New Strongly Coupled Sector at the Tevatron and the LHC

We examine the possibility that a new strong interaction is accessible to the Tevatron and the LHC. In an effective theory approach, we consider a scenario with a new color-octet interaction with strong couplings to the top quark, as well as the presence of a strongly coupled fourth-generation which could be responsible for electroweak symmetry breaking. We apply several constraints, including the ones from flavor physics. We study the phenomenology of the resulting parameter space at the Tevatron, focusing on the the forward-backward asymmetry in top pair production, as well as in the production of the fourth-generation quarks. We show that if the excess in the top production asymmetry is indeed the result of this new interaction, the Tevatron could see the first hints of the strongly coupled fourth-generation quarks. Finally, we show that the LHC with $\sqrt{s}=7~$TeV and $1~{\rm fb}^{-1}$ integrated luminosity should observe the production of fourth-generation quarks at a level at least one order of magnitude above the QCD prediction for the production of these states.Comment: 8 pages, 12 figure

N-Relaxion: Large Field Excursions from a Few Site Relaxion Model

Relaxion models are an interesting new avenue to explain the radiative stability of the Standard Model scalar sector. They require very large field excursions, which are difficult to generate in a consistent UV completion and to reconcile with the compact field space of the relaxion. We propose an N-site model which naturally generates the large decay constant needed to address these issues. Our model offers distinct advantages with respect to previous proposals: the construction involves non-abelian fields, allowing for controlled high energy behaviour and more model building possibilities, both in particle physics and inflationary models, and also admits a continuum limit when the number of sites is large, which may be interpreted as a warped extra dimension.Comment: 7 pages, 2 figures; v2: version to appear in PR

Is the LHC Observing the Pseudo-scalar State of a Two-Higgs Doublet Model ?

The ATLAS and CMS collaborations have recently shown data suggesting the presence of a Higgs boson in the vicinity of 125 GeV. We show that a two-Higgs doublet model spectrum, with the pseudo-scalar state being the lightest, could be responsible for the diphoton signal events. In this model, the other scalars are considerably heavier and are not excluded by the current LHC data. If this assumption is correct, future LHC data should show a strengthening of the $\gamma\gamma$ signal, while the signals in the $ZZ^{(*)}\to 4\ell$ and $WW^{(*)}\to 2\ell 2\nu$ channels should diminish and eventually disappear, due to the absence of diboson tree-level couplings of the CP-odd state. The heavier CP-even neutral scalars can now decay into channels involving the CP-odd light scalar which, together with their larger masses, allow them to avoid the existing bounds on Higgs searches. We suggest additional signals to confirm this scenario at the LHC, in the decay channels of the heavier scalars into $AA$ and $AZ$. Finally, this inverted two-Higgs doublet spectrum is characteristic in models where fermion condensation leads to electroweak symmetry breaking. We show that in these theories it is possible to obtain the observed diphoton signal at or somewhat above of the prediction for the standard model Higgs for the typical values of the parameters predicted.Comment: 6 pages, 5 figures, final version in Physical Review

Are the pentaquark sum rules reliable?

We rewiew and scrutinize the existing mass determinations of the pentaquarks from the exponential Laplace Sum Rules (LSR). We do not find any sum rule window for extracting optimal and reliable results from the LSR, due to the unusual slow convergence of the OPE and to the exceptional important role of the QCD continuum into the spectral function in this channel. Instead, we use in this channel,for the first time, Finite Energy Sum Rules (FESR), which exhibit a nice stability in the QCD continuum threshold t_c, at which one can extract, with a good accuracy, the mass of the lowest resonance. Including the D=7, 9 condensate contributions in the OPE, we obtain M_Theta=(1513+- 114) MeV, and the corresponding residue lambda_Theta^2= -(0.14-- 0.49)x 10^{-9} GeV^{12}, which favours the I=0, J=1/2, and negative parity S-wave interpretation of the Theta (1540). However, our analysis indicates a degeneracy between the unmixed I=0 and I=1 S-wave states. In the I=0, J=1/2, P-wave channel, we obtain, for the P-resonance, M_P = (1.99+- 0.19) GeV and lambda_P= -(0.7--7.1)x 10^{-9} GeV^{14}, which we expect to be discovered experimentally. Our results also suggest that some intuitive choices of the continuum threshold used in the LSR literature are inconsistent with the FESR results. Finally, a study of the Theta-K-N coupling using a vertex sum rule shows that, for the I=0, S-wave channel, the leading OPE contributions only start to order alpha_s^2 in the chiral limit m_s=0, indicating that the Theta is very narrow.Comment: Latex file 6 pages, 5 ps.figures. Contribution to the QCD 04 International Conference (Montpellier-5-9th July 2004) and to HEP-MAD 04 International Conference (Antananarivo 27th Sept-2nd Oct. 2004). To appear in Nucl. Phys. B (Proc. Suppl.) and in SLAC Econf. on-line Proceedings. Comments and References adde

Conditioning of hiPSC-derived cardiomyocytes using surface topography obtained with high throughput technology

Surface functionalization of polymers aims to introduce novel properties that favor bioactive responses. We have investigated the possibility of surface functionalization of polyethylene terephthalate (PET) sheets by the combination of laser ablation with hot embossing and the application of such techniques in the field of stem cell research. We investigated the response of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to topography in the low micrometer range. HiPSC-CMs are expected to offer new therapeutic tools for myocardial replacement or regeneration after an infarct or other causes of cardiac tissue loss. However, hiPSC-CMs are phenotypically immature compared to myocytes in the adult myocardium, hampering their clinical application. We aimed to develop and test a high-throughput technique for surface structuring that would improve hiPSC-CMs structural maturation. We used laser ablation with a ps-laser source in combination with nanoimprint lithography to fabricate large areas of homogeneous micron- to submicron line-like pattern with a spatial period of 3 µm on the PET surface. We evaluated cell morphology, alignment, sarcomeric myofibrils assembly, and calcium transients to evaluate phenotypic changes associated with culturing hiPSC-CMs on functionalized PET. Surface functionalization through hot embossing was able to generate, at low cost, low micrometer features on the PET surface that influenced the hiPSC-CMs phenotype, suggesting improved structural and functional maturation. This technique may be relevant for high-throughput technologies that require conditioning of hiPSC-CMs and may be useful for the production of these cells for drug screening and disease modeling applications with lower costs.Fil: Cortella, Lucas R. X.. Universidade de Sao Paulo; BrasilFil: Cestari, Idágene A.. Universidade de Sao Paulo; BrasilFil: Lahuerta, Ricardo D.. Universidade de Sao Paulo; BrasilFil: Arana, Matheus C.. Universidade de Sao Paulo; BrasilFil: Soldera, Marcos Maximiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas. Universidad Nacional del Comahue. Instituto de Investigación y Desarrollo en Ingeniería de Procesos, Biotecnología y Energías Alternativas; ArgentinaFil: Rank, Andreas. Technische Universität Dresden; AlemaniaFil: Lasagni, Andrés F.. Technische Universität Dresden; AlemaniaFil: Cestari, Ismar N.. Universidade de Sao Paulo; Brasi

Forest disturbance and growth processes are reflected in the geographical distribution of large canopy gaps across the Brazilian Amazon

Canopy gaps are openings in the forest canopy resulting from branch fall and tree mortality events. The geographical distribution of large canopy gaps may reflect underlying variation in mortality and growth processes. However, a lack of data at the appropriate scale has limited our ability to study this relationship until now. We detected canopy gaps using a unique LiDAR dataset consisting of 650 transects randomly distributed across 2500 km(2) of the Brazilian Amazon. We characterized the size distribution of canopy gaps using a power law and we explore the variation in the exponent, alpha. We evaluated how the alpha varies across the Amazon, in response to disturbance by humans and natural environmental processes that influence tree mortality rates. We observed that South-eastern forests contained a higher proportion of large gaps than North-western, which is consistent with recent work showing greater tree mortality rates in the Southeast than the Northwest. Regions characterized by strong wind gust speeds, frequent lightning and greater water shortage also had a high proportion of large gaps, indicating that geographical variation in alpha is a reflection of underlying disturbance processes. Forests on fertile soils were also found to contain a high proportion of large gaps, in part because trees grow tall on these sites and create large gaps when they fall; thus, canopy gap analysis picked up differences in growth as well as mortality processes. Finally, we found that human-modified forests had a higher proportion of large gaps than intact forests, as we would expect given that these forests have been disturbed. Synthesis. The proportion of large gaps in the forest canopy varied substantially over the Brazilian Amazon. We have shown that the trends can be explained by geographical variation in disturbance and growth. The frequency of extreme weather events is predicted to increase under climate change, and changes could lead to greater forest disturbance, which should be detectable as an increased proportion of large gaps in intact forests.Peer reviewe

Fractional dynamics and recurrence analysis in cancer model

In this work, we analyze the effects of fractional derivatives in the chaotic dynamics of a cancer model. We begin by studying the dynamics of a standard model, {\it i.e.}, with integer derivatives. We study the dynamical behavior by means of the bifurcation diagram, Lyapunov exponents, and recurrence quantification analysis (RQA), such as the recurrence rate (RR), the determinism (DET), and the recurrence time entropy (RTE). We find a high correlation coefficient between the Lyapunov exponents and RTE. Our simulations suggest that the tumor growth parameter ($\rho_1$) is associated with a chaotic regime. Our results suggest a high correlation between the largest Lyapunov exponents and RTE. After understanding the dynamics of the model in the standard formulation, we extend our results by considering fractional operators. We fix the parameters in the chaotic regime and investigate the effects of the fractional order. We demonstrate how fractional dynamics can be properly characterized using RQA measures, which offer the advantage of not requiring knowledge of the fractional Jacobian matrix. We find that the chaotic motion is suppressed as $\alpha$ decreases, and the system becomes periodic for $\alpha \lessapprox 0.9966$. We observe limit cycles for $\alpha \in (0.9966,0.899)$ and fixed points for $\alpha<0.899$. The fixed point is determined analytically for the considered parameters. Finally, we discover that these dynamics are separated by an exponential relationship between $\alpha$ and $\rho_1$. Also, the transition depends on a supper transient which obeys the same relationship

Development of technologies to support the diagnosis of infectious diseases and cancer to support the primary health care

54/2017). Publisher Copyright: © 2022, The Author(s).Purpose: Primary Health Care (PHC) is the coordinator of health care in Brazil and needs to be strengthened in the diagnostic field to increase health care quality. Aiming to improve the diagnostic tools currently available in PHC, this work describes the process of development and validation of two point-of-care biomedical devices for screening patients with syphilis or different kinds of cancer. Methods: The development of these devices followed nine stages of action based on the requirements established by the Ministry of Health. During development, both systems followed the stages of circuit planning, software simulation to verify the components used, cost assessment for the acquisition of features, simulation in contact matrix, development of the embedded system, and planning of the printed circuit board and storage box. Results: Both devices underwent preliminary functionality tests to assess their quality. The performance tests applied on the device to diagnose syphilis performed 8,733,194 requests, with a flow of 2426 requests/second, reaching the desired parameters of robustness, integrity, durability, and stability. In addition, functioning tests on the cancer-screening device indicated the ability to detect standard fluorescence in a minimal (150 uL) sample volume. Conclusions: Together, the methodology used for developing the devices resulted in promising equipment to improve the diagnosis and meet the requirements for executing technologies for testing and triaging patients in PHC.publishersversionpublishe