A comparative survey of job prospects for the period 1991-1996

How discouraging is the job market for young scientists these days? It seems that most scientists who have tried to land a job in· recent years can tell you, unambiguously, Very. Are prospects bleaker for some experimental psychologists than for others? To us, it subjectively seemed so. In an effort to answer this question more rigorously. we analyzed issues of the APS Observer Employment Bulletin, published by the American Psychological Society, from 1991-1996. Admittedly, the number of classified ads for jobs in a specific category is only one index of the job prospects for that category, but it is a start

Looking for Stars and Finding the Moon: Effects of Lunar Gamma-ray Emission on Fermi LAT Light Curves

We are conducting a search for new gamma-ray binaries by making high signal-to-noise light curves of all cataloged Fermi LAT sources and searching for periodic variability using appropriately weighted power spectra. The light curves are created using a variant of aperture photometry where photons are weighted by the probability that they came from the source of interest. From this analysis we find that the light curves of a number of sources near the ecliptic plane are contaminated by gamma-ray emission from the Moon. This shows itself as modulation on the Moon's sidereal period in the power spectra. We demonstrate that this contamination can be removed by excluding times when the Moon was too close to a source. We advocate that this data screening should generally be used when analyzing LAT data from a source located close to the path of the Moon.Comment: 2012 Fermi Symposium proceedings - eConf C12102

Distance and intersection number in the curve graph of a surface

In this work, we study the cellular decomposition of $S$ induced by a filling pair of curves $v$ and $w$, $Dec_{v,w}(S) = S - (v \cup w)$, and its connection to the distance function $d(v,w)$ in the curve graph of a closed orientable surface $S$ of genus $g$. Efficient geodesics were introduced by the first author in joint work with Margalit and Menasco in 2016, giving an algorithm that begins with a pair of non-separating filling curves that determine vertices $(v,w)$ in the curve graph of a closed orientable surface $S$ and computing from them a finite set of {\it efficient} geodesics. We extend the tools of efficient geodesics to study the relationship between distance $d(v,w)$, intersection number $i(v,w)$, and $Dec_{v,w}(S)$. The main result is the development and analysis of particular configurations of rectangles in $Dec_{v,w}(S)$ called \textit{spirals}. We are able to show that, in some special cases, the efficient geodesic algorithm can be used to build an algorithm that reduces $i(v,w)$ while preserving $d(v,w)$. At the end of the paper, we note a connection of our work to the notion of extending geodesics.Comment: 20 pages, 17 figures. Changes: A key lemma (Lemma 5.6) was revised to be more precise, an irrelevant proposition (Proposition 2.1) and example were removed, unnecessary background material was taken out, some of the definitions and cited results were clarified (including added figures,) and Proposition 5.7 and Theorem 5.8 have been merged into a single theorem, Theorem 4.

Numerical renormalization-group study of the Bose-Fermi Kondo model

We extend the numerical renormalization-group method to Bose-Fermi Kondo models (BFKMs), describing a local moment coupled to a conduction band and a dissipative bosonic bath. We apply the method to the Ising-symmetry BFKM with a bosonic bath spectral function $\eta(\omega)\propto \omega^s$, of interest in connection with heavy-fermion criticality. For $0<s<1$, an interacting critical point, characterized by hyperscaling of exponents and $\omega/T$-scaling, describes a quantum phase transition between Kondo-screened and localized phases. Connection is made to other results for the BFKM and the spin-boson model.Comment: 4 pages, 4 figure

MANAGING DAIRY PROFIT RISK USING WEATHER DERIVATIVES

Replaced with revised version of paper 05/26/04.Risk and Uncertainty,

Merlin Phosphorylation by p21-activated Kinase 2 and Effects of Phosphorylation on Merlin Localization

The Nf2 tumor suppressor gene product merlin is related to the membrane-cytoskeleton linker proteins of the band 4.1 superfamily, including ezrin, radixin, and moesin (ERMs). Merlin is regulated by phosphorylation in a Rac/cdc42-dependent fashion. We report that the phosphorylation of merlin at serine 518 is induced by the p21-activated kinase PAK2. This is demonstrated by biochemical fractionation, use of active and dominant-negative mutants of PAK2, and immunodepletion. By using wild-type and mutated forms of merlin and phospho-directed antibodies, we show that phosphorylation of merlin at serine 518 leads to dramatic protein relocalization. Neurofibromatosis type 2 (NF2)1 is an inherited disorder characterized by the development of Schwann cell tumors of the eighth cranial nerve. Mutations and loss of heterozygosity of theNF2 gene have been detected in NF2 patients and in various sporadic tumors, including schwannomas, meningiomas, and ependymomas (1). In further support of a role for NF2 in tumor suppression, mice heterozygous for an Nf2 mutation are predisposed to a wide variety of tumors with high metastatic potential (2). In a separate model in which Nf2 is inactivated specifically in Schwann cells, mice develop schwannomas and Schwann cell hyperplasia (3). The longest and predominant splice form of the Nf2gene codes for a 595-amino acid protein highly similar to the band 4.1 family of proteins. It is most closely related to the ERM proteins,moesin, ezrin, and radixin. The ERM proteins are thought to function as cell membrane-cytoskeleton linkers and are localized to cortical actin structures near the plasma membrane such as microvilli, membrane ruffles, and lamellipodia (4, 5). Likewise, merlin is localized to cortical actin structures, in patterns that partially overlap with the ERMs (1). It has been proposed that intramolecular binding of the N-terminal and C-terminal domains conformationally regulates the ERM proteins by masking binding sites for interacting proteins. The ERMs can also form homodimers and heterodimers, among themselves and with merlin, adding an additional level of complexity to the regulation of these proteins (6). The recently solved crystal structure of the moesin N/C-terminal complex strengthens this model of conformational regulation (7). Given the sequence and, most likely, structural similarities of merlin to the ERM proteins, it is possible that merlin itself could be regulated in a similar fashion. Recent studies (8, 9) have implicated additional factors in the regulation of the ERMs, including phospholipids and phosphorylation. Previous work from our group and others (10, 11) has shown that merlin is differentially phosphorylated as well and that merlin protein levels are affected by growth conditions such as cell confluency, loss of adhesion, or serum deprivation. Merlin is found in an hypophosphorylated form when the combination of cellular and environmental conditions are growth-inhibitory (10). ERMs can be phosphorylated by Rho kinase, and this phosphorylation can affect intramolecular association and cellular localization. Phosphorylation and/or phospholipids may promote the transition of the proteins to an active form by “opening” intra- and intermolecular associations. These active monomers can then bind to other interacting proteins and the actin cytoskeleton and induce actin-rich membrane projections (5,8, 12, 13). The induction of merlin phosphorylation by activated alleles of the Rho family GTPases has also been examined. Interestingly, although activated Rho did not induce noticeable phosphorylation of merlin, activated forms of Rac and cdc42 did. The site of Rac-induced phosphorylation was determined to be a serine at position 518; mutation of serine 518 results in reduced basal phosphorylation and eliminated Rac-induced phosphorylation (11). Although Rac and cdc42 are implicated in the regulation of many pathways, they are most associated with regulation of cytoskeleton reorganization and gene expression (for recent reviews see Refs.14-16). In light of the data demonstrating that activated Rac/cdc42 leads to phosphorylation and possible inactivation of merlin, the elucidation of the responsible effector pathways and their effects on merlin function are of major importance. Understanding this regulation of merlin could lead to a more complete appreciation of the effects of merlin loss in tumors

Measuring Gaussian rigidity using curved substrates

The Gaussian (saddle splay) rigidity of fluid membranes controls their equilibrium topology but is notoriously difficult to measure. In lipid mixtures, typical of living cells, linear interfaces separate liquid ordered (LO) from liquid disordered (LD) bilayer phases at subcritical temperatures. Here we consider such membranes supported by curved supports that thereby control the membrane curvatures. We show how spectral analysis of the fluctuations of the LO-LD interface provides a novel way of measuring the difference in Gaussian rigidity between the two phases. We provide a number of conditions for such interface fluctuations to be both experimentally measurable and sufficiently sensitive to the value of the Gaussian rigidity, whilst remaining in the perturbative regime of our analysis.Comment: 5 pages, 3 figures. v2: version accepted for publicatio