1,131 research outputs found
Choice Architecture to Improve Financial Decision Making
This is the author accepted manuscript. The final version is available from MIT Press via the DOI in this recordWe exploit the principles of choice architecture to evaluate interventions in the
market for reloadable prepaid cards. Participants are randomized into three card
menu presentation treatments - the market status quo, a regulation-inspired reform, or an enhanced reform designed to minimize attribute overload - and offered choices based on prior structural estimation of individual preferences. Consumers routinely choose incorrectly under the status quo, with tentative evidence
the regulation-inspired presentation may increase best card choice, and clear evidence the enhanced reform reduces worst card choice. Welfare analysis suggests
the regulation-inspired presentation offers modest gains, while the enhanced policy
generates substantial benefits
Bose-Fermi Mixtures in Optical Lattices
Using mean field theory, we have studied Bose-Fermi mixtures in a
one-dimensional optical lattice in the case of an attractive boson-fermion
interaction. We consider that the fermions are in the degenerate regime and
that the laser intensities are such that quantum coherence across the
condensate is ensured. We discuss the effect of the optical lattice on the
critical rotational frequency for vortex line creation in the Bose-Einstein
condensate, as well as how it affects the stability of the boson-fermion
mixture. A reduction of the critical frequency for nucleating a vortex is
observed as the strength of the applied laser is increased. The onset of
instability of the mixture occurs for a sizeably lower number of fermions in
the presence of a deep optical lattice.Comment: 7 pages, 6 figures, revtex4, 14th International Laser Physics
Workshop (LPHYS'05
From Nonspecific DNA–Protein Encounter Complexes to the Prediction of DNA–Protein Interactions
©2009 Gao, Skolnick. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.doi:10.1371/journal.pcbi.1000341DNA–protein interactions are involved in many essential biological activities. Because there is no simple mapping code between DNA base pairs and protein amino acids, the prediction of DNA–protein interactions is a challenging problem. Here, we present a novel computational approach for predicting DNA-binding protein residues and DNA–protein interaction modes without knowing its specific DNA target sequence. Given the structure of a DNA-binding protein, the method first generates an ensemble of complex structures obtained by rigid-body docking with a nonspecific canonical B-DNA. Representative models are subsequently selected through clustering and ranking by their DNA–protein interfacial energy. Analysis of these encounter complex models suggests that the recognition sites for specific DNA binding are usually favorable interaction sites for the nonspecific DNA probe and that nonspecific DNA–protein interaction modes exhibit some similarity to specific DNA–protein binding modes. Although the method requires as input the knowledge that the protein binds DNA, in benchmark tests, it achieves better performance in identifying DNA-binding sites than three previously established methods, which are based on sophisticated machine-learning techniques. We further apply our method to protein structures predicted through modeling and demonstrate that our method performs satisfactorily on protein models whose root-mean-square Ca deviation from native is up to 5 Å from their native structures. This study provides valuable structural insights into how a specific DNA-binding protein interacts with a nonspecific DNA sequence. The similarity between the specific DNA–protein interaction mode and nonspecific interaction modes may reflect an important sampling step in search of its specific DNA targets by a DNA-binding protein
Pinning of quantized vortices in helium drop by dopant atoms and molecules
Using a density functional method, we investigate the properties of liquid
4He droplets doped with atoms (Ne and Xe) and molecules (SF_6 and HCN). We
consider the case of droplets having a quantized vortex pinned to the dopant. A
liquid drop formula is proposed that accurately describes the total energy of
the complex and allows one to extrapolate the density functional results to
large N. For a given impurity, we find that the formation of a
dopant+vortex+4He_N complex is energetically favored below a critical size
N_cr. Our result support the possibility to observe quantized vortices in
helium droplets by means of spectroscopic techniques.Comment: Typeset using Revtex, 3 pages and 5 figures (4 Postscript, 1 jpeg
Modelling and simulating change in reforesting mountain landscapes using a social-ecological framework
Natural reforestation of European mountain landscapes raises major environmental and societal issues. With local stakeholders in the Pyrenees National Park area (France), we studied agricultural landscape colonisation by ash (Fraxinus excelsior) to enlighten its impacts on biodiversity and other landscape functions of importance for the valley socio-economics. The study comprised an integrated assessment of land-use and land-cover change (LUCC) since the 1950s, and a scenario analysis of alternative future policy. We combined knowledge and methods from landscape ecology, land change and agricultural sciences, and a set of coordinated field studies to capture interactions and feedback in the local landscape/land-use system. Our results elicited the hierarchically-nested relationships between social and ecological processes. Agricultural change played a preeminent role in the spatial and temporal patterns of LUCC. Landscape colonisation by ash at the parcel level of organisation was merely controlled by grassland management, and in fact depended on the farmer's land management at the whole-farm level. LUCC patterns at the landscape level depended to a great extent on interactions between farm household behaviours and the spatial arrangement of landholdings within the landscape mosaic. Our results stressed the need to represent the local SES function at a fine scale to adequately capture scenarios of change in landscape functions. These findings orientated our modelling choices in the building an agent-based model for LUCC simulation (SMASH - Spatialized Multi-Agent System of landscape colonization by ASH). We discuss our method and results with reference to topical issues in interdisciplinary research into the sustainability of multifunctional landscapes
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A randomised controlled trial of cognitive behavioural treatment for obsessive compulsive disorder in children and adolescents
Cognitive behaviour therapy (CBT) for young people with obsessive compulsive disorder (OCD) has become the treatment of first choice. However, the literature is largely based on studies emphasising exposure and response prevention. In this study, we report on a randomised controlled trial of CBT for young people carried out in typical outpatient clinic conditions which focused on cognitions. A randomised controlled trial compares 10 sessions of manualised cognitive behavioural treatment with a 12-week waiting list for adolescents and children with OCD. Assessors were blind to treatment allocation. 21 consecutive patients with OCD aged between 9 and 18 years were recruited. The group who received treatment improved more than a comparison group who waited for 3 months. The second group was treated subsequently using the same protocol and made similar gains. In conclusion, CBT can be delivered effectively to young people with OCD in typical outpatient settings
Macroscopic quantum tunneling of two-component Bose-Einstein condensates
We show theoretically the existence of a metastable state and the possibility
of decay to the ground state through macroscopic quantum tunneling in
two-component Bose-Einstein condensates with repulsive interactions. Numerical
analysis of the coupled Gross-Pitaevskii equations clarifies the metastable
states whose configuration preserves or breaks the symmetry of the trapping
potential, depending on the interspecies interaction and the particle number.
We calculate the tunneling decay rate of the metastable state by using the
collective coordinate method under the WKB approximation. Then the height of
the energy barrier is estimated by the saddle point solution. It is found that
macroscopic quantum tunneling is observable in a wide range of particle
numbers. Macroscopic quantum coherence between two distinct states is
discussed; this might give an additional coherent property of two-component
Bose condensed systems. Thermal effects on the decay rate are estimated.Comment: 11 pages, 10 figures, revtex
Superchemistry: dynamics of coupled atomic and molecular Bose-Einstein condensates
We analyze the dynamics of a dilute, trapped Bose-condensed atomic gas
coupled to a diatomic molecular Bose gas by coherent Raman transitions. This
system is shown to result in a new type of `superchemistry', in which giant
collective oscillations between the atomic and molecular gas can occur. The
phenomenon is caused by stimulated emission of bosonic atoms or molecules into
their condensate phases
Dark soliton states of Bose-Einstein condensates in anisotropic traps
Dark soliton states of Bose-Einstein condensates in harmonic traps are
studied both analytically and computationally by the direct solution of the
Gross-Pitaevskii equation in three dimensions. The ground and self-consistent
excited states are found numerically by relaxation in imaginary time. The
energy of a stationary soliton in a harmonic trap is shown to be independent of
density and geometry for large numbers of atoms. Large amplitude field
modulation at a frequency resonant with the energy of a dark soliton is found
to give rise to a state with multiple vortices. The Bogoliubov excitation
spectrum of the soliton state contains complex frequencies, which disappear for
sufficiently small numbers of atoms or large transverse confinement. The
relationship between these complex modes and the snake instability is
investigated numerically by propagation in real time.Comment: 11 pages, 8 embedded figures (two in color
Executive function does not predict coping with symptoms in stable patients with a diagnosis of schizophrenia
<p>Abstract</p> <p>Background</p> <p>Associations between coping with and control over psychotic symptoms were examined using the Maastricht Assessment of Coping Strategies-24, testing the hypothesis that the cognitive domain of executive functioning predicted quality and quantity of coping.</p> <p>Methods</p> <p>MACS-24 was administered to 32 individuals with a diagnosis of schizophrenia. For each of 24 symptoms, experience of distress, type of coping and the resulting degree of perceived control were assessed. Coping types were reduced to two contrasting coping categories: symptomatic coping (SC) and non-symptomatic coping (NSC; combining active problem solving, passive illness behaviour, active problem avoiding, and passive problem avoiding). Cognitive functioning was assessed using the GIT (Groninger Intelligence Test), the Zoo map (BADS: Behavioural Assessment of Dysexecutive function), Stroop-test and Trail making.</p> <p>Results</p> <p>Cognitive function was not associated with frequency of coping, nor did cognitive function differentially predict SC or NSC. Cognitive function similarly was not associated with symptom distress or level of perceived control over the symptom.</p> <p>Conclusion</p> <p>There was no evidence that cognitive function predicts quantity or quality of coping with symptoms in people with a diagnosis of schizophrenia. Variation in the realm of emotion regulation and social cognition may be more predictive of coping with psychotic symptoms.</p
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