CO and CI maps of the starburst galaxy M82

The first map of an external galaxy in the 3P₁ - 3P0 fine-structure line of atomic carbon (CI) is presented towards the nucleus of the starbuster M82, and compared with the distinction of the CO J = 4 - 3 molecular emission. The CI traces features that are seen in lower transition CO maps, and shows that CI and the CO are well mixed and have similar spatial distributions. There are small differences between the CO J = 4 - 3 line and lower transition CO data towards the NE part of the molecular ring, where the emission is less prominent. The abundance ratio [CI]/[CO] across M82 is very high, with an average value ~ 0.5 across most of the nucleus, a factor at least 5 times that which is typical of dense molecular cloud cores seen in our own Galaxy. This means that on average, CI is overabundant towards M82. This result can be explained using models which provide enhancements to the CI abundance above normal Interstellar Medium values, a result of a greater cosmic ray flux in M82, or where there is substantial mixing of the gas

Protein folding rates correlate with heterogeneity of folding mechanism

By observing trends in the folding kinetics of experimental 2-state proteins at their transition midpoints, and by observing trends in the barrier heights of numerous simulations of coarse grained, C-alpha model, Go proteins, we show that folding rates correlate with the degree of heterogeneity in the formation of native contacts. Statistically significant correlations are observed between folding rates and measures of heterogeneity inherent in the native topology, as well as between rates and the variance in the distribution of either experimentally measured or simulated phi-values.Comment: 11 pages, 3 figures, 1 tabl

Understanding the Effects of Repetitive Transcranial Magnetic Stimulation on Neuronal Circuits

Despite the widespread use of repetitive transcranial magnetic stimulation (rTMS) in both research and clinical settings, there is a paucity of evidence regarding the effects of its application on neural activity. Studies investigating the effects of rTMS on human participants (Huang et al., 2005) have shown that patterned trains of rTMS can be used to modulate the sensitivity of motor pathways for a period outlasting the stimulation itself. These changes are often attributed to an rTMS-induced increase in neural plasticity or a change in excitability of the motor pathway. Evidence that rTMS can modify the strength of motor pathways has led to its introduction into stroke rehabilitation research. It is hypothesized that post-stroke, rTMS can enhance plasticity induction within the brain and, when combined with manual therapy, can facilitate surviving neurons assuming the function of those lost to the stroke (Hsu et al., 2012). In practice however, despite a multitude of studies investigating this approach, there remains no convincing evidence that rTMS is capable of promoting sustained long-term improvement in recovery, above the effects of rehabilitation alone (Hsu et al., 2012; Lefaucheur et al., 2014). We are of the opinion that a lack of advancement within the field is due to an incomplete understanding of the effects of TMS on neural elements. Here we discuss some of the existing evidence and propose experimental approaches that may enhance the human application of rTMS

Evidence for Asphericity in the Type IIn Supernova 1998S

We present optical spectropolarimetry obtained at the Keck-II 10-m telescope on 1998 March 7 UT along with total flux spectra spanning the first 494 days after discovery (1998 March 2 UT) of the peculiar type IIn supernova (SN) 1998S. The SN is found to exhibit a high degree of linear polarization, implying significant asphericity for its continuum-scattering environment. Prior to removal of the interstellar polarization, the polarization spectrum is characterized by a flat continuum (at p ~ 2%) with distinct changes in polarization associated with both the broad (FWZI >= 20,000 km/s) and narrow (unresolved, FWHM < 300 km/s) line emission seen in the total flux spectrum. When analyzed in terms of a polarized continuum with unpolarized broad-line recombination emission, an intrinsic continuum polarization of p ~ 3% results (the highest yet found for a SN), suggesting a global asphericity of >= 45% from the oblate, electron-scattering dominated models of Hoflich (1991). The smooth, blue continuum evident at early times is shown to be inconsistent with a reddened, single-temperature blackbody, instead having a color temperature that increases with decreasing wavelength. Broad emission-line profiles with distinct blue and red peaks are seen in the total flux spectra at later times, perhaps suggesting a disk-like or ring-like morphology for the dense (n_e ~ 10^7 cm^{-3}) circumstellar medium. Implications of the circumstellar scattering environment for the spectropolarimetry are discussed, as are the effects of uncertain removal of interstellar polarization.Comment: 25 pages + 2 tables + 14 figures, Submitted to The Astrophysical Journa

Chandra Observations of Type Ia Supernovae: Upper Limits to the X-ray Flux of SN 2002bo, SN 2002ic, SN 2005gj, and SN 2005ke

We set sensitive upper limits to the X-ray emission of four Type Ia supernovae (SNe Ia) using the Chandra X-ray Observatory. SN 2002bo, a normal, although reddened, nearby SN Ia, was observed 9.3 days after explosion. For an absorbed, high temperature bremsstrahlung model the flux limits are 3.2E-16 ergs/cm^2/s (0.5-2 keV band) and 4.1E-15 ergs/cm^2/s (2-10 keV band). Using conservative model assumptions and a 10 km/s wind speed, we derive a mass loss rate of \dot{M} ~ 2E-5 M_\odot/yr, which is comparable to limits set by the non-detection of Halpha lines from other SNe Ia. Two other objects, SN 2002ic and SN 2005gj, observed 260 and 80 days after explosion, respectively, are the only SNe Ia showing evidence for circumstellar interaction. The SN 2002ic X-ray flux upper limits are ~4 times below predictions of the interaction model currently favored to explain the bright optical emission. To resolve this discrepancy we invoke the mixing of cool dense ejecta fragments into the forward shock region, which produces increased X-ray absorption. A modest amount of mixing allows us to accommodate the Chandra upper limit. SN 2005gj is less well studied at this time. Assuming the same circumstellar environment as for SN 2002i, the X-ray flux upper limits for SN 2005gj are ~4 times below the predictions, suggesting that mixing of cool ejecta into the forward shock has also occurred here. Our reanalysis of Swift and Chandra data on SN 2005ke does not confirm a previously reported X-ray detection. The host galaxies NGC 3190 (SN 2002bo) and NGC 1371 (SN 2005ke) each harbor a low luminosity (L_X ~ 3-4E40 ergs/s) active nucleus in addition to wide-spread diffuse soft X-ray emission.Comment: 16 pages, to appear in ApJ (20 Nov 2007

The Supernova Gamma-Ray Burst Connection

The chief distinction between ordinary supernovae and long-soft gamma-ray bursts (GRBs) is the degree of differential rotation in the inner several solar masses when a massive star dies, and GRBs are rare mainly because of the difficulty achieving the necessary high rotation rate. Models that do provide the necessary angular momentum are discussed, with emphasis on a new single star model whose rapid rotation leads to complete mixing on the main sequence and avoids red giant formation. This channel of progenitor evolution also gives a broader range of masses than previous models, and allows the copious production of bursts outside of binaries and at high redshifts. However, even the production of a bare helium core rotating nearly at break up is not, by itself, a sufficient condition to make a gamma-ray burst. Wolf-Rayet mass loss must be low, and will be low in regions of low metallicity. This suggests that bursts at high redshift (low metallicity) will, on the average, be more energetic, have more time structure, and last longer than bursts nearby. Every burst consists of three components: a polar jet (~0.1 radian), high energy, subrelativistic mass ejection (~1 radian), and low velocity equatorial mass that can fall back after the initial explosion. The relative proportions of these three components can give a diverse assortment of supernovae and high energy transients whose properties may vary with redshift.Comment: 10 pages, to appear in AIP Conf. Proc. "Gamma Ray Bursts in the Swift Era", Eds. S. S. Holt, N. Gehrels, J. Nouse

PHotometry Assisted Spectral Extraction (PHASE) and identification of SNLS supernovae

Aim: We present new extraction and identification techniques for supernova (SN) spectra developed within the Supernova Legacy Survey (SNLS) collaboration. Method: The new spectral extraction method takes full advantage of photometric information from the Canada-France-Hawai telescope (CFHT) discovery and reference images by tracing the exact position of the supernova and the host signals on the spectrogram. When present, the host spatial profile is measured on deep multi-band reference images and is used to model the host contribution to the full (supernova + host) signal. The supernova is modelled as a Gaussian function of width equal to the seeing. A chi-square minimisation provides the flux of each component in each pixel of the 2D spectrogram. For a host-supernova separation greater than <~ 1 pixel, the two components are recovered separately and we do not use a spectral template in contrast to more standard analyses. This new procedure permits a clean extraction of the supernova separately from the host in about 70% of the 3rd year ESO/VLT spectra of the SNLS. A new supernova identification method is also proposed. It uses the SALT2 spectrophotometric template to combine the photometric and spectral data. A galaxy template is allowed for spectra for which a separate extraction of the supernova and the host was not possible. Result: These new techniques have been tested against more standard extraction and identification procedures. They permit a secure type and redshift determination in about 80% of cases. The present paper illustrates their performances on a few sample spectra.Comment: 27 pages, 18 Figures, 1 Table. Accepted for publication in A&