10 research outputs found
Techno-economic evaluation of an ultrasound-assisted Enzymatic Reactive Distillation process
Enzymatic Reactive Distillation (ERD) is a bioreactive process, in which enzymes are immobilized on column internal surface, and helps to overcome chemical reaction and phase equilibrium limitations. The activation of enzymes by ultrasound (US) leads to ultrasound-assisted ERD (US-ERD) which might display more eco-efficiency than standard processing of valuable chemicals. Reaction rate improvements of more than 50% could be achieved by the assistance of US. An US-ERD process for the synthesis of butyl butyrate (10 kilotons per year, 99 wt% purity) was designed. A techno-economic evaluation via process optimization was carried out to minimize the annual costs, by using an evolutionary algorithm. The techno-economic evaluation shows that the US-ERD process and the ERD share nearly equal costs. Installation costs of the US equipment are high but they are compensated by a 12% lower reactive section height and a 7% lower total height of the US-ERD column in comparison to ERD
Pilot-scale validation of Enzymatic Reactive Distillation for butyl butyrate production
For enzyme-catalyzed reactions, batch processes using stirred tank reactors are the state-of-the-art production mode. The yield of the process may be limited by reaction equilibrium, product inhibition of the enzyme, low concentrations and possibly low reaction rates, while the recovery of the product may be limited due to thermodynamic constraints such as azeotropes. Using enzymes in an integrated reactive distillation process can overcome these limitations and provides a cost advantage over classic batch reactor processes. The aim of this paper is i) to report the successful pilot-scale experimental validation of an Enzymatic Reactive Distillation (ERD) process for the synthesis of butyl butyrate and ii) to establish a rate-based model for conceptual process design which can be quickly adapted to other systems. The main novelty is the application of a continuous RD column with enzymes as a heterogeneous catalyst provided in two different types of catalytic packing: loosely filled immobilized enzyme beads in standard packings with catalyst pockets and gauze packings with catalytic coating. Experimental pilot-scale experiments show the feasibility of ERD and allow the comparison of the different packing types based on catalytic performance as well as stability. Furthermore, these experiments are used to validate a predictive rate-based model to describe ERD which can be used to check the sensitivity of process and design parameters as well as to provide a quick adaption to other systems for quick evaluation
Ultrasound-assisted emerging technologies for chemical processes
The chemical industry has witnessed many important developments during past decades largely enabled by process intensification techniques. Some of them are already proven at commercial scale (e.g. reactive distillation) while others (e.g. ultrasound-assisted extraction/crystallization/reaction) are on their way to becoming the next-generation technologies. This article focuses on the advances of ultrasound (US)-assisted technologies that could lead in the near future to significant improvements in commercial activities. The aim is to provide an authoritative discussion on US-assisted technologies that are currently emerging from the research environment into the chemical industry, as well as give an overview of the current state-of-the-art applications of US in chemical processing (e.g. enzymatic reactive distillation, crystallization of API). Sufficient information is included to allow the assessment of US-assisted technologies and the challenges for implementation, as well as their potential for commercial applications
Integration of Enzymatic Catalysts in a Continuous Reactive Distillation Column: Reaction Kinetics and Process Simulation
This work presents
a feasibility study for an enzymatic reaction
in a continuously operated reactive distillation column. As a model
reaction, the transesterification of ethyl butyrate with <i>n</i>-butanol in the presence of lipase CALB was considered. For use in
the distillation column, lipase CALB was immobilized by entrapment
in a hydrophobic silica xerogel and introduced as granulate into the
catalytic packing Katapak-SP-11. The reaction kinetics was experimentally
determined for different concentration and temperature ranges and
described by means of the Michaelis–Menten double-substrate
kinetic model in combination with the Arrhenius model. With these
kinetic data, process simulations were carried out with an Aspen Custom
Modeler nonequilibrium-stage model validated for a DN50 pilot-scale
column. The concentration of <i>n</i>-butanol in the reactive
section was maintained low to decrease the inhibiting effects on the
enzyme. For an optimized setup and operating conditions, conversion
rates of more than 90% were achieved for <i>n</i>-butanol
and 26% for ethyl butyrate. These results clearly demonstrate that
lipase CALB can be applied in a continuously operated reactive distillation
column
Preface: Focus on imaging methods in granular physics
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