Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrence

Background: Atypical carcinoids (AC) of the lung are rare intermediate-grade neuroendocrine neoplasms. Prognostic factors for these tumours are undefined. Methods: Our cooperative group retrieved data on 127 patients operated between 1980 and 2009 because of an AC. Several clinical and pathological features were studied. Results: In a univariable analysis, T-status (p=0.005), N-status (p=0.021), preoperative M-status (previously treated) (p=0.04), and distant recurrence developed during the outcome (p<0.001) presented statistically significant differences related to survival of these patients. In a multivariable analysis, only distant recurrence was demonstrated to be an independent risk factor for survival (p<0.001; HR: 13.1). During the monitoring, 25.2% of the patients presented some kind of recurrence. When we studied recurrence factors in a univariable manner, sublobar resections presented significant relationship with locoregional recurrence (p<0.001). In the case of distant recurrence, T and N status presented significant differences. Patients with preoperative M1 status presented higher frequencies of locoregional and distant recurrence (p=0.004 and p<0.001, respectively). In a multivariable analysis, sublobar resection was an independent prognostic factor to predict locoregional recurrence (p=0.002; HR: 18.1). Conclusions: Complete standard surgical resection with radical lymphadenectomy is essential for AC. Sublobar resections are related to locoregional recurrence, so they should be avoided except for carefully selected patients. Nodal status is an important prognostic factor to predict survival and recurrence. Distant recurrence is related to poor outcome

Valoración del cambio de composición corporal en adolescentes con sobrepeso y obesidad incluidos en un tratamiento multidisciplinar: Estudio EVASYON

La adolescencia se considera una etapa vulnerable desde el punto de vista nutricional. La obesidad en la infancia y adolescencia se considera una enfermedad compleja, que preocupa tanto a padres como a profesionales sanitaros debido a su alta prevalencia y a sus consecuencias en la edad adulta. Por ello, los objetivos generales de este trabajo son: 1) valorar los índices antropométricos sencillos como predictores de los cambios de grasa corporal, empleando absorciometría dual de rayos X como método de referencia; 2) identificar los predictores cognitivos y conductuales del abandono de un estudio de intervención, y calcular la tasa de abandono; 3) valorar los cambios de composición corporal en niños y adolescentes, empleando diferentes métodos de composición corporal; y 4) valorar si el cumplimiento de la intervención dietética y el índice de calidad de la dieta son predictores de los cambios de composición corporal durante un seguimiento de 13 meses de una intervención multidisciplinar..

Designing a competency map for the degree of Pharmacy

El perfil propio de cada centro tanto desde el punto de vista académico, como profesional, viene marcado por la claridad de las competencias genéricas y especificas que han de alcanzar sus titulados. La dificultad de la gestión transversal del mapa de competencias de una titulación reside, entre otras, en la necesidad de que cada competencia se ha de servir desde una o más asignaturas y cada asignatura ha de servir a una o más competencias. El objetivo del presente trabajo consiste en sintetizar el proceso de definición e implementación de las competencias de la titulación del Grado en Farmacia, teniendo en cuenta que éstas se han de adecuar, permanentemente, a las demandas sociales, a los requisitos de calidad de la formación universitaria y a la mejora continua de sus procesos en el marco del Espacio Europeo de Educación Superior (EEES) y de la legislación vigente. Se especifican las capacidades, habilidades, valores y actitudes personales, a nivel de organización y técnicas a corto, medio y largo plazo, que facultan a los titulados para llevar a cabo las funciones propias de sus estudios y que los capacita para el pleno desarrollo de su ejercicio profesional

10 μ m-thick four-quadrant transmissive silicon photodiodes for beam position monitor application: electrical characterization and gamma irradiation effects

International audienceSilicon photodiodes are very useful devices as X-ray beam monitors in synchrotron radiation beamlines. Owing to Si absorption, devices thinner than 10 μ m are needed to achieve transmission over 90% for energies above 10 keV . In this work, new segmented four-quadrant diodes for beam alignment purposes are fabricated on both ultrathin (10 μ m-thick) and bulk silicon substrates. Four-quadrant diodes implementing different design parameters as well as auxiliary test structures (single diodes and MOS capacitors) are studied. An extensive electrical characterization, including current-voltage (I-V) and capacitance-voltage (C-V) techniques, is carried out on non-irradiated and gamma-irradiated devices up to 100 Mrad doses. Special attention is devoted to the study of radiation-induced charge build-up in diode interquadrant isolation dielectric, as well as its impact on device interquadrant resistance. Finally, the devices have been characterized with an 8 keV laboratory X-ray source at 10(8) ph/s and in BL13-XALOC ALBA Synchroton beamline with 10(11) ph/s and energies from 6 to 16 keV . Sensitivity, spatial resolution and uniformity of the devices have been evaluated

Four-quadrant silicon and silicon carbide photodiodes for beam position monitor applications: electrical characterization and electron irradiation effects

International audienceSilicon photodiodes are very useful devices as X-ray beam monitors in synchrotron radiation beamlines, as well as other astronomy and space applications. Owing to their lower susceptibility to variable temperature and illumination conditions, there is also special interest in silicon carbide devices for some of these applications. Moreover, radiation hardness of the involved technologies is a major concern for high-energy physics and space applications. This work presents four-quadrant photodiodes produced on ultrathin (10 μm) and bulk Si, as well as on SiC epilayer substrates. An extensive electrical characterization has been carried out by using current-voltage (I-V) and capacitance-voltage (C-V) techniques. The impact of different temperature (from −50oC to 175oC) and visible light conditions on the electrical characteristics of the devices has been evaluated. Radiation effects caused by 2 MeV electron irradiation up to 1×1014, 1×1015 and 1×1016 e/cm2 fluences have been studied. Special attention has been devoted to the study of charge build-up in diode interquadrant isolation, as well as its impact on interquadrant resistance. The study of these electrical properties and its radiation-induced degradation should be taken into account for device applications

Chimeric HLA antibody receptor T cells for targeted therapy of antibody-mediated rejection in transplantation

The presence of donor-specific antibodies (DSA), mainly against HLA, increases the risk of allograft rejection. Moreover, antibody-mediated rejection (ABMR) remains an important barrier to optimal long-term outcomes after solid organ transplantation. The development of chimeric autoantibody receptor T lymphocytes has been postulated for targeted therapy of autoimmune diseases. We aimed to develop a targeted therapy for DSA desensitization and ABMR, generating T cells with a chimeric HLA antibody receptor (CHAR) that specifically eliminates DSA-producing B cells. We have genetically engineered an HLA-A2-specific CHAR (A2-CHAR) and transduced it into human T cells. Then, we have performed in vitro experiments such as cytokine measurement, effector cell activation, and cytotoxicity against anti-HLA-A2 antibody-expressing target cells. In addition, we have performed A2-CHAR-Tc cytotoxic assays in an immunodeficient mouse model. A2-CHAR expressing T cells could selectively eliminate HLA-A2 antibody-producing B cells in vitro. The cytotoxic capacity of A2-CHAR expressing T cells mainly depended on Granzyme B release. In the NSG mouse model, A2-CHAR-T cells could identify and eradicate HLA-A2 antibody-producing B cells even when those cells are localized in the bone marrow. This ability is effector:target ratio dependent. CHAR technology generates potent and functional human cytotoxic T cells to target alloreactive HLA class I antibody-producing B cells. Thus, we consider that CHAR technology may be used as a selective desensitization protocol or an ABMR therapy in transplantation