A simple, specific, rapid, economical and accurate reverse phase high performance liquid chromatographic method was developed for simultaneous estimation of Etodolac and Paracetamol in bulk drug and tablet dosage form. Sepration was achieved by capcell pack C-18 column having 250 mm4.6 mm i.d. in isocratic mode, with mobile phase containing 25 nM potassium dihydrogen phosphate buffer(adjusted to pH 6.1 using ortho phosphoric acid) : methanol (40:60). The flow rate was 1.0 ml/min and effluents were monitored at 235 nm. The retention time of Etodolac and Paracetamol were 3.19 min and 6.08 min respectively. The linearity for Etodolac and Paracetamol were in the range of 10-100 ?g/ml. The recoveries of Etodolac and Paracetamol were found in the range of 99.27-99.78 % and 99.74-99.88 % respectively. The proposed method was validated as per ICH and USP guidelines and successfully applied to the estimation of Etodolac and Paracetamol in bulk drug and tablet dosage form
