cell surface receptor). Molecular genetic studies revealed a dinucleotide deletion in both siblings on exon 7 of the GHR gene, a mutation not found in any other G.HRdeficient patient studied, including the North Americans of African origin. Since African Americans have a substantial admixture of Caucasian genes, n is of interest to document the presence of this ccndnion in siblings from Afric

Growth hormone receptor deficiency (Laron syndrome) in black African siblings

Non-Caucasians with growth honnone receptor (GHR) deficiency/Laron syndrome among the approximately 180 recognised cases are rare, and include a Japanese and 3 African Americans. Black African siblings, a brother and a sister seen initially at 11 years 9 months and 5 years 6 months of age respectively were -7,4 and -8,0 on the standard deviation score for height. They had characteristic features and biochemical findings including prominent forehead; depressed nasal bridge; central adiposity; high-pitched voices; micropenis; high GH levels and low levels of insulin-like growth factor (IGF)-I, IGF-II, insulin-like growth factor-binding protein 3 (IGFBP-3), and GH-binding protein (the solubilised extracellular domain of the GH cell surface receptor). Molecular genetic studies revealed a dinucleotide deletion in both siblings on exon 7 of the GHR gene, a mutation not found in any other G.HR-deficient patient studied, including the North Americans of African origin. Since African Americans have a substantial admixture of Caucasian genes, it is of interest to document the presence of this condition in siblings from Afric

Periodic and Almost Periodic Solution Behavior of Four Dynamic Riccati Equations on Time Scales

Color poster with text, graphs, and equations.We focus on asymptotic solution behavior of both dynamic Riccati equations on the time scale uZ, where u is a positive real number. Using the time scale calculus, we develop a general solution to the Delta Riccati equation using generalized sines and cosines, and the generalized exponential function for time scales.University of Wisconsin--Eau Claire Office of Research and Sponsored Programs