Membrane assembly and ion transport ability of a fluorinated nanopore

A novel 21-residue peptide incorporating six fluorinated amino acids was prepared. It was designed to fold into an amphiphilic alpha helical structure of nanoscale length with one hydrophobic face and one fluorinated face. The formation of a fluorous interface serves as the main vector for the formation of a superstructure in a bilayer membrane. Fluorescence assays showed this ion channel's ability to facilitate the translocation of alkali metal ions through a phospholipid membrane, with selectivity for sodium ions. Computational studies showed that a tetramer structure is the most probable and stable supramolecular assembly for the active ion channel structure. The results illustrate the possibility of exploiting multiple Fd-:M+ interactions for ion transport and using fluorous interfaces to create functional nanostructures

Alternatives au glyphosate en grandes cultures. Evaluation économique: Evaluation économique

Travail réalisé à la demande du Premier Ministre et des Ministres en charge de l'Agriculture et la Transition Ecologique et Solidaire, dans le cadre du plan de sortie du glyphosate.Alternatives au glyphosate en grandes cultures . Evaluation économiqu

An anthropomorphic polyvinyl alcohol brain phantom based on Colin27 for use in multimodal imaging

International audienceIn this paper, the method for the creation of an anatomically and mechanically realistic brain phantom from polyvinyl alcohol cryogel (PVA-C) is proposed for validation of image processing methods such as segmentation, reconstruction, registration, and denoising. PVA-C is material widely used in medical imaging phantoms because of its mechanical similarities to soft tissues. The phantom was cast in a mold designed using the left hemisphere of the Colin27 brain dataset [C. Holmes et al., "Enhancement of MR images using registration for signal averaging," J. Comput. Assist. Tomogr. 22(2), 324 (1998)]. Marker spheres and inflatable catheters were also implanted to enable good registration comparisons and to simulate tissue deformation, respectively. The phantom contained deep sulci, a complete insular region, and an anatomically accurate left ventricle. It was found to provide good contrast in triple modality imaging, consisting of computed tomography, ultrasound, and magnetic resonance imaging. Multiple sets of multimodal data were acquired from this phantom. The methods for building the anatomically accurate, multimodality phantom were described in this work. All multimodal data are made available freely to the image processing community (http://pvabrain.inria.fr). We believe the phantom images could allow for the validation and further aid in the development of novel medical image processing techniques

Excavations at Sissi III: Preliminary Report on the 2011 Campaign

International audienc

Excavations at Sissi: Preliminary Report on the 2007 and 2008 Campaigns

International audienc

Excavations at Sissi, II. Preliminary Report on the 2009-2010 Campaigns

Since 2007, the Belgian School at Athens has undertaken excavations on the Kefali or Buffo hill, east of the village of Sissi, on the north coast of Crete where a Minoan site was occupied approximately between 2500 and 1200 BC. This volume is the follow-up of an earlier one on the 2007-2008 excavations (published as Aegis 1) and presents a preliminary report on the excavations carried out in 2009 and 2010. It concentrates on the different zones examined within the cemetery and settlement. There are also reports on the Late Minoan pottery, site conservation and environmental analysis as well as a paper on the use of GIS at Sissi