1,108 research outputs found
Images, structural properties and metal abundances of galaxy clusters observed with Chandra ACIS-I at 0.1<z<1.3
We have assembled a sample of 115 galaxy clusters at 0.1<z<1.3 with archived
Chandra ACIS-I observations. We present X-ray images of the clusters and make
available region files containing contours of the smoothed X-ray emission. The
structural properties of the clusters were investigated and we found a
significant absence of relaxed clusters (as determined by centroid shift
measurements) at z>0.5. The slope of the surface brightness profiles at large
radii were steeper on average by 15% than the slope obtained by fitting a
simple beta-model to the emission. This slope was also found to be correlated
with cluster temperature, with some indication that the correlation is weaker
for the clusters at z>0.5. We measured the mean metal abundance of the cluster
gas as a function of redshift and found significant evolution, with the
abundances dropping by 50% between z=0.1 and z~1. This evolution was still
present (although less significant) when the cluster cores were excluded from
the abundance measurements, indicating that the evolution is not solely due to
the disappearance of relaxed, cool core clusters (which are known to have
enhanced core metal abundances) from the population at z>0.5.Comment: 23 pages, 12 figures. Accepted for publication in ApJS. Updated to
match published version. Redshifts of two clusters (RXJ1701 and CL0848)
corrected and two observations of MACSJ0744.8 have been combined into one.
Conclusions unchanged. A version with images of all of the clusters is
available at http://hea-www.harvard.edu/~bmaughan/clusters.htm
A phase II study of capecitabine and oxalplatin combination chemotherapy in patients with inoperable adenocarcinoma of the gall bladder or biliary tract
Background: Advanced biliary tract carcinomas are associated with a poor prognosis, and palliative chemotherapy has only modest benefit. This multi-centre phase II study was conducted to determine the efficacy of capecitabine in combination with oxaliplatin in patients with inoperable gall bladder or biliary tract cancer. Methods: This was a Phase II, non-randomised, two-stage Simon design, multi-centre study. Ethics approval was sought and obtained by the North West MREC, and then locally by the West Glasgow Hospitals Research Ethics Com mittee. Eligible patients with inoperable locally advanced or metastatic adenocarcinoma of the gall bladder or biliary tract and with adequate performance status, haematologic, renal, and hepatic function were treated with capecit abine (1000 mg/m2 po, twice daily, days 1–14) and oxaliplatin (130 mg/m2 i.v., day 1) every 3 weeks for up to six cycles. The primary objective of the study was to determine the objective tumour response rates (complete and partial). The secondary objectives included assessment of toxicity, progression-free survival, and overall survival. Results: Forty-three patients were recruited between July 2003 and December 2005. The regimen was well tolerated with no grade 3/4 neutropenia or thrombocytopenia. Grade 3/4 sensory neuropathy was observed in six patients. Two-thirds of patients received their chemotherapy without any dose delays. Overall response rate was 23.8 % (95 % CI 12.05–39.5 %). Stable disease was observed in a further 13 patients (31 %) and progressive disease observed in 12 (28.6 %) of patients. The median progression-free survival was 4.6 months (95 % CI 2.8–6.4 months; Fig. 1) and the median overall survival 7.9 months (95 % CI 5.3–10.4 months; Fig. 2). Conclusion: Capecitabine combined with oxaliplatin has a lower disease control and shorter overall survival than the combination of cisplatin with gemcitabine which has subsequently become the standard of care in this disease. How ever, capecitabine in combination with oxaliplatin does have modest activity in this disease, and can be considered as an alternative treatment option for patients in whom cisplatin and/or gemcitabine are contra-indicated
Manipulating O3/P2 phase ratio in bi-phasic sodium layered oxides via ionic radius control
Funding: This work was supported by the Faraday Institution (Grant number FIRG018). The authors would like to thank Dr. David Rochester at Lancaster University for conducting the ICP-OES experiments. A.B.N. would like to acknowledge funding by the Engineering and Physical Sciences Research Council under grant numbers EP/L017008/1, EP/R023751/1, and EP/T019298/1 for the electron microscopy analysis.Bi-phasic O3/P2 sodium layered oxides have emerged as leading candidates for the commercialisation of next-generation sodium-ion batteries. However, beyond simply altering the sodium content, rational control of the O3/P2 ratio in these materials has proven particularly challenging despite being crucial for the realization of high-performance electrode materials. Here, using abundant elements, we manipulate the O3/P2 ratio using the average ionic radius of the transition metal layer and different synthesis conditions. These methods allow deterministic control over the O3/P2 ratio, even for constant Na contents. In addition, tuning the O3/P2 ratio yields high-performing materials with different performance characteristics, with a P2-rich material achieving high rate capabilities and excellent cycling stability (92% retention, 50 cycles), while an O3-rich material displayed an energy density up to 430 Wh kg−1, (85%, 50 cycles). These insights will help guide the rational design of future high-performance materials for sodium-ion batteries.Publisher PDFPeer reviewe
The XMM-LSS survey: the Class 1 cluster sample over the extended 11 deg and its spatial distribution
This paper presents 52 X-ray bright galaxy clusters selected within the 11
deg XMM-LSS survey. 51 of them have spectroscopic redshifts
(), one is identified at , and all together make
the high-purity "Class 1" (C1) cluster sample of the XMM-LSS, the highest
density sample of X-ray selected clusters with a monitored selection function.
Their X-ray fluxes, averaged gas temperatures (median keV),
luminosities (median ergs/s) and total mass
estimates (median ) are measured, adapting to
the specific signal-to-noise regime of XMM-LSS observations. The redshift
distribution of clusters shows a deficit of sources when compared to the
cosmological expectations, regardless of whether WMAP-9 or Planck-2013 CMB
parameters are assumed. This lack of sources is particularly noticeable at . However, after quantifying uncertainties due to small
number statistics and sample variance we are not able to put firm (i.e. ) constraints on the presence of a large void in the cluster
distribution. We work out alternative hypotheses and demonstrate that a
negative redshift evolution in the normalization of the relation
(with respect to a self-similar evolution) is a plausible explanation for the
observed deficit. We confirm this evolutionary trend by directly studying how
C1 clusters populate the space, properly accounting for selection
biases. We point out that a systematically evolving, unresolved, central
component in clusters and groups (AGN contamination or cool core) can impact
the classification as extended sources and be partly responsible for the
observed redshift distribution.[abridged]Comment: 33 pages, 21 figures, 3 tables ; accepted for publication in MNRA
The XXL Survey X: K-band luminosity - weak-lensing mass relation for groups and clusters of galaxies
We present the K-band luminosity-halo mass relation, ,
for a subsample of 20 of the 100 brightest clusters in the XXL Survey observed
with WIRCam at the Canada-France-Hawaii Telescope (CFHT). For the first time,
we have measured this relation via weak-lensing analysis down to . This allows us to investigate whether the slope
of the relation is different for groups and clusters, as seen in other
works. The clusters in our sample span a wide range in mass, , at . The K-band luminosity
scales as with and an
intrinsic scatter of . Combining our
sample with some clusters in the Local Cluster Substructure Survey (LoCuSS)
present in the literature, we obtain a slope of and an
intrinsic scatter of . The flattening in the seen
in previous works is not seen here and might be a result of a bias in the mass
measurement due to assumptions on the dynamical state of the systems. We also
study the richness-mass relation and find that group-sized halos have more
galaxies per unit halo mass than massive clusters. However, the brightest
cluster galaxy (BCG) in low-mass systems contributes a greater fraction to the
total cluster light than BCGs do in massive clusters; the luminosity gap
between the two brightest galaxies is more prominent for group-sized halos.
This result is a natural outcome of the hierarchical growth of structures,
where massive galaxies form and gain mass within low-mass groups and are
ultimately accreted into more massive clusters to become either part of the BCG
or one of the brighter galaxies. [Abridged]Comment: A&A, in pres
Toxicity associated with combination oxaliplatin plus fluoropyrimidine with or without cetuximab in the MRC COIN trial experience
We present the preliminary toxicity data from the MRC COIN trial, a phase III randomised controlled trial of first-line therapy in advanced colorectal cancer, with particular reference to the addition of cetuximab to an oxaliplatin–fluoropyrimidine combination. A total of 804 patients were randomised between March 2005 and July 2006 from 78 centres throughout the United Kingdom. Patients were allocated to oxaliplatin plus fluoropyrimidine chemotherapy with or without the addition of weekly cetuximab. The choice of fluoropyrimidine (either 5-fluorouracil (5FU) or capecitabine) was decided by the treating physician and patient before randomisation. Toxicity data were collected from all patients. Two hundred and three patients received 5FU plus oxaliplatin (OxMdG, 25%), 333 oxaliplatin+capecitabine (Xelox, 41%), 102 received OxMdG+cetuximab (OxMdG+C, 13%) and 166 Xelox+cetuximab (21%). Percent grade 3/4 toxicities included diarrhoea 6, 15, 13 and 25%, nausea/vomiting 3, 7, 7 and 14% for OxMdG, Xelox, OxMdG+C and Xelox+C, respectively. Sixty-day all-cause mortality was 6, 5, 5 and 7%. Statistically significant differences were evident for patients receiving Xelox+cetuximab vs Xelox alone: diarrhoea relative risk (RR) 1.69 (1.17, 2.43, P=0.005) and nausea/vomiting RR 2.01 (1.16, 3.47, P=0.012). The excess toxicity observed in the oxaliplatin-, capecitabine-, cetuximab-treated patients led the trial management group to conclude that a capecitabine dose adjustment was required to maintain safety levels when using this regimen
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