11,180 research outputs found
The induced path function, monotonicity and betweenness
The induced path function of a graph consists of the set of all vertices lying on the induced paths between vertices and . This function is a special instance of a transit function. The function satisfies betweenness if implies and implies , and it is monotone if implies . The induced path function of aconnected graph satisfying the betweenness and monotone axioms are characterized by transit axioms.betweenness;induced path;transit function;monotone;house domino;long cycle;p-graph
Design of a low-noise aeroacoustic wind tunnel facility at Brunel University
This paper represents the design principle of a quiet, low turbulence and moderately high speed aeroacoustic wind tunnel which was recently commissioned at Brunel University. A new hemi-anechoic chamber was purposely built to facilitate aeroacoustic measurements. The wind tunnel can achieve a maximum speed of about 80 ms-1. The turbulence intensity of the free jet in the potential core is between 0.1–0.2%. The noise characteristic of the aeroacoustic wind tunnel was validated by three case studies. All of which can demonstrate a very low background noise produced by the bare jet in comparison to the noise radiated from the cylinder rod/flat plate/airfoil in the air stream.The constructions of the aeroacoustic wind tunnel and the hemi-anechoic chamber are financially supported by the School of Engineering and Design at Brunel University
Structure and lattice dynamics of the wide band gap semiconductors MgSiN and MgGeN
We have determined the structural and lattice dynamical properties of the
orthorhombic, wide band gap semiconductors MgSiN and MgGeN using
density functional theory. In addition, we present structural properties and
Raman spectra of a MgSiN powder. The structural properties and lattice
dynamics of the orthorhombic systems are compared to wurtzite AlN. We find
clear differences in the lattice dynamics between MgSiN, MgGeN and
AlN, for example we find that the highest phonon frequency in MgSiN is
about 100~cm higher than the highest frequency in AlN and that
MgGeN is much softer. We also provide the Born effective charge tensors
and dielectric tensors of MgSiN, MgGeN and AlN. Phonon related
thermodynamic properties, such as the heat capacity and entropy, are in very
good agreement with available experimental results.Comment: 9 pages, 11 figures, 6 table
Annotating Synapses in Large EM Datasets
Reconstructing neuronal circuits at the level of synapses is a central
problem in neuroscience and becoming a focus of the emerging field of
connectomics. To date, electron microscopy (EM) is the most proven technique
for identifying and quantifying synaptic connections. As advances in EM make
acquiring larger datasets possible, subsequent manual synapse identification
({\em i.e.}, proofreading) for deciphering a connectome becomes a major time
bottleneck. Here we introduce a large-scale, high-throughput, and
semi-automated methodology to efficiently identify synapses. We successfully
applied our methodology to the Drosophila medulla optic lobe, annotating many
more synapses than previous connectome efforts. Our approaches are extensible
and will make the often complicated process of synapse identification
accessible to a wider-community of potential proofreaders
A blinded determination of from low-redshift Type Ia supernovae, calibrated by Cepheid variables
Presently a tension exists between values of the Hubble constant
derived from analysis of fluctuations in the Cosmic Microwave Background
by Planck, and local measurements of the expansion using calibrators of type Ia
supernovae (SNe Ia). We perform a blinded reanalysis of Riess et al. 2011 to
measure from low-redshift SNe Ia, calibrated by Cepheid variables and
geometric distances including to NGC 4258. This paper is a demonstration of
techniques to be applied to the Riess et at. 2016 data. Our end-to-end analysis
starts from available CfA3 and LOSS photometry, providing an independent
validation of Riess et al. 2011. We obscure the value of throughout our
analysis and the first stage of the referee process, because calibration of SNe
Ia requires a series of often subtle choices, and the potential for results to
be affected by human bias is significant. Our analysis departs from that of
Riess et al. 2011 by incorporating the covariance matrix method adopted in SNLS
and JLA to quantify SN Ia systematics, and by including a simultaneous fit of
all SN Ia and Cepheid data. We find (stat)
(sys) km s Mpc with a three-galaxy (NGC 4258+LMC+MW) anchor. The
relative uncertainties are 4.3% statistical, 1.1% systematic, and 4.4% total,
larger than in Riess et al. 2011 (3.3% total) and the Efstathiou 2014
reanalysis (3.4% total). Our error budget for is dominated by statistical
errors due to the small size of the supernova sample, whilst the systematic
contribution is dominated by variation in the Cepheid fits, and for the SNe Ia,
uncertainties in the host galaxy mass dependence and Malmquist bias.Comment: 38 pages, 13 figures, 13 tables; accepted for publication in MNRA
Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial.
More efficacious treatment regimens are needed for tuberculosis, however, drug development is impeded by a lack of reliable biomarkers of disease severity and of treatment effect. We conducted a directed screen of host biomarkers in participants enrolled in a tuberculosis clinical trial to address this need. Serum samples from 319 protocol-correct, culture-confirmed pulmonary tuberculosis patients treated under direct observation as part of an international, phase 2 trial were screened for 70 markers of infection, inflammation, and metabolism. Biomarker assays were specifically developed for this study and quantified using a novel, multiplexed electrochemiluminescence assay. We evaluated the association of biomarkers with baseline characteristics, as well as with detailed microbiologic data, using Bonferroni-adjusted, linear regression models. Across numerous analyses, seven proteins, SAA1, PCT, IL-1β, IL-6, CRP, PTX-3 and MMP-8, showed recurring strong associations with markers of baseline disease severity, smear grade and cavitation; were strongly modulated by tuberculosis treatment; and had responses that were greater for patients who culture-converted at 8weeks. With treatment, all proteins decreased, except for osteocalcin, MCP-1 and MCP-4, which significantly increased. Several previously reported putative tuberculosis-associated biomarkers (HOMX1, neopterin, and cathelicidin) were not significantly associated with treatment response. In conclusion, across a geographically diverse and large population of tuberculosis patients enrolled in a clinical trial, several previously reported putative biomarkers were not significantly associated with treatment response, however, seven proteins had recurring strong associations with baseline radiographic and microbiologic measures of disease severity, as well as with early treatment response, deserving additional study
Mathematics of random growing interfaces
We establish a thermodynamic limit and Gaussian fluctuations for the height
and surface width of the random interface formed by the deposition of particles
on surfaces. The results hold for the standard ballistic deposition model as
well as the surface relaxation model in the off-lattice setting. The results
are proved with the aid of general limit theorems for stabilizing functionals
of marked Poisson point processes.Comment: 12 page
Optical vortex generation from molecular chromophore arrays
The generation of light endowed with orbital angular momentum, frequently termed optical vortex light, is commonly achieved by passing a conventional beam through suitably constructed optical elements. This Letter shows that the necessary phase structure for vortex propagation can be directly produced through the creation of twisted light from the vacuum. The mechanism is based on optical emission from a family of chromophore nanoarrays that satisfy specific geometric and symmetry constraints. Each such array can support pairs of electronically delocalized doubly degenerate excitons whose azimuthal phase progression is responsible for the helical wave front of the emitted radiation. The exciton symmetry dictates the maximum magnitude of topological charge; detailed analysis secures the conditions necessary to deliver optical vortices of arbitrary order
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