Estudio descriptivo sobre la influencia de la situación laboral de los padres en el ejercicio de la Parentalidad Positiva.

El concepto de Parentalidad Positiva implica el respeto de las necesidades de los niños y niñas que se expresa en el ejercicio de cuidados y atenciones adecuados, así como dinámicas relacionales y afectivas no violentas, basadas en el buen trato, el conocimiento del desarrollo evolutivo infantil, el diálogo y el respeto mutuo. Estudios recientes avalan que el cansancio emocional y físico que deriva de la carga laboral, hace que los padres sean menos propensos a mantener actitudes de diálogo y sensibilidad hacia las necesidades de los hijos, obstaculizando, de esta forma, el ejercicio de la Parentalidad Positiva. Por tanto, mediante un estudio observacional descriptivo transversal se ha estudiado la influencia de la situación laboral en el ejercicio de la Parentalidad Positiva, en un grupo de padres y madres cuyos niños frecuentan la clase experimental de 2 a 3 años del Colegio de Educación Infantil y Primaria “Antonio Mora Puchol” de Alicante, al fin de dar respuesta a la Hipótesis del autor, por la cual el hecho de que los progenitores trabajen, se relaciona con un menor ejercicio de la Parentalidad Positiva. Los resultados obtenidos indicaron que el 62.2% de los padres y las madres que se encontraban en situación de empleo, ejercían la Parentalidad Positiva por debajo de los que se consideran niveles óptimos. Dado que mediante esta tipología de estudio no es posible establecer relaciones causales entre las variables examinadas, se recomienda ampliar el campo de conocimiento hacia esta línea de investigación, para poner en relevo la exigencia de una reforma de las políticas de conciliación laboral, familiar y personal, que garanticen cuidados adecuados de los niños y niñas a favor de su correcto desarrollo

EDILIZIA BASSOMEDIEVALE IN VAL CAVALLINA E NEL SEBINO BERGAMASCO: STUDIO CRONOTIPOLOGICO DEGLI ELEMENTI ARCHITETTONICI E DEI PARAMENTI MURARI

Questo lavoro di ricerca ha come oggetto le architetture religiose, fortificate e civili di epoca bassomedievali conservate in Val Cavallina e sulla sponda occidentale del Sebino nella provincia orientale di Bergamo: questo territorio è privilegiato per la raccolta di dati utili alla definizione della seriazione cronotipologica degli elementi architettonici e dei paramenti murari datati tra XII e XV secolo. La redazione di tavole cronotipologiche è andata oltre l’aspetto tecnico, ma ha ricostruito i fenomeni sociali e politici di questo territorio in epoca bassomedievale: la costruzione dei castelli e delle torri condizionò la nuova rete insediativa dei borghi, definendo nuovi punti di aggregazione. Queste nuove costruzioni sono il riflesso di famiglie aristocrazie che utilizzano l’edilizia come strumento di affermazione di forza economica e potere sociale. L’analisi dei corpi di fabbrica condotto col metodo dell’archeologia dell’architettura ha consentito non solo la definizione delle tecniche edilizie, ma anche sulle dinamiche insediative nella provincia orientale di Bergamo. L’edilizia storica è fondamentale per comprendere i modi dell’abitare e di vivere: l’analisi di questi contesti ha consentito di distinguere specifiche tipologie abitative, e di ragionare sulle modalità occupazionali del territorio in epoca bassomedievale, riconoscendo per le due aree d’indagine peculiarità diverse.This research is related to late medieval age religious, fortified and civil architecture preserved in Val Cavallina and on the western side of Iseo Lake, in the eastern province of Bergamo: this territory is privileged for the collection of data useful for the definition of the chrono-typological seriation of architectural elements and walls, dating from the twelfth and fifteenth centuries. Chrono-typological tablets exceed technical aspects, and reconstruct the social and political appearance of this territory in the late medieval age: the construction of castles and towers conditioned the new settlement of villages, setting new aggregation points. These new buildings are a reflection of aristocracy’s families, who builds as statement of economic and social power strength. The insight of the buildings made with the archeological method allowed the definition of building techniques, and the settlement dynamics in the eastern province of Bergamo. The historic building is crucial to understand the ways to live: the analysis of medieval buildings has allowed distinguishing specific typology of houses and the occupational way to set the territory in the late medieval age; every area has his architectural peculiarities

‘A virtue beyond all medicine’ : The hanged man’s hand, gallows tradition and healing in eighteenth- and nineteenth-century England

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly citedFrom the eighteenth century through to the abolition of public executions in England in 1868, the touch of a freshly hanged man's hand was sought after to cure a variety of swellings, wens in particular. While the healing properties of corpse hands in general were acknowledged and experimented with in early modern medicine, the gallows cure achieved prominence during the second half of the eighteenth century. What was it about the hanged man's hand (and it always was a male appendage) that gave it such potency? While frequently denounced as a disgusting ‘superstition’ in the press, this popular medical practice was inadvertently legitimised and institutionalised by the authorities through changes in execution procedurePeer reviewe

hMENA11a contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells.

Human Mena (hMENA), an actin regulatory protein of the ENA/VASP family, cooperates with ErbB receptor family signaling in breast cancer. It is overexpressed in high-risk preneoplastic lesions and in primary breast tumors where it correlates with HER2 overexpression and an activated status of AKT and MAPK. The concomitant overexpression of hMENA and HER2 in breast cancer patients is indicative of a worse prognosis. hMENA is expressed along with alternatively expressed isoforms, hMENA11a and hMENAΔv6 with opposite functions. A novel role for the epithelial-associated hMENA11a isoform in sustaining HER3 activation and pro-survival pathways in HER2-overexpressing breast cancer cells has been identified by reverse phase protein array and validated in vivo in a series of breast cancer tissues. As HER3 activation is crucial in mechanisms of cell resistance to PI3K inhibitors, we explored whether hMENA11a is involved in these resistance mechanisms. The specific hMENA11a depletion switched off the HER3-related pathway activated by PI3K inhibitors and impaired the nuclear accumulation of HER3 transcription factor FOXO3a induced by PI3K inhibitors, whereas PI3K inhibitors activated hMENA11a phosphorylation and affected its localization. At the functional level, we found that hMENA11a sustains cell proliferation and survival in response to PI3K inhibitor treatment, whereas hMENA11a silencing increases molecules involved in cancer cell apoptosis. As shown in three-dimensional cultures, hMENA11a contributes to resistance to PI3K inhibition because its depletion drastically reduced cell viability upon treatment with PI3K inhibitor BEZ235. Altogether, these results indicate that hMENA11a in HER2-overexpressing breast cancer cells sustains HER3/AKT axis activation and contributes to HER3-mediated resistance mechanisms to PI3K inhibitors. Thus, hMENA11a expression can be proposed as a marker of HER3 activation and resistance to PI3K inhibition therapies, to select patients who may benefit from these combined targeted treatments. hMENA11a activity could represent a new target for antiproliferative therapies in breast cancer

Grupo Fasma v. The Eighth Judicial Dist. Ct. of the State of NV, 132 Nev. Adv. Op. 29 (Apr. 21, 2016)

Merely because service of process complies with the Hague Convention does not necessarily mean that it complies with constitutional Due Process. Here, the district court failed to conduct adequate fact-finding necessary to determine whether service of process complied with constitutional Due Process. Accordingly, the Court issued a writ of prohibition instructing the district court to vacate its order denying Grupo’s motion to quash so that an evidentiary hearing may be held on the matter

Southern Highlands v. San Florentine, 132 Nev. Adv. Op. 3 (Jan. 14, 2016)

Under the plain language of NRS 116.3116(4), “equal priority” is given to multiple HOA liens on the same property when those liens secure unpaid HOA charges and dues. When one lienholder of equal priority forecloses, all other liens are terminated. Nonetheless, all equal priority lienholders share in the foreclosure profit by either being paid in full when able to do so or, if sale profit is inadequate, through a pro-rata share of the proceeds. Thus, because the Foothills and Southern Highlands have equal priority liens, Foothills’ foreclosure terminated Southern Highlands lien, however Southern Highlands is entitled its allotment of the sale proceeds