An open labeled clinical trail on the effect of Vrikshamla in Sthaulya (obesity) w.s.r to hyperlipidaemia

Obesity is one of the leading cause for more than 53 diseases and in India around 30 million peoples are suffering with Sthaulya (obesity), individual habits with stressful life, wrong dietary habits and sedentary life is the main cause of disease and no satisfactory treatment is available in conventional system. Hence there is need explore alternative system of Indian medicine like Ayurveda for the benefits of sufferers Ayurveda dealt this disease as Sthaulya (obesity) under Medoroga (Adipose tissue disorder) and many treatment modalities have been explained number of drugs in Brahatrayi (Charaka, Sushruta & Vagbhat) were cited Bhavamishra was the author of Bhavaprakash Nighantu (Lexicon) which is one of the Laghutrayis (Sharanghadara, Madhavanidhana & Bhavaprakash) text is highlighted with Karmaoushadi (action based drug) such as Amradi Phala Varga explained Vrikshamla considered as drug index of Ayurveda, thus present study was designed to screen the drug with properties of Kapha Medohara (ability to reduce Kapha & Fat), Medorogahara (reduces Adipose tissue), Sthaulyanashaka (Anti obesity) and Karshyakara (ability to make lean) from Bhavaprakasha Nighantu in Ayurveda

GESTURE BASED TOUCHPAD SECURITY SYSTEM WITH DESIGN OF TOUCH SCREEN CONTROLLER

The purpose of the project is to present a new approach on the design of security systems by using a touch sensitive device. Security is a permanent concern in a variety of environments ranging from physical access restriction in home and industrial settings to information security in digital systems. Numeric passwords, fingerprint recognition, and many other techniques have been extensively implemented in the past but they present certain drawbacks. The proposed technique makes use of a touch device to recognize symbols as passwords and takes time into account to add a new dimension and prevent password theft. We implemented a prototype that demonstrates the capabilities of the proposed security approach by showing one direct application in physical access restriction systems

Ayurvedic understanding and management of Trigeminal Neuralgia w.s.r. to Anantavaata - A Case Study

Trigeminal Neuralgia is one of the painful disorders involving fifth cranial nerve, causes severe unilateral pain over regions supplied by the branches of trigeminal nerve associated with tempero mandibular joint stiffness. Trigeminal neuralgia nearly can be correlated to Anantavaata, one of the 11 types of Shirorogas explained by Acharya Sushruta and is Vaatapradhaana Tridoshaja Vyadhi. Present study is conducted to know the efficacy of ayurvedic line of management in TN. A female patient of age 46 years, diagnosed with Trigeminal Neuralgia was treated with allopathy medications. But did not get satisfactory results. Hence patient approached our hospital and got Vaatahara and Brihmana line of management involving Nasya with Karpasasthyaadi Taila for 7 days, Shiropichu and Karnapoorana with Ksheerabala Taila, Gandoosha with Murchita Tila Taila and oral medications. Patient’s complaints were assessed before and after treatment with VAS pain scale and verbal descriptor scale for TMJ stiffness After Follow up patient had got relieved with the complaints and got satisfactory results with ayurvedic line of management

Pregnancy with pancytopenia: an observational study

Background: Pancytopenia is the reduction in all three major cellular elements of blood; hence it is the simultaneous presence of anaemia, leukopenia and thrombocytopenia. Pancytopenia is associated with many maternal and foetal complications during pregnancy like maternal sepsis, postpartum haemorrhage, pre-eclampsia and preterm labour, IUGR and intrauterine foetal demise.Methods: The study was conducted at BLDE (Deemed to be) University, Shri B. M. Patil Medical College Hospital and Research Centre. It’s an observational study done from November 2019-April 2020. The participants enrolled in the study were subjected for further clinical and laboratory evaluation and followed for feto-maternal outcome.Results: The incidence of pancytopenia with pregnancy in this study was 3% and all the patients were vegetarian by diet along with vitamin B12 and folic acid deficiency. They were associated with different maternal and foetal complications.Conclusions: Proper dietary counselling and well-balanced dietary plans even with plant originate food can prevent the micronutrients deficiency and avoid the deleterious consequences like pancytopenia

Development of a rapid screen for the endodermal differentiation potential of human pluripotent stem cell lines.

A challenge facing the human pluripotent stem cell (hPSC) field is the variability observed in differentiation potential of hPSCs. Variability can lead to time consuming and costly optimisation to yield the cell type of interest. This is especially relevant for the differentiation of hPSCs towards the endodermal lineages. Endodermal cells have the potential to yield promising new knowledge and therapies for diseases affecting multiple organ systems, including lung, thymus, intestine, pancreas and liver, as well as applications in regenerative medicine and toxicology. Providing a means to rapidly, cheaply and efficiently assess the differentiation potential of multiple hPSCs is of great interest. To this end, we have developed a rapid small molecule based screen to assess the endodermal potential (EP) of hPSCs, based solely on definitive endoderm (DE) morphology. This drastically reduces the cost and time to identify lines suitable for use in deriving endodermal lineages. We demonstrate the efficacy of this screen using 10 different hPSCs, including 4 human embryonic stem cell lines (hESCs) and 6 human induced pluripotent stem cell lines (hiPSCs). The screen clearly revealed lines amenable to endodermal differentiation, and only lines that passed our morphological assessment were capable of further differentiation to hepatocyte like cells (HLCs)

Simultaneous estimation of Etodolac and Paracetamol in bulk drug dosage form by RP-HPLC

A simple, specific, rapid, economical and accurate reverse phase high performance liquid chromatographic method was developed for simultaneous estimation of Etodolac and Paracetamol in bulk drug and tablet dosage form. Sepration was achieved by capcell pack C-18 column having 250 mm4.6 mm i.d. in isocratic mode, with mobile phase containing 25 nM potassium dihydrogen phosphate buffer(adjusted to pH 6.1 using ortho phosphoric acid) : methanol (40:60). The flow rate was 1.0 ml/min and effluents were monitored at 235 nm. The retention time of Etodolac and Paracetamol were 3.19 min and 6.08 min respectively. The linearity for Etodolac and Paracetamol were in the range of 10-100 ?g/ml. The recoveries of Etodolac and Paracetamol were found in the range of 99.27-99.78 % and 99.74-99.88 % respectively. The proposed method was validated as per ICH and USP guidelines and successfully applied to the estimation of Etodolac and Paracetamol in bulk drug and tablet dosage form

A study of hypertensive disorders of pregnancy and the fetal outcome in a tertiary care hospital: a prospective study

Background: Pregnancy induced hypertension is one of the major causes of feto maternal morbidity and mortality in pregnancy. The exact cause of PIH is unknown certain factors are known to increase the risk of PIH such as risk factor includes that young women with first pregnancy.Methods: The objective of this study was to assess the socio-demographic and clinico-pathological profile of the patients with hypertensive disorders of pregnancy and its associated fetal outcomes. A prospective study was conducted in department of obstetrics and gynecology Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura Karnataka from 15th July to 15th December 2018. All women admitted to labour ward with diagnosis of hypertensive disorders of pregnancy were included in the study after ruling out the exclusion criteria and thorough history, examination and laboratory evaluation were done and followed till delivery.Results: A total of 123 pregnant women with hypertensive disorder of pregnancy were enrolled in the study. Most of the participants were in the age group of 20 to 30 years. The PIH was seen mostly in primigravida, lower socioeconomic status and with lower educational levels. Emergency LSCS is the most common mode of delivery.Conclusions: The hypertensive disorder in pregnancy affects the majorly younger age group. It is most commonly seen in low socio-economic and uneducated population. Hence, there should be provided with proper antenatal care, early detection of hypertensive disorders for better feto-maternal outcome

Elimination of human rabies in Goa, India through an integrated One Health approach

Dog-mediated rabies kills tens of thousands of people each year in India, representing one third of the estimated global rabies burden. Whilst the World Health Organization (WHO), World Organization for Animal Health (OIE) and the Food and Agriculture Organization of the United Nations (FAO) have set a target for global dog-mediated human rabies elimination by 2030, examples of large-scale dog vaccination programs demonstrating elimination remain limited in Africa and Asia. We describe the development of a data-driven rabies elimination program from 2013 to 2019 in Goa State, India, culminating in human rabies elimination and a 92% reduction in monthly canine rabies cases. Smartphone technology enabled systematic spatial direction of remote teams to vaccinate over 95,000 dogs at 70% vaccination coverage, and rabies education teams to reach 150,000 children annually. An estimated 2249 disability-adjusted life years (DALYs) were averted over the program period at 526 USD per DALY, making the intervention ‘very cost-effective’ by WHO definitions. This One Health program demonstrates that human rabies elimination is achievable at the state level in India