16 research outputs found

    Integrated engineering environments for large complex products

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    An introduction is given to the Engineering Design Centre at the University of Newcastle upon Tyne, along with a brief explanation of the main focus towards large made-to-order products. Three key areas of research at the Centre, which have evolved as a result of collaboration with industrial partners from various sectors of industry, are identified as (1) decision support and optimisation, (2) design for lifecycle, and (3) design integration and co-ordination. A summary of the unique features of large made-to-order products is then presented, which includes the need for integration and co-ordination technologies. Thus, an overview of the existing integration and co-ordination technologies is presented followed by a brief explanation of research in these areas at the Engineering Design Centre. A more detailed description is then presented regarding the co-ordination aspect of research being conducted at the Engineering Design Centre, in collaboration with the CAD Centre at the University of Strathclyde. Concurrent Engineering is acknowledged as a strategy for improving the design process, however design coordination is viewed as a principal requirement for its successful implementation. That is, design co-ordination is proposed as being the key to a mechanism that is able to maximise and realise any potential opportunity of concurrency. Thus, an agentoriented approach to co-ordination is presented, which incorporates various types of agents responsible for managing their respective activities. The co-ordinated approach, which is implemented within the Design Co-ordination System, includes features such as resource management and monitoring, dynamic scheduling, activity direction, task enactment, and information management. An application of the Design Co-ordination System, in conjunction with a robust concept exploration tool, shows that the computational design analysis involved in evaluating many design concepts can be performed more efficiently through a co-ordinated approach

    New constraints on the Al 25 (p,Îł) reaction and its influence on the flux of cosmic Îł rays from classical nova explosions

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    The astrophysical Al25(p,γ)Si26 reaction represents one of the key remaining uncertainties in accurately modeling the abundance of radiogenic Al26 ejected from classical novae. Specifically, the strengths of key proton-unbound resonances in Si26, that govern the rate of the Al25(p,γ) reaction under explosive astrophysical conditions, remain unsettled. Here, we present a detailed spectroscopy study of the Si26 mirror nucleus Mg26. We have measured the lifetime of the 3+, 6.125-MeV state in Mg26 to be 19(3)fs and provide compelling evidence for the existence of a 1- state in the T=1,A=26 system, indicating a previously unaccounted for=1 resonance in the Al25(p,γ) reaction. Using the presently measured lifetime, together with the assumption that the likely 1- state corresponds to a resonance in the Al25+p system at 435.7(53) keV, we find considerable differences in the Al25(p,γ) reaction rate compared to previous works. Based on current nova models, we estimate that classical novae may be responsible for up to ≈15% of the observed galactic abundance of Al26

    Bio-analytical Assay Methods used in Therapeutic Drug Monitoring of Antiretroviral Drugs-A Review

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    Nitrate reductase and glutamine synthetase activity in coffee leaves during fruit development Atividade da redutase do nitrato e glutamina sintetase em folhas de cafeeiro durante o desenvolvimento dos frutos

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    Nitrate reductase is the first enzyme in the pathway of nitrate reduction by plants, followed by glutamine synthetase, which incorporates ammonia to glutamine. The purpose of this study was to evaluate the nitrate reductase and glutamine synthetase activity, total soluble protein content, N and Ni content in coffee leaves during fruit development under field conditions to establish new informations to help assess the N nutritional status and fertilizer management. The experimental design was in randomized complete blocks, arranged in a 3 x 6 factorial design, with five replications. The treatments consisted of 3 N rates (0 - control, 150 and 300 kg ha-1) and six evaluation periods (January, February, March, April, May, and June) in six-year-old coffee (Coffea arabica L.) plants of CatuaĂ­ Vermelho IAC 44 cv. The nitrate reductase and glutamine synthetase activities, leaf soluble protein, and N concentrations increased linearly with the N rates. During fruit development, the enzyme activity, leaf soluble protein and N content decreased, due to the leaf senescence process caused by nutrient mobilization to other organs, e.g, to the berries. Leaf Ni increased during fruit development. Beans and raisin-fruits of plants well-supplied with N had higher Ni contents. Enzyme activities, total leaf N and leaf soluble protein, evaluated during the green fruit stage in March, were significantly correlated with coffee yield. These variables can therefore be useful for an early assessment of the coffee N nutritional status as well as coffee yield and N fertilization management.<br>A redutase do nitrato (RN) Ă© a primeira enzima na via de redução de nitrato pelas plantas, seguida da glutamina sintetase (GS), a qual incorpora amĂŽnia Ă  glutamina. O objetivo deste trabalho foi avaliar a atividade dessas enzimas, o teor de proteĂ­na solĂșvel total e a concentração de N e de Ni em folhas e grĂŁos de cafeeiro durante o desenvolvimento dos frutos, em condiçÔes de campo, a fim de estabelecer novas informaçÔes para auxiliar a avaliação do estado nutricional do N e manejo da adubação. O experimento foi instalado em blocos ao acaso, em esquema fatorial 3 x 6, com trĂȘs doses de N (0, 150 e 300 kg ha-1) e seis Ă©pocas de avaliação (janeiro, fevereiro, março, abril, maio e junho), com cinco repetiçÔes. Foi utilizada a cultivar CatuaĂ­ Vermelho IAC 44 com seis anos de idade, no espaçamento de 1,75 m entre linhas e 0,75 m entre plantas. A atividade da RN e da GS e os teores de proteĂ­na solĂșvel e de N total aumentaram com as doses de N. Durante o crescimento dos frutos do cafeeiro, a atividade das enzimas e os teores foliares de proteĂ­na e de N diminuĂ­ram devido ao processo de senescĂȘncia das folhas e Ă  mobilização do N para a maturação dos grĂŁos. A concentração de Ni nas folhas e nos grĂŁos aumentou durante a fase de crescimento dos frutos. Plantas com estado nutricional adequado em N apresentaram maiores teores de Ni nos grĂŁos e nos frutos em estĂĄdio tipo passa. As atividades das enzimas eos teores foliares de N e de proteĂ­na solĂșvel total, durante o estĂĄdio de fruto verde, tĂȘm relação direta com a produção, constituindo-se em medidas auxiliares na avaliação do estado nutricional em N, na predição da produção do cafeeiro e no manejo da adubação nitrogenada
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