4,149 research outputs found
Atlantic Ocean Heat Transport Enabled by Indo-Pacific Heat Uptake and Mixing
The ocean transports vast amounts of heat around the planet, helping to regulate regional climate. One important component of this heat transport is the movement of warm water from equatorial regions toward the poles, with colder water flowing in return. Here, we introduce a framework relating meridional heat transport to the diabatic processes of surface forcing and turbulent mixing that move heat across temperature classes. Applied to a (1/4)Ā° global ocean model the framework highlights the role of the tropical IndoāPacific in the global ocean heat transport. A large fraction of the northward heat transport in the Atlantic is ultimately sourced from heat uptake in the eastern tropical Pacific. Turbulent mixing moves heat from the warm, shallow IndoāPacific circulation to the cold deeperāreaching Atlantic circulation. Our results underscore a renewed focus on the tropical oceans and their role in global circulation pathways
A single Streptomyces symbiont makes multiple antifungals to support the fungus farming ant Acromyrmex octospinosus
Attine ants are dependent on a cultivated fungus for food and use antibiotics produced by symbiotic Actinobacteria as weedkillers in their fungus gardens. Actinobacterial species belonging to the genera Pseudonocardia, Streptomyces and Amycolatopsis have been isolated from attine ant nests and shown to confer protection against a range of microfungal weeds. In previous work on the higher attine Acromyrmex octospinosus we isolated a Streptomyces strain that produces candicidin, consistent with another report that attine ants use Streptomyces-produced candicidin in their fungiculture. Here we report the genome analysis of this Streptomyces strain and identify multiple antibiotic biosynthetic pathways. We demonstrate, using gene disruptions and mass spectrometry, that this single strain has the capacity to make candicidin and multiple antimycin compounds. Although antimycins have been known for > 60 years we report the sequence of the biosynthetic gene cluster for the first time. Crucially, disrupting the candicidin and antimycin gene clusters in the same strain had no effect on bioactivity against a co-evolved nest pathogen called Escovopsis that has been identified in similar to 30% of attine ant nests. Since the Streptomyces strain has strong bioactivity against Escovopsis we conclude that it must make additional antifungal(s) to inhibit Escovopsis. However, candicidin and antimycins likely offer protection against other microfungal weeds that infect the attine fungal gardens. Thus, we propose that the selection of this biosynthetically prolific strain from the natural environment provides A. octospinosus with broad spectrum activity against Escovopsis and other microfungal weeds.Publisher PDFPeer reviewe
Prehypertensive blood pressures and regional cerebral blood flow independently relate to cognitive performance in midlife
Background
High blood pressure is thought to contribute to dementia in late life, but our understanding of the relationship between individual differences in blood pressure (
BP
) and cognitive functioning is incomplete. In this study, cognitive performance in nonhypertensive midlife adults was examined as a function of resting
BP
and regional cerebral blood flow (
rCBF
) responses during cognitive testing. We hypothesized that
BP
would be negatively related to cognitive performance and that cognitive performance would also be related to
rCBF
responses within areas related to
BP
control. We explored whether deficits related to systolic
BP
might be explained by
rCBF
responses to mental challenge.
Methods and Results
Healthy midlife participants (n=227) received neuropsychological testing and performed cognitive tasks in a magnetic resonance imaging scanner. A pseudocontinuous arterial spin labeling sequence assessed
rCBF
in brain areas related to
BP
in prior studies. Systolic
BP
was negatively related to 4 of 5 neuropsychological factors (standardized Ī²>0.13): memory, working memory, executive function, and mental efficiency. The
rCBF
in 2 brain regions of interest was similarly related to memory, executive function, and working memory (standardized Ī²>0.17); however,
rCBF
responses did not explain the relationship between resting systolic
BP
and cognitive performance.
Conclusions
Relationships at midlife between prehypertensive levels of systolic
BP
and both cognitive and brain function were modest but suggested the possible value of midlife intervention.
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Quantifying inbreeding avoidance through extra-pair reproduction
Ā© 2014 The Author(s). Evolution Ā© 2014 The Society for the Study of Evolution.Peer reviewedPublisher PD
Changes in Health and Physical Fitness Parameters After 6 Months of High-intensity Group Exercise in Firefighters: Preliminary Data
The physical demands of firefighting require the men and women employed in this profession to be in optimal physical condition to perform their jobs proficiently, as well as to mitigate the risk of injury. Every year, the city of Addison, TX, budgets many thousands of dollars to the compensation plan for first responders. Most of the funding is used for rehabilitation services due to work related injuries. PURPOSE: While many of these injuries are unavoidable due to the inherent risks of the profession, ensuring proper physical fitness is one of the most effective methods to reduce many of these impairments. The purpose of this preliminary study was to characterize health and fitness parameters in 18 professional firefighters from the city of Addison, TX, prior to a 6-month training program. METHODS: Upon arrival, all participants underwent testing in the following order: body composition, range of motion, anaerobic power, muscular endurance, and cardiorespiratory fitness. All participants also completed a detailed health history questionnaire and answered questions specifically addressing chronic low back pain. RESULTS: The following values were attained from testing: total body fat: 30.1Ā±9.7%; flexibility: 24.9Ā±6.3 cm; peak power: 1068.7Ā±272.9 W; mean power: 636.9Ā±143.4 W; time to peak power 0.57Ā±0.35 sec; pushup: 28.8Ā±14.9; curl up: 22.1Ā±15.8; VO2max: 34.1Ā±5.1 ml/kg/min. CONCLUSION: Based off the comparison of reported means and ACSMās fitness norms, it can be concluded that improvements are necessary in body composition, muscular endurance, range of motion and cardiorespiratory fitness. With improvements in these physiological variables, tactical performance may be optimally performed in a safer manner
Mast Cell Regulation of the Immune Response
Mast cells are well known as principle effector cells of type I hypersensitivity responses. Beyond this role in allergic disease, these cells are now appreciated as playing an important role in many inflammatory conditions. This review summarizes the support for mast cell involvement in resisting bacterial infection, exacerbating autoimmunity and atherosclerosis, and promoting cancer progression. A commonality in these conditions is the ability of mast cells to elicit migration of many cell types, often through the production of inflammatory cytokines such as tumor necrosis factor. However, recent data also demonstrates that mast cells can suppress the immune response through interleukin-10 production. The data encourage those working in this field to expand their view of how mast cells contribute to immune homeostasis
Southern Ocean Overturning Compensation in an Eddy-Resolving Climate Simulation
The Southern Oceanās Antarctic Circumpolar Current (ACC) and meridional overturning circulation (MOC) response to increasing zonal wind stress is, for the first time, analyzed in a high-resolution (0.1Ā° ocean and 0.25Ā° atmosphere), fully coupled global climate simulation using the Community Earth System Model. Results from a 20-yr wind perturbation experiment, where the Southern Hemisphere zonal wind stress is increased by 50% south of 30Ā°S, show only marginal changes in the mean ACC transport through Drake Passageāan increase of 6% [136ā144 Sverdrups (Sv; 1 Sv ā” 10^6 m^3 s^(ā1))] in the perturbation experiment compared with the control. However, the upper and lower circulation cells of the MOC do change. The lower cell is more affected than the upper cell with a maximum increase of 64% versus 39%, respectively. Changes in the MOC are directly linked to changes in water mass transformation from shifting surface isopycnals and sea ice melt, giving rise to changes in surface buoyancy forcing. The increase in transport of the lower cell leads to upwelling of warm and salty Circumpolar Deep Water and subsequent melting of sea ice surrounding Antarctica. The MOC is commonly supposed to be the sum of two opposing components: a wind- and transient-eddy overturning cell. Here, the transient-eddy overturning is virtually unchanged and consistent with a large-scale cancellation of localized regions of both enhancement and suppression of eddy kinetic energy along the mean path of the ACC. However, decomposing the time-mean overturning into a time- and zonal-mean component and a standing-eddy component reveals partial compensation between wind-driven and standing-eddy components of the circulation
Atlantic Ocean Heat Transport Enabled by Indo-Pacific Heat Uptake and Mixing
The ocean transports vast amounts of heat around the planet, helping to regulate regional climate. One important component of this heat transport is the movement of warm water from equatorial regions toward the poles, with colder water flowing in return. Here, we introduce a framework relating meridional heat transport to the diabatic processes of surface forcing and turbulent mixing that move heat across temperature classes. Applied to a (1/4)Ā° global ocean model the framework highlights the role of the tropical IndoāPacific in the global ocean heat transport. A large fraction of the northward heat transport in the Atlantic is ultimately sourced from heat uptake in the eastern tropical Pacific. Turbulent mixing moves heat from the warm, shallow IndoāPacific circulation to the cold deeperāreaching Atlantic circulation. Our results underscore a renewed focus on the tropical oceans and their role in global circulation pathways
Probing the Emission States of PSR J1107ā5907
The emission from PSR J1107ā5907 is erratic. Sometimes the radio pulse is undetectable, at other times the pulsed emission is weak, and for short durations the emission can be very bright. In order to improve our understanding of these state changes, we have identified archival data sets from the Parkes radio telescope in which the bright emission is present, and find that the emission never switches from the bright state to the weak state, but instead always transitions to the "off" state. Previous work had suggested the identification of the "off" state as an extreme manifestation of the weak state. However, the connection between the "off" and bright emission reported here suggests that the emission can be interpreted as undergoing only two emission states: a "bursting" state consisting of both bright pulses and nulls, and the weak emission state
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