Building LGBT Nonprofit Leadership Talent: Thoughts and Suggestions for LGBT Organizations and Funders

Offers a model for supporting lesbian, gay, bisexual, and transgender nonprofit leadership development: define strategic aims and recruit, manage, develop, and retain talent. Includes practical guidance and list of LGBT leadership development programs

Carsey Perspectives: New Hampshire's Electricity Future

Over the past decade a number of factors have transformed global and national energy markets. Access to low-cost natural gas has been a significant part of this trend. Nationally, natural gas-fired power generation was expected to have exceeded coal-fired power generation for the first time in 2016,  and in New England about 50 percent of electricity is now generated from natural gas. With natural gas now such a large part of New England's energy mix, there is a concern that the demand for heating and electricity during cold periods will cause spikes in wholesale electricity prices and that demand may be greater than the available pipeline capacity to deliver natural gas. The region's utility industry has proposed the expansion of pipeline capacity to meet this seasonal increase in the demand for natural gas

Carsey Perspectives: New Hampshire\u27s Electricity Future; Cost, Reliability, and Risk

May 2017 update PointLogic Energy, a source for natural gas pipeline flow and capacity in the original report, has recently updated its models for calculating natural gas flow in the Tennessee Gas Pipeline in New England. This model update has resulted in significant changes to their previous estimates. Most importantly, data obtained from PointLogic Energy in December 2016 supported the finding that overall net gas flow in the “Tennessee Gas Pipeline: NY to MA” was from Massachusetts to New York from 2013–2016; their revised models indicate a net flow during the same period from New York to Massachusetts. To be conservative, we have removed analysis of natural gas pipeline flow and capacity from this report that relied on the original data obtained from PointLogic Energy. Instead, we use estimates of natural gas pipeline flow and capacity published in a 2014 ICF International report that was commissioned by ISO New England (Exhibit 2-3, pp. 12)a and information provided by the U.S. Energy Information Administration.b Please click here to read the previous version of this publication. In this perspectives brief, authors Cameron Wake, Matt Magnusson, Christine Foreman, and Fiona Wilson examine the cost of electrical power in New Hampshire and New England, the reliability of the electrical power system in terms of its ability to meet demand, and the risk New Hampshire ratepayers might face from various proposals to secure or increase the supply of electricity. They find evidence that near-term levels of demand and supply pose no threat to grid reliability, that current pipeline capacity is adequate, and that better contracting practices and other “soft-infrastructure” changes combined with the promotion of energy efficiency and renewable energy will have at least as large a return on investment as expanded pipeline capacity, without exposing ratepayers to higher electricity rates stemming from expensive infrastructure investments

Flight Operations for the LCROSS Lunar Impactor Mission

The LCROSS (Lunar CRater Observation and Sensing Satellite) mission was conceived as a low-cost means of determining the nature of hydrogen concentrated at the polar regions of the moon. Co-manifested for launch with LRO (Lunar Reconnaissance Orbiter), LCROSS guided its spent Centaur upper stage into the Cabeus crater as a kinetic impactor, and observed the impact flash and resulting debris plume for signs of water and other compounds from a Shepherding Spacecraft. Led by NASA Ames Research Center, LCROSS flight operations spanned 112 days, from June 18 through October 9, 2009. This paper summarizes the experiences from the LCROSS flight, highlights the challenges faced during the mission, and examines the reasons for its ultimate success

The Grizzly, April 29, 2010

Active Minds Hosts Art Fair to Benefit Mental Health • Students Say Farewell Through Presidential Celebration • UCDC Hosts Spring Concert in Lenfest Theater • Dr. Spencer Foreman: Counting Down the Reasons • Workout and Have Fun at Ursinus Zumba-Thon! • Music and Diplomacy Converge to Help Alleviate HIV and AIDS • Professor Mudd\u27s CIE III Class Explores Happiness and the UC Student Body • Class of 2010 Spotlight: Seniors Reflect on UC Memories • Ursinus College Mourns the Loss of a Legend • Senior Spotlight: Mark Worrilow, Footballhttps://digitalcommons.ursinus.edu/grizzlynews/1813/thumbnail.jp

Aptamer-based multiplexed proteomic technology for biomarker discovery

Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands of proteins from small sample volumes (15 [mu]L of serum or plasma). Our current assay allows us to measure ~800 proteins with very low limits of detection (1 pM average), 7 logs of overall dynamic range, and 5% average coefficient of variation. This technology is enabled by a new generation of aptamers that contain chemically modified nucleotides, which greatly expand the physicochemical diversity of the large randomized nucleic acid libraries from which the aptamers are selected. Proteins in complex matrices such as plasma are measured with a process that transforms a signature of protein concentrations into a corresponding DNA aptamer concentration signature, which is then quantified with a DNA microarray. In essence, our assay takes advantage of the dual nature of aptamers as both folded binding entities with defined shapes and unique sequences recognizable by specific hybridization probes. To demonstrate the utility of our proteomics biomarker discovery technology, we applied it to a clinical study of chronic kidney disease (CKD). We identified two well known CKD biomarkers as well as an additional 58 potential CKD biomarkers. These results demonstrate the potential utility of our technology to discover unique protein signatures characteristic of various disease states. More generally, we describe a versatile and powerful tool that allows large-scale comparison of proteome profiles among discrete populations. This unbiased and highly multiplexed search engine will enable the discovery of novel biomarkers in a manner that is unencumbered by our incomplete knowledge of biology, thereby helping to advance the next generation of evidence-based medicine

A Detection of Cosmological 21 cm Emission from CHIME in Cross-correlation with eBOSS Measurements of the Lyman-α\alpha Forest

We report the detection of 21 cm emission at an average redshift $\bar{z} = 2.3$ in the cross-correlation of data from the Canadian Hydrogen Intensity Mapping Experiment (CHIME) with measurements of the Lyman-$\alpha$ forest from eBOSS. Data collected by CHIME over 88 days in the $400-500$~MHz frequency band ($1.8 < z < 2.5$) are formed into maps of the sky and high-pass delay filtered to suppress the foreground power, corresponding to removing cosmological scales with $k_\parallel \lesssim 0.13\ \text{Mpc}^{-1}$ at the average redshift. Line-of-sight spectra to the eBOSS background quasar locations are extracted from the CHIME maps and combined with the Lyman-$\alpha$ forest flux transmission spectra to estimate the 21 cm-Lyman-$\alpha$ cross-correlation function. Fitting a simulation-derived template function to this measurement results in a $9\sigma$ detection significance. The coherent accumulation of the signal through cross-correlation is sufficient to enable a detection despite excess variance from foreground residuals $\sim6-10$ times brighter than the expected thermal noise level in the correlation function. These results are the highest-redshift measurement of \tcm emission to date, and set the stage for future 21 cm intensity mapping analyses at $z>1.8$

Common Sense Recommendations for the Application of Tax Law to Digital Assets

In response to the Joint Committee on Taxation’s July 2023 request for comments on application of various Internal Revenue Code sections on digital assets, we propose a consistent set of rules to apply current law to digital assets. We highlight that the underlying economics and characteristics of transactions should be the primary concern for the application of rules and the valuation of digital assets. We believe any digital asset rules should (1) treat classes of digital assets with unique characteristics differently based on their economics, (2) minimize incentives for users to engage in tax-motivated structuring of transactions, and (3) allow the Internal Revenue Service authority to react to and regulate new classes of digital assets as they are created. We do not believe that the unique features of digital assets are a challenge to applying current law or warrant special tax preferred treatment

Photometric redshifts for the next generation of deep radio continuum surveys - I: template fitting

We present a study of photometric redshift performance for galaxies and active galactic nuclei detected in deep radio continuum surveys. Using two multi-wavelength datasets, over the NOAO Deep Wide Field Survey Boötes and COSMOS fields, we assess photometric redshift (photo-z) performance for a sample of 4; 500 radio continuum sources with spectroscopic redshifts relative to those of 63; 000 non radio-detected sources in the same fields. We investigate the performance of three photometric redshift template sets as a function of redshift, radio luminosity and infrared/X-ray properties. We find that no single template library is able to provide the best performance across all subsets of the radio detected population, with variation in the optimum template set both between subsets and between fields. Through a hierarchical Bayesian combination of the photo-z estimates from all three template sets, we are able to produce a consensus photo-z estimate which equals or improves upon the performance of any individual template set