9 research outputs found
Positron emission mammography in breast cancer presurgical planning: comparisons with magnetic resonance imaging
Get PDFA platform approach to mechanically caged molecules
No full textInspired by interlocked oligonucleotides, peptides and knotted proteins, synthetic systems where a macrocycle cages a bioactive species that is “switched on” by breaking the mechanical bond have been reported. However, to date, each example uses a bespoke chemical design. Here we present a platform approach to mechanically caged structures wherein a single macrocycle precursor is diversified at a late stage to include a range of trigger units that control ring opening in response to enzymatic, chemical, or photochemical stimuli. We also demonstrate that our approach is applicable to other classes of macrocycles suitable for rotaxane and catenane formation
A Platform Approach to Cleavable Macrocycles for the Controlled Disassembly of Mechanically Caged Molecules
Get PDFInspired by interlocked oligonucleotides, peptides and knotted proteins, synthetic systems where a macrocycle cages a bioactive species that is “switched on” by breaking the mechanical bond have been reported. However, to date, each example uses a bespoke chemical design. Here we present a platform approach to mechanically caged structures wherein a single macrocycle precursor is diversified at a late stage to include a range of trigger units that control ring opening in response to enzymatic, chemical, or photochemical stimuli. We also demonstrate that our approach is applicable to other classes of macrocycles suitable for rotaxane and catenane formation
A platform approach to cleavable macrocycles for the controlled disassembly of mechanically caged molecules
No full textInspired by interlockedoligonucleotides,peptides and knotted proteins, synthetic systems where a macrocycle cages a bioactive species that is “switched on” by breaking the mechanical bond have been reported.However, to date, each example uses a bespoke chemical design. Here we present a platform approach to mechanically caged structures where in a single macrocycle precursor is diversified at a late stage to include a range of trigger units that control ring opening in response to enzymatic, chemical,or photo-chemical stimuli. We also demonstrate that our approach is applicable to other classes of macrocycles suitable for rotaxane and catenane formatio
Prenatal exposure to p,p′-DDE and p,p′-DDT in relation to lower respiratory tract infections in boys from a highly exposed area of Mexico
No full textPrenatal exposure to the major DDT metabolite 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and growth in boys from Mexico
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