A Letter of Intent to Install a milli-charged Particle Detector at LHC P5

In this LOI we propose a dedicated experiment that would detect "milli-charged" particles produced by pp collisions at LHC Point 5. The experiment would be installed during LS2 in the vestigial drainage gallery above UXC and would not interfere with CMS operations. With 300 fb$^{-1}$ of integrated luminosity, sensitivity to a particle with charge $\mathcal{O}(10^{-3})~e$ can be achieved for masses of $\mathcal{O}(1)$ GeV, and charge $\mathcal{O}(10^{-2})~e$ for masses of $\mathcal{O}(10)$ GeV, greatly extending the parameter space explored for particles with small charge and masses above 100 MeV.Comment: 19 pages, 7 figure

Yield Of Tifton 85 Grass Under Irrigation And Nitrogen Doses

The study was conducted on a dairy farm in the municipality of Xambre, Northwest region of Parana, in the period from March 2011 to February 2012 to evaluate the yield and botanical composition of Tifton 85 with and without irrigation under nitrogen doses. The experimental plots were implanted in completely randomized blocks with and without irrigation and subplots through four nitrogen levels: 0, 20, 40 and 60 kg ha(-1) per grazing cycle, with four replications. The yield in dry matter (DM) was higher under irrigation, responding linearly to increasing nitrogen fertilization. At a dose of 60 kg N ha(-1) yields of 39279 and 27826 kg DM ha(-1) were obtained, with and without irrigation, respectively. The leaf stem ratio was not affected by irrigation. The overall mean percentage of dead material with and without irrigation was equal to 13 and 17%, respectively.19431732

Yield of tifton 85 grass under irrigation and nitrogen doses

O trabalho foi conduzido em uma propriedade de atividade leiteirana município de Xambrê, região Noroeste do Paraná, no período de março de 2011 a fevereiro de 2012 com o objetivo de avaliar a produtividade e a composição botânica do capim Tifton 85 com e sem irrigação sob doses de nitrogênio. As parcelas experimentais foram implantadas com delineamento de blocos ao acaso com e sem irrigação e as subparcelas por meio de quatro doses de nitrogênio: 0, 20, 40 e 60 kg ha-1 ciclo de pastejo-1, com quatro repetições. A produtividade em matéria seca (MS) foi maior sob irrigaçãocrescendo de forma linear à adubação nitrogenada. Na dose de 60 kg N ha-1 foram obtidas produtividades iguais a 39279 e 27826 kg MS ha-1, com e sem irrigação, respectivamente. A relação folha colmo não foi afetada pela irrigação. A média geral do percentual de material morto com e sem irrigação, foi igual a 13 e 17%, respectivamente194317323The study was conducted on a dairy farm in the municipality of Xambre, Northwest region of Parana, in the period from March 2011 to February 2012 to evaluate the yield and botanical composition of Tifton 85 with and without irrigation under nitrogen doses. The experimental plots were implanted in completely randomized blocks with and without irrigation and subplots through four nitrogen levels: 0, 20, 40 and 60 kg ha(-1) per grazing cycle, with four replications. The yield in dry matter (DM) was higher under irrigation, responding linearly to increasing nitrogen fertilization. At a dose of 60 kg N ha(-1) yields of 39279 and 27826 kg DM ha(-1) were obtained, with and without irrigation, respectively. The leaf stem ratio was not affected by irrigation. The overall mean percentage of dead material with and without irrigation was equal to 13 and 17%, respectivel

The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice

Disturbed activation or regulation of the stress response through the hypothalamic-pituitary-adrenal (HPA) axis is a fundamental component of multiple stress-related diseases, including psychiatric, metabolic, and immune disorders. The FK506 binding protein 51 (FKBP5) is a negative regulator of the glucocorticoid receptor (GR), the main driver of HPA axis regulation, and FKBP5 polymorphisms have been repeatedly linked to stress-related disorders in humans. However, the specific role of Fkbp5 in the paraventricular nucleus of the hypothalamus (PVN) in shaping HPA axis (re)activity remains to be elucidated. We here demonstrate that the deletion of Fkbp5 in Sim1(+) neurons dampens the acute stress response and increases GR sensitivity. In contrast, Fkbp5 overexpression in the PVN results in a chronic HPA axis over-activation, and a PVN-specific rescue of Fkbp5 expression in full Fkbp5 KO mice normalizes the HPA axis phenotype. Single-cell RNA sequencing revealed the cell-type-specific expression pattern of Fkbp5 in the PVN and showed that Fkbp5 expression is specifically upregulated in Crh(+) neurons after stress. Finally, Crh-specific Fkbp5 overexpression alters Crh neuron activity, but only partially recapitulates the PVN-specific Fkbp5 overexpression phenotype. Together, the data establish the central and cell-type-specific importance of Fkbp5 in the PVN in shaping HPA axis regulation and the acute stress response

Soil Metabolome Response to Whole-Ecosystem Warming at the Spruce and Peatland Responses Under Changing Environments Experiment

While peatlands have historically stored massive amounts of soil carbon, warming is expected to enhance decomposition, leading to a positive feedback with climate change. In this study, a unique whole-ecosystem warming experiment was conducted in northern Minnesota to warm peat profiles to 2 m deep while keeping water flow intact. After nearly 2 y, warming enhanced the degradation of soil organic matter and increased greenhouse gas production. Changes in organic matter quality with warming were accompanied by a stimulation of methane production relative to carbon dioxide. Our results revealed increased decomposition to be fueled by the availability of reactive carbon substrates produced by surface vegetation. The elevated rates of methanogenesis are likely to persist and exacerbate climate warming

Cancer therapy shapes the fitness landscape of clonal hematopoiesis.

Acquired mutations are pervasive across normal tissues. However, understanding of the processes that drive transformation of certain clones to cancer is limited. Here we study this phenomenon in the context of clonal hematopoiesis (CH) and the development of therapy-related myeloid neoplasms (tMNs). We find that mutations are selected differentially based on exposures. Mutations in ASXL1 are enriched in current or former smokers, whereas cancer therapy with radiation, platinum and topoisomerase II inhibitors preferentially selects for mutations in DNA damage response genes (TP53, PPM1D, CHEK2). Sequential sampling provides definitive evidence that DNA damage response clones outcompete other clones when exposed to certain therapies. Among cases in which CH was previously detected, the CH mutation was present at tMN diagnosis. We identify the molecular characteristics of CH that increase risk of tMN. The increasing implementation of clinical sequencing at diagnosis provides an opportunity to identify patients at risk of tMN for prevention strategies