Keeping Secrets from Ourselves: Understanding Self-deception Through Theory, Evidence and Application

Self-deception is a difficult concept to share with students. Although few students find it implausible that they are capable of keeping secrets from themselves, the social theory, application, and practical demonstration of self-deception is far from straightforward. This work offers a three-step approach to teach a theoretically-grounded, evidence-based, and application-reinforced understanding of self-deception. Rooted in work on identity by Mead (1934), the approach outlined here engages with interdisciplinary case studies derived from social psychology (Greenwald, McGhee and Schwartz 1998) and behavioral economics (Ariely 2012). The theory and case studies build toward a peer evaluation that offers students a concrete demonstration of self-deception with implications at the individual- and group-level

Irish Social Attitudes in 2018-19: topline results from round 9 of the European Social Survey

The National Coordinating Team at the Geary Institute for Public Policy at University College Dublin, in partnership with the Irish Research Council, is pleased to present the first national report ever produced for the European Social Survey in Ireland. Without peer, the European Social Survey has recorded the perspectives, aspirations, and concerns of the Irish population for nearly 20 years. Ireland has participated in each round of the biannual survey since the first (2002) and has already begun preparations for the 10th round, which will enter the field in 2021. This report offers an accessible and comprehensive overview of the main findings of the 9th round, which was collected by face-to-face interview between late 2018 and early 2019. The intention is to inform a broad audience and contextualise Irish public opinion over a period of significant economic uncertainty and demographic transformation.Irish Research Counci

Clinical impact of genomic testing in patients with suspected monogenic kidney disease

Purpose: To determine the diagnostic yield and clinical impact of exome sequencing (ES) in patients with suspected monogenic kidney disease. Methods: We performed clinically accredited singleton ES in a prospectively ascertained cohort of 204 patients assessed in multidisciplinary renal genetics clinics at four tertiary hospitals in Melbourne, Australia. Results: ES identified a molecular diagnosis in 80 (39%) patients, encompassing 35 distinct genetic disorders. Younger age at presentation was independently associated with an ES diagnosis (p < 0.001). Of those diagnosed, 31/80 (39%) had a change in their clinical diagnosis. ES diagnosis was considered to have contributed to management in 47/80 (59%), including negating the need for diagnostic renal biopsy in 10/80 (13%), changing surveillance in 35/80 (44%), and changing the treatment plan in 16/80 (20%). In cases with no change to management in the proband, the ES result had implications for the management of family members in 26/33 (79%). Cascade testing was subsequently offered to 40/80 families (50%). Conclusion: In this pragmatic pediatric and adult cohort with suspected monogenic kidney disease, ES had high diagnostic and clinical utility. Our findings, including predictors of positive diagnosis, can be used to guide clinical practice and health service design

The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma

We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) based on multidimensional and comprehensive characterization, including mitochondrial DNA (mtDNA) and whole genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared to other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting alternative roles for mtDNA mutations in cancers relying on oxidative phosphorylation. Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT up-regulation in cancer distinct from previously-observed amplifications and point mutations

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

Recent genomic analyses of pathologically-defined tumor types identify “within-a-tissue” disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head & neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multi-platform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All datasets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies

Immigration, identity, and anonymity: intentionally masked intolerance in Ireland

Newcomers to Ireland confront a context of reception shaped by large-scale historical emigration and more recent immigration defined by an increasingly diverse set of origin contexts, both within and outside the European Union (EU). How has the Irish population responded to these groups, and how openly do Irish residents express their views toward different immigrant groups? We test this response using a survey experiment, which offered respondents an anonymous way to express any negative attitudes to immigrant groups they may have had. Results from the survey experiment show that Irish residents’ support for Black and Polish immigrations is overstated when expressed directly. In contrast, their sentiment toward Muslim immigrants is notably insensitive to the level of anonymity provided, indicating little difference between overt and covert expression of support (or antipathy). In other words, when race/ethnicity or EU origin is made salient, Irish respondents are more likely to mask negative sentiment. When Islam is emphasized, however, Irish antipathy is not masked. We find that in-group preferences, instead of determining support in an absolute sense, shape the reluctance with which opposition to immigrant groups is overtly expressed

Austerity, short-term economic recovery and public perception of immigration in Ireland

The economic crisis of 2007/2008 did not affect all members of the European Union (EU) to the same extent. In the Irish case, the economic crisis and subsequent period of austerity paralleled an erosion in public support for immigration. However, little is known about how public perception changed during a period of short-term economic recovery, like that experienced in Ireland from 2014 to 2018. Using repeated cross-sectional survey data unique to Ireland, this work captures change in attitudes towards immigrants during the pre-crisis and late-austerity periods. Moreover, this research evaluates the importance placed on two immigrant attributes intimately linked to the labour market — education and skills. We provide evidence of an emergence of more moderate views of immigration during the recovery period, but only in the perceived importance of educational qualifications. Perception of skills remains notably unchanged. Of note, both attributes remain more important in the public eye relative to before the economic crisis. In other words, short-term economic recovery does not automatically translate into a more welcoming reception. We confirm that crises and periods of austerity erode public perception of newcomers, particularly when immigration is framed in terms of skill-based economic contribution. However, this work reveals some of the scars of a rapid and deep economic downturn alter the context of reception in a durable way, which remains notably resistant to short-term recovery

Educational mobility and attitudes towards migration from an international comparative perspective

Data de publicació electrònica: 8 d'agost de 2022This work considers the role of intergenerational educational mobility in shaping attitudes towards immigration. Two substantive questions drive this work. First, does the experience of stagnant or downward educational mobility result in negative attitudes towards immigration? Second, are perceptions of immigration shaped by the relative importance of parental (i.e. origin) and one’s own (i.e. destination) level of education? We deploy six waves of the European Social Survey (ESS) to assess how upward, downward and stagnant intergenerational educational mobility shape attitudes towards immigration across 31 countries. Results show that upward educational mobility can moderate antipathy towards immigration, but this is more applicable in country-contexts where parental education is less relevant. In other words, education matters for our understanding of how immigration is viewed, but its role must be framed in a way that takes into account multiple generations

Prospects for the comparative study of international migration using quasi-longitudinal micro-data

Background: Longitudinal micro-level data on international migration behavior is notoriously difficult to collect, but data collection efforts have become more frequent in recent years. However, comparative research on the patterns and processes of international migration remains quite rare, especially that which compares across regions. Objective: We highlight the promises and difficulties of comparative international migration research, by offering a detailed comparison of two prominent data collection efforts. Methods: We systematically review existing sources of longitudinal and quasi-longitudinal individual-level and household-level data on international migration. We then compare two widely used data sources: the Mexican Migration Project (MMP) and the Migration between Africa and Europe project (MAFE). Results: Data collection efforts are increasingly diverse, yet public accessibility to data remains limited. Also, comparability of data collected across settings can be complicated. In our MMP-MAFE analysis we show some ways in which comparability can be achieved. Conclusions: A primary roadblock to international comparative research is that, with some exceptions, the public accessibility of data remains low. Even when data is public and surveys are modeled after one another, comparability is not easy due to necessary trade-offs in adapting surveys to local settings and to developments in the field. Contribution: We demonstrate that, despite great strides in collecting quasi-longitudinal data on international migration, limited data accessibility still hinders the study of migration. With regards to comparability, our article provides important lessons for future data collection and analysis efforts that could improve comparability and thus advance understanding of the complex dynamics of international migration

Durational and generational differences in Mexican immigrant obesity: Is acculturation the explanation?

Using the Los Angeles Family and Neighborhood Survey (L.A.FANS-2; n = 1610), we explore the link between Mexican immigrant acculturation, diet, exercise and obesity. We distinguish Mexican immigrants and 2nd generation Mexicans from 3rd+ generation whites, blacks and Mexicans. First, we examine variation in social and linguistic measures by race/ethnicity, duration of residence and immigrant generation. Second, we consider the association between acculturation, diet and exercise. Third, we evaluate the degree to which acculturation, diet, exercise, and socioeconomic status explain the association between race/ethnicity, immigrant exposure to the US (duration since immigration/generation), and adult obesity. Among immigrants, we find a clear relationship between acculturation measures, exposure to the US, and obesity-related behaviors (diet and exercise). However, the acculturation measures do not clearly account for the link between adult obesity, immigrant duration and generation, and race/ethnicity